Brain MRI findings in a patient with scrub typhus infection

Scrub typhus manifesting with intracerebral hemorrhage: Case report and review of literature

“…We here present a case of scrub typhus (ST) manifesting with a large intracerebral hemorrhage, of which, to the best of our knowledge, only nine cases have been reported in the English language worldwide. [ 1 2 3 4 5 6 7 8 ] Most of these were secondary to deranged coagulation profile, disseminated intravascular coagulation (DIC) and/or hemophagocytic lymphohistiocytosis (HLH), which were absent in this case.…”

Clinical characteristics and effective treatments of scrub typhus-associated hemophagocytic lymphohistiocytosis in children

“…In our cases, kidney damage was found in two patients but the kidney function returned to normal within 3 days. Neyaz et al [30] reported brain MRI findings in a patient with scrub typhus. Central nervous system (CNS) clinical or imaging is often seen in HLH of patients [31].…”

Scrub Typhus Masquerading as Limbic Encephalitis

“…2-4 Although encephalitis is a quite common neurological manifestation of scrub typhus, neuroimaging characteristics are not well established. 4-7 White matter lesions, particularly involving the subcortical, periventricular deep white matter, corpus callosum, and cerebellar peduncles, as well as brainstem and basal ganglia, are the most frequently affected areas. 5-7 In some cases, micro-hemorrhages, as well as discrete, gray matter lesions, have been reported.…”

“…4-7 White matter lesions, particularly involving the subcortical, periventricular deep white matter, corpus callosum, and cerebellar peduncles, as well as brainstem and basal ganglia, are the most frequently affected areas. 5-7 In some cases, micro-hemorrhages, as well as discrete, gray matter lesions, have been reported. 5-7 Meningeal enhancement with gadolinium contrast is well recognized.…”