Brain metastases from pancreatic adenocarcinoma

Zaanan, Aziz; Lequoy, Marie; Landi, Bruno; Lièvre, Astrid; Franco, Dominique; Taı̈eb, Julien

doi:10.1136/bcr.08.2008.0620

Cited by 9 publications

(3 citation statements)

References 16 publications

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“…[ 6 7 8 15 16 ] To the best of our knowledge, only 20 cases in which brain metastases from PC were identified ante-mortem have been reported until date, including the present case. [ 8 9 10 11 12 14 17 18 19 20 21 22 23 24 ] Table 1 summarizes the clinical features. Patients have been predominantly female (17 female, 3 male), and 17 (85%) have shown other remote metastases such as the liver, lungs, lymph nodes or bone.…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection of brain metastasis may play a very limited role and may allow long-term survival in patients for whom the primary PC is controlled or with particular oncocytic-type tumors such as IPMN-derived PC. [18] 58/male No Resection 2 weeks Palliative Liver Caricato et al [17] 67/male No Resection+chemo 12 months Curative None Marepaily et al [19] 36/female No Resection <1-month Curative Liver Matsumura et al [11] 64/male No Resection+radiation 10 months> Curative LN (mediastinal) Lemke et al [9] 48/female No Resection+radiation 10 years> Curative Liver 66/male No Resection+radiation 5 years Curative None Chiang et al [10] 54/male yes Resection+chemo+radiation <20 months Curative None Rajappa et al [21] 71/male No Resection+radiation 36 months Curative Liver Our case 68/male Yes Resection 3 months Palliative LN (para-aortic) BM without surgical resection Kuratsu et al [18] 56/male No Ommaya+radiation 9 months Curative LN (supraclavicular) Ohira et al [20] 25/male Yes None 42 days Palliative Bone Tsuji et al [23] 63/female No None <1 month Palliative Luna Park et al [12] 48 [8] 56/male No None 1 month Palliative Liver Kimura et al [14] 50/male No None 1 month Palliative Skin+liver Zaanan et al [24] 57/male No None 3 days Palliative Liver+lung Rao et al [22] 57/male Yes Radiation <3 months Palliative Liver+lung+bone BM -Brain metastasis; LN -Lymph node; PC -Pancreatic cancer…”

Section: Discussionmentioning

confidence: 99%

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Brain metastasis from pancreatic cancer: A case report and literature review

Matsumoto

Yoshida

2015

Asian J Neurosurg

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A 68-year-old man presented to our hospital with a 1-month history of slowly progressing altered mental status and gait disturbance. Magnetic resonance imaging and abdominal computed tomography revealed advanced pancreatic cancer (PC) with brain and para-aortic lymph node metastases. Gross total resection of the brain metastatic tumor was performed. Although symptoms improved, the patient died 3 months postoperatively. In general, the prognosis for PC patients with brain metastasis is very poor. Surgical resection of brain metastasis may play a very limited role in allowing long-term survival of patients for whom the primary PC is controlled or with particular oncocytic-type tumors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Brain metastasis from pancreatic cancer: A case report and literature review

Matsumoto

Yoshida

2015

Asian J Neurosurg

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“…In general the interactions near to a quantum critical point can be simply approximated as a universal four point interaction [7]. As in Fermi's theory of beta decay this will lead to 3-body decays with a universal spectrum.…”

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confidence: 99%

Signature for the absence of an event horizon

Barbieri¹,

Chapline²

2012

Physics Letters B

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A sharp dip in the spectrum of γ rays coming from compact objects below 70 MeV would be an unambiguous signal that compact astrophysical objects have a physical surface, and there is no event horizon. Observation of this effect would open a window for the empirical study of Planck scale physics IntroductionBlack hole solutions of the classical Einstein equations pose a number of conceptual difficulties, not the least of which is incompatibility with elementary quantum mechanics. It has been suggested that in reality the interior of a compact object is a "squeezed" version of the ordinary space-time vacuum [1]. This led to the suggestion [2,3] that the surface separating the squeezed vacuum from the ordinary vacuum is a physical surface that produces observable effects rather than an event horizon. One of us (GC) has coined the name "dark energy star" for a compact object where this surface is a quantum critical layer [4]. In sharp contrast with the celebrated prediction of classical general relativity that nothing happens to particles as they fall through the event horizon, one finds that in the quantum criticality picture ordinary matter will undergo a dramatic transformation at the surface of a dark energy star. In particular, elementary particles whose initial momentum exceeds a characteristic value Q 0 , on the order of 100(M o /M) 1/2 MeV/c, where M is the mass of the compact object, will be strongly scattered and can decay into other elementary particles [5]. These interactions are similar to those experienced by quasiparticles in a quantum liquid near to a quantum critical point. A remarkable prediction of this quantum criticality picture is that protons hitting the surface of a compact astrophysical object will decay into positrons and mesons [5].It happens that the quarks and gluons inside nucleons typically have momenta that exceed Q 0 for all known compact objects, and therefore will undergo strong interactions at the surface if the surface is a quantum critical layer. In grand unified models of elementary particles such as the Georgi-Glashow SU(5) model [6] nucleon disappearance will then proceed via the baryon number violating reactions:

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