Brain MRI-guided focused ultrasound conceptualised as a tool for brain network intervention

Permezel, Fiona

doi:10.1016/j.jocn.2021.05.062

Cited by 3 publications

(5 citation statements)

References 152 publications

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“…On a different note, in our study, we assessed the effect on the brain FC of unilateral MRgFUS thalamotomy according to the commonly accepted pathogenic structure functional hypothesis of tremor, which is based on the cerebello-thalamo-cortical circuitries converging on the Vim. We conducted a hypothesis-driven ROI-to-ROI rs-fMRI analysis, exclusively focusing on tremor-related brain areas, to accomplish a “ single network” -based description ( 59 ) of medium-term effects (i.e., at 1 and 3 months postoperatively) of the MRgFUS treatment. Therefore, this is the first study to explore the rs-FC changes after the MRgFUS selective thalamotomy adopting a “ classic” ROI-based approach.…”

Section: Discussionmentioning

confidence: 99%

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Resting State Functional Connectivity Signatures of MRgFUS Vim Thalamotomy in Parkinson's Disease: A Preliminary Study

et al. 2022

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Magnetic Resonance-guided high-intensity Focused Ultrasound (MRgFUS) of the thalamic ventral intermediate nucleus (Vim) for tremor has increasingly gained interest as a new non-invasive alternative to standard neurosurgery. Resting state functional connectivity (rs-FC) correlates of MRgFUS have not been extensively investigated yet. A region of interest (ROI)-to-ROI rs-FC MRI “connectomic” analysis focusing on brain regions relevant for tremor was conducted on 15 tremor-dominant patients with Parkinson's disease who underwent MRgFUS. We tested whether rs-FC between tremor-related areas was modulated by MRgFUS at 1 and 3 months post-operatively, and whether such changes correlated with individual clinical outcomes assessed by the MDS-UPDRS-III sub items for tremor. Significant increase in FC was detected within bilateral primary motor (M1) cortices, as well as between bilateral M1 and crossed primary somatosensory cortices, and also between pallidum and the dentate nucleus of the untreated hemisphere. Correlation between disease duration and FC increase at 3 months was found between the putamen of both cerebral hemispheres and the Lobe VI of both cerebellar hemispheres, as well as between the Lobe VI of untreated cerebellar hemisphere with bilateral supplementary motor area (SMA). Drop-points value of MDS-UPDRS at 3 months correlated with post-treatment decrease in FC, between the anterior cingulate cortex and bilateral SMA, as well as between the Lobe VI of treated cerebellar hemisphere and the interpositus nucleus of untreated cerebellum. Tremor improvement at 3 months, expressed as percentage of intra-subject MDS-UPDRS changes, correlated with FC decrease between bilateral occipital fusiform gyrus and crossed Lobe VI and Vermis VI. Good responders (≥50% of baseline tremor improvement) showed reduced FC between bilateral SMA, between the interpositus nucleus of untreated cerebellum and the Lobe VI of treated cerebellum, as well as between the untreated SMA and the contralateral putamen. Good responders were characterized at baseline by crossed hypoconnectivity between bilateral putamen and M1, as well as between the putamen of the treated hemisphere and the contralateral SMA. We conclude that MRgFUS can effectively modulate brain FC within the tremor network. Such changes are associated with clinical outcome. The shifting mode of integration among the constituents of this network is, therefore, susceptible to external redirection despite the chronic nature of PD.

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Section: Discussionmentioning

confidence: 99%

“…Selective Vim lesion had remote effects, modifying the balance of FC between ROIs far from the site of the lesion. Therefore, we believe that the “whole” tremor-network should be considered as the ultimate target of MRgFUS thalamotomy in PD ( 59 ).…”

Section: Discussionmentioning

confidence: 99%

Resting State Functional Connectivity Signatures of MRgFUS Vim Thalamotomy in Parkinson's Disease: A Preliminary Study

et al. 2022

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“…There are three main types of the BBB penetrable nanoprobes that have been reported: active targeting, 38 passive targeting, 39 and physical means of focused ultrasound (FUS). 40 Here, the research progress of nanoprobes in diagnosis of orthotopic GBM is summarized, including inorganic nanoprobes, rare earth nanoprobes, and other nanoprobes.…”

