Brain network construction and analysis for patients with mild cognitive impairment and Alzheimer's disease based on a highly‐available nodes approach

Abstract

Introduction: Using brain network and graph theory methods to analyze the Alzheimer's disease (AD) and mild cognitive impairment (MCI) abnormal brain function is more and more popular. Plenty of potential methods have been proposed, but the representative signal of each brain region in these methods remains poor performance. Methods: We propose a highly-available nodes approach for constructing brain network of patients with MCI and AD. With resting-state functional magnetic resonance imaging (rs-fMRI) data of 84 AD subjects, 81 MCI subjects, and 82 normal control (NC) subjects from the Alzheimer's Disease Neuroimaging Initiative Database, we construct connected weighted brain networks based on the different sparsity and minimum spanning tree. Support Vector Machine of Radial Basis Function kernel was selected as classifier. Results: Accuracies of 74.09% and 77.58% in classification of MCI and AD from NC, respectively. We also performed a hub node analysis and found 18 significant brain regions were identified as hub nodes. Conclusions: The findings of this study provide insights for helping understanding the progress of the AD. The proposed method highlights the effectively representative time series of brain regions of rs-fMRI data for construction and topology analysis brain network.

A 3D pseudo-continuous arterial spin labeling study of altered cerebral blood flow correlation networks in mild cognitive impairment and Alzheimer's disease

“…Compared with CN, altered BC was found in the inferior frontal gyrus in MCI, which was revealed in a prior study (Seo et al, 2013 ). The superior temporal gyrus was found to decrease significantly in BC in MCI and AD, which was also marked in a previous study (He et al, 2008 ; Zhang et al, 2021 ), which involved auditory (e.g., language) processing and social cognition (Bigler et al, 2007 ). Additionally, significant BC increased in the occipital gyrus (e.g., cuneus).…”