Brain Network Dysfunction in Bipolar Disorder

Adler, Caleb M.; DelBello, Melissa P.; Strakowski, Stephen M.

doi:10.1017/s1092852900020800

Cited by 92 publications

(75 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Noteworthy, data from the same resource indicate that expression levels of CACNA1C, ODZ4 and NCAN in these two areas are also significantly reduced in patients with BD and depression. BA10/46 map to neighbouring frontal and middle frontal regions in the prefrontal cortex and abnormalities in these brain areas have been described in both disorders 30,31 .…”

Section: Discussionmentioning

confidence: 99%

Genome-wide association study reveals two new risk loci for bipolar disorder

et al. 2014

View full text Add to dashboard Cite

Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide association studies (GWAS) have robustly identified the first common genetic variants involved in disease aetiology. The data also provide strong evidence for the presence of multiple additional risk loci, each contributing a relatively small effect to BD susceptibility. Large samples are necessary to detect these risk loci. Here we present results from the largest BD GWAS to date by investigating 2.3 million single-nucleotide polymorphisms (SNPs) in a sample of 24,025 patients and controls. We detect 56 genome-wide significant SNPs in five chromosomal regions including previously reported risk loci ANK3, ODZ4 and TRANK1, as well as the risk locus ADCY2 (5p15.31) and a region between MIR2113 and POU3F2 (6q16.1). ADCY2 is a key enzyme in cAMP signalling and our finding provides new insights into the biological mechanisms involved in the development of BD.

show abstract

Section: Discussionmentioning

confidence: 99%

Genome-wide association study reveals two new risk loci for bipolar disorder

et al. 2014

View full text Add to dashboard Cite

show abstract

“…15 These fully normalized images were resliced with trilinear interpolation to a final voxel size of 1.5 Â 1.5 Â 1.5 mm 3 . An additional modulation step was also included to ensure that the total amount of GM in each voxel was conserved before and after normalization.…”

Section: Image Processing and Analysismentioning

confidence: 99%

“…[1][2][3] However, these findings have not been consistently replicated. One possible explanation for this variability in neuroimaging findings is the complexity of the BD phenotype due to its polymorphic clinical manifestations and outcome.…”

Section: Introductionmentioning

confidence: 96%

Neural correlates of hallucinations in bipolar disorder

Neves

Duarte

Albuquerque

et al. 2016

Rev. Bras. Psiquiatr.

View full text Add to dashboard Cite

Objective: Approximately one-half of all patients affected by bipolar disorder present with psychotic features on at least one occasion. Several studies have found that alterations in the activity of mesolimbic and prefrontal regions are related to aberrant salience in psychotic patients. The aim of the present study was to investigate the structural correlates of a history of hallucinations in a sample of euthymic patients with bipolar I disorder (BD-I). Methods: The sample consisted of 21 euthymic patients with BD-I and no comorbid axis I DSM-IV-TR disorders. Voxel based morphometry (VBM) was used to compare patients with and without a lifetime history of hallucinations. Preprocessing was performed using the Diffeomorphic Anatomical Registration through Exponentiated Lie Algebra (DARTEL) algorithm for VBM in SPM8. Images were processed using optimized VBM. Results: The main finding of the present study was a reduction in gray matter volume in the right posterior insular cortex of patients with BD-I and a lifetime history of hallucinations, as compared to subjects with the same diagnosis but no history of hallucinations. Conclusions: This finding supports the presence of abnormalities in the salience network in BD patients with a lifetime history of hallucinations. These alterations may be associated with an aberrant assignment of salience to the elements of one's own experience, which could result in psychotic symptoms.

show abstract

“…Starkstein and colleagues (1987) suggested that the genetic predisposition for mood disorders and focal lesions in areas that are connected to the limbic system in the right hemisphere, or anterior subcortical atrophy, may provide the necessary factors for the developing of the symptoms. Similarly, in primary mania it has been suggested that the emotional disturbance may be a result of the lack of the inhibitory function of the frontal cortex on subcortical limbic structures, through mild abnormalities in these circuits (Adler et al 2006). Hyperintensities found in the subcortical white matter in some individuals with bipolar disorders may indicate diffuse lesions in circuits which are involved in mood regulation (Frey et al 2004).…”

Section: Neuropsychiatric Fi Ndingsmentioning

confidence: 99%

Psychiatric disorders and traumatic brain injury

Schwarzbold¹,

Diaz²,

Martins

et al. 2008

NDT

101

View full text Add to dashboard Cite

Psychiatric disorders after traumatic brain injury (TBI) are frequent. Researches in this area are important for the patients' care and they may provide hints for the comprehension of primary psychiatric disorders. Here we approach epidemiology, diagnosis, associated factors and treatment of the main psychiatric disorders after TBI. Finally, the present situation of the knowledge in this fi eld is discussed.

show abstract

Brain Network Dysfunction in Bipolar Disorder

Cited by 92 publications

References 64 publications

Genome-wide association study reveals two new risk loci for bipolar disorder

Genome-wide association study reveals two new risk loci for bipolar disorder

Neural correlates of hallucinations in bipolar disorder

Psychiatric disorders and traumatic brain injury

Contact Info

Product

Resources

About