Section: Imaging Of Gbm By Nanoprobesmentioning

confidence: 99%

“…With the advantages of prolonged circulation in vivo and easy modification to build theranostic nanoplatforms, nanoprobes are designed with the improved BBB penetrable for high‐performance GBM imaging. There are three main types of the BBB penetrable nanoprobes that have been reported: active targeting, 38 passive targeting, 39 and physical means of focused ultrasound (FUS) 40 . Here, the research progress of nanoprobes in diagnosis of orthotopic GBM is summarized, including inorganic nanoprobes, rare earth nanoprobes, and other nanoprobes.…”

Section: Image‐guided Diagnosis Of Gbmmentioning

confidence: 99%

Image‐guided diagnosis and treatment of glioblastoma

Bian

Wang

Chen

et al. 2023

VIEW

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Glioblastoma (GBM) is the most aggressive primary brain tumor with poor prognosis and high recurrence rate. The presence of the blood–brain barrier (BBB) prevents diagnostic and therapeutic drugs from penetrating and working in GBM. In traditional surgical treatment, it is difficult to completely distinguish the boundary between tumor and surrounding normal tissue, resulting in incomplete resection of tumor. Therefore, the diagnosis and treatment of GBM are very challenging. Several molecular probes and nanoprobes have been reported to successfully penetrate the BBB, selectively target and accumulate in GBM to achieve in situ imaging of brain tumors, thus achieving accurate diagnosis and treatment of orthotopic or non‐orthotopic GBM. This paper reviews the advances of molecular probes and nanoprobes in image‐guided diagnosis and treatment of GBM. The design principle, application, and advantages of each probe are enumerated in detail. Finally, the prospects and potential challenges of probes in the diagnosis and treatment of GBM are discussed with a view to further promote the study and application of novel imaging probes in GBM.

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“…Additionally, human MER is not possible in the research setting unless in the context of a therapeutic intervention, which therefore limits the studied population to diseased cohorts. A potential technology that may be able to provide further insights is brain-focused ultrasound, which has the ability to reversibly modulate the function of deep brain nuclei in a non-invasive procedure, with a neuromodulation focus as small as 2 mm [96]. Another potential method to interrogate sensory function of deep nuclei would be to test various sensory functions before and after DBS implantation [8].…”

Section: Difficulty Interrogating Deep Brain Nuclei For Sensory Funct...mentioning

confidence: 99%

Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review

Permezel,

Alty,

Harding

et al. 2023

Brain Sciences

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Parkinson’s Disease (PD) has historically been considered a disorder of motor dysfunction. However, a growing number of studies have demonstrated sensory abnormalities in PD across the modalities of proprioceptive, tactile, visual, auditory and temporal perception. A better understanding of these may inform future drug and neuromodulation therapy. We analysed these studies using a scoping review. In total, 101 studies comprising 2853 human participants (88 studies) and 125 animals (13 studies), published between 1982 and 2022, were included. These highlighted the importance of the basal ganglia in sensory perception across all modalities, with an additional role for the integration of multiple simultaneous sensation types. Numerous studies concluded that sensory abnormalities in PD result from increased noise in the basal ganglia and increased neuronal receptive field size. There is evidence that sensory changes in PD and impaired sensorimotor integration may contribute to motor abnormalities.

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Brain MRI-guided focused ultrasound conceptualised as a tool for brain network intervention

Cited by 3 publications

References 152 publications

Resting State Functional Connectivity Signatures of MRgFUS Vim Thalamotomy in Parkinson's Disease: A Preliminary Study

Resting State Functional Connectivity Signatures of MRgFUS Vim Thalamotomy in Parkinson's Disease: A Preliminary Study

Image‐guided diagnosis and treatment of glioblastoma

Brain Networks Involved in Sensory Perception in Parkinson’s Disease: A Scoping Review

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