Brain Natriuretic Peptide: A Predictor for Severity Respiratory Distress Syndrome in Newborns

Abstract

Background:Respiratory distress syndrome (RDS) is considered as one of the most popular prematurity-related respiratory problems and among the most prominent reasons of deaths in preterm infants. Objectives: Brain Natriuretic Peptide (BNP) is the secret of the volume and pressure overload response of the vessels and decreases due to resistance as well as rises in systemic vessels and also in decline of pulmonary artery pressure. In the present paper, BNP is considered as a biomarker for prediction of RDS scoring. Materials and Methods: In this case, 65 preterm infants under 37 weeks with an Apgar score more than seven and 65 healthy term infants were chosen. All of them were controlled for three days in NICU and then divided into 4 groups based on the RDS scoring and intensity, as well as chest x-ray findings; normal, mild, moderate, and severe. Serum BNP of all the infants was measured through ELISA kit and a questionnaire was filled up for each infant based on his/her demographic information and clinical findings. The collected data were analyzed by SPSS software based on the independent statistical t-test, one-sided variance analysis and X2. P < 0.05 was considered as the significant. Results:The study results revealed a significant difference between the two groups regarding the pregnancy age, weight and type of delivery between cases and control groups (P ≥ 0.05); but there was no significant difference between BNP in cases and control groups (P ≤ 0.05). However, the comparison between the mean of pregnancy weight, pregnancy age, and BNP based on RDS frequency among the patients was significant (P ≥ 0.05). Conclusions:The results of this study demonstrated that serum BNP level correlates with increased RDS scoring. Therefore, it is possible to use BNP as the prediction marker for the progressive changes of RDS which occur in premature infants.

Hemorheological profiles and chronic inflammation markers in transfusion-dependent and non-transfusion- dependent thalassemia

“…Our results agree with literature data on significantly lower serum leptin in patients when compared to controls (Karachaliou et al, 2006;Chaliasos et al, 2010;Shahramian et al, 2013;Elsayh et al, 2016). The low leptin in thalassaemia has been ascribed to the toxic effect of iron overload on adipose tissue (Chaliasoset al 2010).…”

N-terminal pro-brain natriuretic peptide as a biomarker for differentiating cardiac and pulmonary disease in term neonates with respiratory distress

“…Shahramian et al [ 10 ] conducted a case-control study involving 65 preterm infants aged <37 weeks with Apgar score >7 as cases and 65 term infants as controls and demonstrated that serum BNP level increased among RD cases.…”

Use of Brain Natriuretic Peptide in Predicting Severity of Respiratory Distress Syndrome in Neonates

“…Early identification of preterm neonates susceptible to RDS is important since they may benefit from prophylactic surfactant administration and/or less vigorous ventilation (3,4). In this regard, Shahramian et al (5) conducted a case control study involving 65 preterm infants < 37 weeks with Apgar score > 7 as cases and 65 term infants as controls and demonstrated that serum brain natriuretic peptide (BNP) levels correlated with increased severity of RDS among cases. They suggested that BNP can be used as a prediction marker for RDS in preterm neonates.…”

“…Therefore, levels measured soon after birth or in the cord blood may make interpretations difficult unless hour-or day-specific values of BNP and NT-pro-BNP are known. According to Shahramian et al study (5), cord blood BNP can be used to predict which preterm neonate is going to develop RDS. If it is so, neonates at risk of RDS could be monitored in a better way and receive early intervention, ultimately leading to improved survival.…”