Brain microstructural abnormalities in type 2 diabetes mellitus: A systematic review of diffusion tensor imaging studies

Moghaddam, Hossein Sanjari; Sherbaf, Farzaneh Ghazi; Aarabi, Mohammad Hadi

doi:10.1016/j.yfrne.2019.100782

Cited by 55 publications

(69 citation statements)

References 148 publications

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“…It should also be noted that alterations in brain white matter have been observed among individuals with Type I and Type II diabetes (Moghaddam, Sherbaf, & Aarabi, 2019;Yoon et al, 2018). The present analyses included two individuals with diabetes.…”

Section: Limitations and Future Directionsmentioning

confidence: 97%

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Selvadurai

Corben

Delatycki

et al. 2020

Human Brain Mapping

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Friedreich ataxia is a progressive neurodegenerative disorder with reported abnormalities in cerebellar, brainstem, and cerebral white matter. White matter structure can be measured using in vivo neuroimaging indices sensitive to different white matter features. For the first time, we examined the relative sensitivity and relationship between multiple white matter indices in Friedreich ataxia to more richly characterize disease expression and infer possible mechanisms underlying the observed white matter abnormalities. Diffusion‐tensor, magnetization transfer, and T1‐weighted structural images were acquired from 31 individuals with Friedreich ataxia and 36 controls. Six white matter indices were extracted: fractional anisotropy, diffusivity (mean, axial, radial), magnetization transfer ratio (microstructure), and volume (macrostructure). For each index, whole‐brain voxel‐wise between‐group comparisons and correlations with disease severity, onset age, and gene triplet‐repeat length were undertaken. Correlations between pairs of indices were assessed in the Friedreich ataxia cohort. Spatial similarities in the voxel‐level pattern of between‐group differences across the indices were also assessed. Microstructural abnormalities were maximal in cerebellar and brainstem regions, but evident throughout the brain, while macroscopic abnormalities were restricted to the brainstem. Poorer microstructure and reduced macrostructural volume correlated with greater disease severity and earlier onset, particularly in peri‐dentate nuclei and brainstem regions. Microstructural and macrostructural abnormalities were largely independent. Reduced fractional anisotropy was most strongly associated with axial diffusivity in cerebral tracts, and magnetization transfer in cerebellar tracts. Multiple mechanisms likely underpin white matter abnormalities in Friedreich ataxia, with differential impacts in cerebellar and cerebral pathways.

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Section: Limitations and Future Directionsmentioning

confidence: 97%

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Selvadurai

Corben

Delatycki

et al. 2020

Human Brain Mapping

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show abstract

“…Diabetes is a well-known risk factor for cerebral infarction and is associated with increased risk of vascular dementia, with recent studies highlighting the adverse effects of diabetes on cognitive function via cerebral white matter lesions [44,45]. White matter hyperintensities are well detected in patients with diabetes [46]. The accumulation of damage in cerebral microvessels can lead to the progression of white matter hyperintensities by mechanisms shared with arteriosclerosis.…”

Section: Arteriosclerosis and Brain White Matter Lesionsmentioning

confidence: 99%

Nutrition Management in Older Adults with Diabetes: A Review on the Importance of Shifting Prevention Strategies from Metabolic Syndrome to Frailty

et al. 2020

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The increasing prevalence of older adults with diabetes has become a major social burden. Diabetes, frailty, and cognitive dysfunction are closely related to the mechanisms of aging. Insulin resistance, arteriosclerosis, chronic inflammation, oxidative stress, and mitochondrial dysfunction may be common mechanisms shared by frailty and cognitive impairment. Hyperglycemia, hypoglycemia, obesity, vascular factors, physical inactivity, and malnutrition are important risk factors for cognitive impairment and frailty in older adults with diabetes. The impact of nutrients on health outcomes varies with age; thus, shifting diet therapy strategies from the treatment of obesity/metabolic syndrome to frailty prevention may be necessary in patients with diabetes who are over 75 years of age, have frailty or sarcopenia, and experience malnutrition. For the prevention of frailty, optimal energy intake, sufficient protein and vitamin intake, and healthy dietary patterns should be recommended. The treatment of diabetes after middle age should include the awareness of proper glycemic control aimed at extending healthy life expectancy with proper nutrition, exercise, and social connectivity. Nutritional therapy in combination with exercise, optimal glycemic and metabolic control, and social participation/support for frailty prevention can extend healthy life expectancy and maintain quality of life in older adults with diabetes mellitus.

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“…On the other hand, correlation studies have shown interactions between the cerebellum and non-motor areas of the cerebral cortex (50). The inferior and middle temporal lobes contain fiber tracks (e.g., middle cerebellar peduncle and unciform fasciculus) crossing several brain regions and associating with language processing, verbal working memory, visual spatial perception (51), and so forth. The hippocampus is involved in different aspects of memory formation and learning process (10) and plays an important role during the cognitive process of normal cognition to Alzheimer's disease.…”

Section: Functional Connectivity Alteration In Type 2 Diabetes Mellitusmentioning

confidence: 99%

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

Liang

Tan

et al. 2020

Front. Neurol.

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Background: Type 2 diabetes mellitus (T2DM)-related cognitive decline is associated with neuroimaging changes. However, only a few studies have focused on early functional alteration in T2DM prior to mild cognitive impairment (MCI). This study aimed to investigate the early changes of global connectivity patterns in T2DM by using a resting-state functional magnetic resonance imaging (rs-fMRI) technique. Methods: Thirty-four T2DM subjects and 38 age-, sex-, and education-matched healthy controls (HCs) underwent rs-fMRI in a 3T MRI scanner. Degree centrality (DC) was used to identify the functional hubs of the whole brain in T2DM without MCI. Then the functional connectivity (FC) between hubs and the rest of the brain was assessed by using the hub-based approach. Results: Compared with HCs, T2DM subjects showed increased DC in the right cerebellum lobules III-V. Hub-based FC analysis found that the right cerebellum lobules III-V of T2DM subjects had increased FC with the right cerebellum crus II and lobule VI, the right temporal inferior/middle gyrus, and the right hippocampus. Conclusions: Increased DC in the right cerebellum regions III-V, as well as increased FC within cerebellar regions and ipsilateral cerebrocerebellar regions, may indicate an important pathophysiological mechanism for compensation in T2DM without MCI.

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Brain microstructural abnormalities in type 2 diabetes mellitus: A systematic review of diffusion tensor imaging studies

Cited by 55 publications

References 148 publications

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Multiple mechanisms underpin cerebral and cerebellar white matter deficits in Friedreich ataxia: The IMAGE‐FRDA study

Nutrition Management in Older Adults with Diabetes: A Review on the Importance of Shifting Prevention Strategies from Metabolic Syndrome to Frailty

Altered Functional Hubs and Connectivity in Type 2 Diabetes Mellitus Without Mild Cognitive Impairment

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