Brain natriuretic peptide and all-cause mortality in patients with kidney failure and haemodialysis treatment

Abstract

Background: Brain natriuretic peptide (BNP) is a biomarker secreted from the heart in response to fluid overload. In patients with kidney failure, inadequate fluid management during haemodialysis may cause fluid overload and overhydration (OH), risk factors for mortality. The aim of this study was to analyse the relationships among BNP, OH and all-cause mortality in patients with kidney failure and haemodialysis. Methods: In this prospective observational study, five-year survival was analysed in 64 patients with kidney failure and haemodialysis. Univariate correlations were performed to analyse the relationships between BNP, OH, and all-cause mortality. Cox regression analysis was performed to adjust the relationship between BNP and all-cause mortality for selected baseline clinical and biochemical characteristics. Results: By the end of the study, 33 patients (52%) had died. Age (r=0.38), BNP level (r=0.48), handgrip strength (r=-0.34), lean tissue index (r=-0.41) and CRP level (r=-0.34, p=0.007) were significantly associated with all-cause mortality. BNP was found to be a significant predictor of all-cause mortality (HR 3.1). However, after adjusting for age, sex, handgrip strength, OH and CRP, BNP was no longer a statistically significant predictor of all-cause mortality. Instead, age, handgrip strength and CRP were significant predictors of all-cause mortality (HR 1.04; HR 0.94 and HR 2.41, respectively). Conclusions: In this study, BNP was correlated with all-cause mortality in patients with kidney failure and haemodialysis, but OH was not. When adjusting for other clinical and biochemical factors, age, inflammation, and handgrip strength were found to be independent and more important predictors of all-cause mortality than BNP.