Brain-mimicking phantom for biomechanical validation of motion sensitive MR imaging techniques

Ozkaya, Efe; Triolo, Emily; Rezayaraghi, Fargol; Abderezaei, Javid; Meinhold, Waiman; Hong, Kyung Pyo; Alipour, Akbar; Kennedy, Paul; Fleysher, Lazar; Ueda, Jun; Balchandani, Priti; Eriten, Melih; Johnson, Curtis L.; Yang, Ya; Kurt, Mehmet

doi:10.1016/j.jmbbm.2021.104680

Cited by 12 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 Hydrophilic polymer networks swollen by water are an important class of soft materials in medicine, food industry, structural and robotics. [2][3][4][5][6][7][8][9] Multiphasic nature of hydrogels leads to considerable variations in mechanical properties and internal stresses with changing operating conditions such as temperature, humidity and osmolarity. 10 Proper characterization of evolution of material properties 11 and internal stresses due to constrained boundaries 12 are critical in reliability and safety of hydrogels in load-bearing applications as listed in ref.…”

Section: Introductionmentioning

confidence: 99%

Characterization of drying-induced changes in moduli and internal stresses in a constrained gel using laser vibrometry

Yerrapragada,

Yang,

Lee

et al. 2024

Soft Matter

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Characterization of drying-induced changes in moduli and internal stresses in a constrained gel using laser vibrometry

Yerrapragada,

Yang,

Lee

et al. 2024

Soft Matter

View full text Add to dashboard Cite

show abstract

“…The main reason for this difficulty is that the intrinsic motion of the brain is extremely small (in the order of 100 µm [20]), and therefore, very difficult to measure with conventional imaging tools. The most prominent method to track the brain motion is through magnetic resonance elastography (MRE) [21][22][23][24][25] in which an external actuator [26] is used to cause shear wave propagation into the brain tissue and then the resultant tissue displacement field is captured by using Phase-contrast MRI (PC-MRI) [22][23][24]27]. To capture the intrinsic brain motion without an external actuator however, previous medical imaging studies used cine PC-MRI [28], or displacement encoded imaging with stimulated echoes (DENSE) MRI [20,29,30].…”

Section: Introductionmentioning

confidence: 99%

Increased Hindbrain Motion in Chiari Malformation I Patients Measured Through 3D Amplified MRI (3D aMRI)

Abderezaei

Pionteck

Chuang

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Chiari Malformation type 1 (CM-I) is a neurological disorder characterized by morphological defects such as excessive cerebral tonsils herniation and vast associated symptomatology. Given that these structural defects cannot explain the underlying symptomatology, and might result in misdiagnosis, in this work, we studied the brains intrinsic motion to better understand the mechanisms of CM-I. We acquired 3D cine MRI of 14 healthy and 14 CM-I subjects and used 3D amplified MRI (3D aMRI) to visualize and measure the brains intrinsic motion during the cardiac cycle. We observed that the regional brain motion in CM-I was significantly higher than the healthy subjects, with anterior-posterior (AP) and superior-inferior (SI) displacements in cerebral tonsils and medulla having the highest differences between the healthy and CM-I (45% - 73% increased motion in the CM-I group). The motion of the cerebellum, and brainstem in AP directions (42% and 31% increased motion in the CM-I group, respectively), followed by the motion of the cerebral tonsils and medulla in medial-lateral (ML) directions were other significant differences found between the two groups (16% increased motion in the CM-I group). Additionally, for the CM-I subjects, we measured morphological parameters including the tonsil herniation, ratio of neural tissue in the foramen magnum, and 4th ventricle volume. We then used the morphometrics and brains intrinsic motion to analyze the symptomatology of the CM-I patients and their surgical outcomes. Interestingly, we found the ratio of neural tissue in the foramen to be directly correlated with the SI motion of the tonsils (r = 0.58). We also found the tonsil herniation to be directly correlated with the AP motion of the tonsils (r = 0.61), and AP and ML motions of the medulla (r = 0.66, and r = 0.57). Additionally, we found the ML motion of the tonsils to be the only indicator of the surgical outcome (AUC = 0.95), in which subjects with higher motion had an improved outcome. Although we did not observe a significant correlation between the brains motion and morphometrics on the CM-I symptoms due to our small sample size, illustrative cases increase our hope for the development of a future tool based on the brain biomechanics.

show abstract

Design, Construction, and Implementation of a Magnetic Resonance Elastography Actuator for Research Purposes

et al. 2022

View full text Add to dashboard Cite

Magnetic resonance elastography (MRE) is a technique for determining the mechanical response of soft materials using applied harmonic deformation of the material and a motion‐sensitive magnetic resonance imaging sequence. This technique can elucidate significant information about the health and development of human tissue such as liver and brain, and has been used on phantom models (e.g., agar, silicone) to determine their suitability for use as a mechanical surrogate for human tissues in experimental models. The applied harmonic deformation used in MRE is generated by an actuator, transmitted in bursts of a specified duration, and synchronized with the magnetic resonance signal excitation. These actuators are most often a pneumatic design (common for human tissues or phantoms) or a piezoelectric design (common for small animal tissues or phantoms). Here, we describe how to design and assemble both a pneumatic and a piezoelectric MRE actuator for research purposes. For each of these actuator types, we discuss displacement requirements, end‐effector options and challenges, electronics and electronic‐driving requirements and considerations, and full MRE implementation. We also discuss how to choose the actuator type, size, and power based on the intended material and use. © 2022 Wiley Periodicals LLC. Basic Protocol 1: Design, construction, and implementation of a convertible pneumatic MRE actuator for use with tissues and phantom models Basic Protocol 2: Design, construction, and implementation of a piezoelectric MRE actuator for localized excitation in phantom models

show abstract

Brain-mimicking phantom for biomechanical validation of motion sensitive MR imaging techniques

Cited by 12 publications

References 43 publications

Characterization of drying-induced changes in moduli and internal stresses in a constrained gel using laser vibrometry

Characterization of drying-induced changes in moduli and internal stresses in a constrained gel using laser vibrometry

Increased Hindbrain Motion in Chiari Malformation I Patients Measured Through 3D Amplified MRI (3D aMRI)

Design, Construction, and Implementation of a Magnetic Resonance Elastography Actuator for Research Purposes

Contact Info

Product

Resources

About