Brain Metastases from Primary Lung Malignant Fibrous Histiocytoma: A Case Report

Kamath, S. V.; Tenreiro-Picon, O. R.; Ragland, Ronald L.; Smith, Thomas W.; Weaver, John P.; Knorr, John R.

doi:10.1111/jon199552133

Cited by 3 publications

(2 citation statements)

References 10 publications

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“…In order to find a better treatment and improve the survival rate, we performed next-generation DNA sequencing (NGS) of MFH tissue from a 61-year-old male with primary pulmonary MFH. In addition, we summarized the clinical features and prognosis of this rare pulmonary malignant tumor based on the published literature (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Primary pulmonary malignant fibrous histiocytoma: case report and literature review

Li¹,

Liu²,

Shi³

et al. 2017

J. Thorac. Dis.

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Malignant fibrous histiocytoma (MFH) is an aggressive soft tissue sarcoma known to occur in various organs. Primary MFH arising in the lung is quite rare. Herein we report a case of a 61-year-old male with primary pulmonary MFH and explore the underlying molecular mechanisms by next-generation sequencing (NGS). Five gene mutations in TSC2, ARID1B, CDK8, KDM5C and CASP8 were detected, and the mTOR inhibitor might be an effective treatment for this patient. In addition, we reviewed the scientific literature of approximately 23 primary pulmonary MFH case reports since 1990 and summarized the clinical features and prognosis of this rare pulmonary malignant tumor.

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Section: Introductionmentioning

confidence: 99%

Primary pulmonary malignant fibrous histiocytoma: case report and literature review

Li¹,

Liu²,

Shi³

et al. 2017

J. Thorac. Dis.

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“…[6] To the best of our knowledge, only seven cases of brain metastasis as a consequence of MFS have been reported, and this is the first case of metastasis from the chest wall. [3,4,[10][11][12]17,18] e study, number of patients, primary site, age, sex, and outcome of these studies are summarized in Table 1.…”

Section: Discussionmentioning

confidence: 99%

Brain metastasis from a thoracic myxofibrosarcoma: A case report and literature review

Neto

Bezerra²,

Silva

et al. 2022

Surgical Neurology International

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Background: Myxofibrosarcoma (MFS) is a type of sarcoma that mainly affects elderly people; it represents only 5% of all sarcomas and shows no line of differentiation. Intracranial MFS is a rare condition. At present, limited data exist regarding brain metastasis from MFS. This article reports a case of MFS and reviews the literature regarding MFS metastasis. Case Description: We report a case of brain metastasis from chest wall MFS. The patient was diagnosed with an anterior thoracic MFS and underwent surgery and radiotherapy. One year later, he noticed a tumor on his left shoulder, and more than 1 year thereafter, bilateral lung metastasis was observed. Twelve months after lung metastasis, he presented to the emergency department and underwent contrast-enhanced magnetic resonance imaging, which demonstrated a left frontal tumor suggestive of brain metastasis. Since the main hypothesis was a sarcoma metastasis at the location close to the left motor area, and the patient had a good Karnofsky performance scale, the patient underwent neuronavigation-guided surgery. After surgery, the patient developed Grade III hemiparesis and aphasia. Brain tumor histopathology confirmed a malignant neoplasm with osteosarcomatous differentiation and metastasis from MFS. Conclusion: We report a rare case of MFS metastasis. To the best of our knowledge, this is the eighth case of intracerebral metastasis from MFS.

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Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS)

Qorbani

Nelson

2019

Autops. Case Rep.

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Undifferentiated pleomorphic sarcoma (UPS) is a high-grade pleomorphic neoplasm with no identifiable line(s) of differentiation using currently available diagnostic techniques. Therefore, it is essentially a diagnosis of exclusion, which requires generous tissue sampling, adequate contextually interpreted immunohistochemistry, and relevant molecular studies. UPS is a common soft tissue sarcoma (historically one of the entities referred to as malignant fibrous histiocytoma (MFH)), which can develop in various organs, but lung involvement is usually due to metastasis. Primary Pulmonary UPS (PPUPS) is exceptionally rare and here we present a 66-year-old man who presented with anemia and weight loss, found to have a 17 cm right lung mass with invasion to the chest wall and diaphragm. Extensive sampling and immunohistochemistry studies failed to reveal any line of differentiation. Upon exclusion of a possible extrapulmonary origin, a diagnosis of PPUPS was rendered. In addition, we reviewed all 84 previously reported cases of PPUPS/PPMFH in the literature since 1979 and summarized the clinical information.

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Brain Metastases from Primary Lung Malignant Fibrous Histiocytoma: A Case Report

Abstract: Primary malignant fibrous histiocytomas are rare. The authors report on a 56-year-old man who presented with neurological symptoms due to cerebral metastasis of a primary malignant fibrous histiocytoma of the lung.

Cited by 3 publications

References 10 publications

Primary pulmonary malignant fibrous histiocytoma: case report and literature review

Primary pulmonary malignant fibrous histiocytoma: case report and literature review

Brain metastasis from a thoracic myxofibrosarcoma: A case report and literature review

Primary pulmonary undifferentiated pleomorphic sarcoma (PPUPS)

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