Brain network dysregulation, emotion, and complaints after mild traumatic brain injury

Horn, Harm Jan van der; Liemburg, Edith J.; Scheenen, Myrthe; Koning, Myrthe E. de; Marsman, Jan-Bernard C; Spikman, Joke; Naalt, Joukje van der

doi:10.1002/hbm.23126

Cited by 46 publications

(48 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The dFC was found to be significantly correlated with the frequency of headache for the PPTH group and the intensity of pain for the migraine group. sFC and dFC may therefore be useful for exploring the pathophysiological mechanisms in PPTH and migraine [16]. Although it is hard to connect preclinical works and patients' experience, visual stimuli could accentuate the migraine pain following the physiological connection existing between the sensory pain processing region and the visual processing region.…”

Section: Sensory Differences Between Migraine and Ppthmentioning

confidence: 99%

Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons

Capi

Pomes

Andolina

et al. 2020

IJERPH

View full text Add to dashboard Cite

Background: Oftentimes, persistent post traumatic headache (PPTH) and migraine are phenotypically similar and the only clinical feature that differentiate them is the presence of a mild or moderate traumatic brain injury (mTBI). The aim of this study is to describe the differences in brain area and in biochemical cascade after concussion and to define the efficacy and safety of treatments in use. Methods: Sources were chosen in according to the International Classification of Headache Disorder (ICHD) criteria. Results: The articles demonstrated a significant difference between PPTH and migraine regarding static functional connectivity (sFC) and dynamic functional connectivity (dFC) in brain structure that could be used for exploring the pathophysiological mechanisms in PPTH. Many studies described a cascade of neuro-metabolic changes that occur after traumatic brain injury. These variations are associated to the mechanism occurring when developing a PPTH. Conclusions: The state of art of this important topic show how although the mechanisms underlying the development of the two different diseases are different, the treatment of common migraine is efficacious in patients that have developed a post traumatic form.

show abstract

Section: Sensory Differences Between Migraine and Ppthmentioning

confidence: 99%

Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons

Capi

Pomes

Andolina

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Mindfulness is a form of meditation, which is derived from Buddhism and involves focusing one's attention to the present moment, maintaining awareness and control of present thoughts, feelings and sensations, and observing them without judgment [70]. Interestingly, fMRI studies have shown that mindfulness increases activity of areas within the salience network [71], reduces default mode network activity [72], and alters the functional collaboration between the salience, executive, and default mode networks [65].…”

Section: Neural Network and Emotion Regulationmentioning

confidence: 99%

An integrated perspective linking physiological and psychological consequences of mild traumatic brain injury

et al. 2019

Self Cite

View full text Add to dashboard Cite

Despite the often seemingly innocuous nature of a mild traumatic brain injury (mTBI), its consequences can be devastating, comprising debilitating symptoms that interfere with daily functioning. Currently, it is still difficult to pinpoint the exact cause of adverse outcome after mTBI. In fact, extensive research suggests that the underlying etiology is multifactorial. In the acute and early sub-acute stages, the pathophysiology of mTBI is likely to be dominated by complex physiological alterations including cellular injury, inflammation, and the acute stress response, which could lead to neural network dysfunction. In this stage, patients often report symptoms such as fatigue, headache, unstable mood and poor concentration. When time passes, psychological processes, such as coping styles, personality and emotion regulation, become increasingly influential. Disadvantageous, maladaptive, psychological mechanisms likely result in chronic stress which facilitates the development of long-lasting symptoms, possibly via persistent neural network dysfunction. So far, a systemic understanding of the coupling between these physiological and psychological factors that in concert define outcome after mTBI is lacking. The purpose of this narrative review article is to address how psychophysiological interactions may lead to poor outcome after mTBI. In addition, a framework is presented that may serve as a template for future studies on this subject.

show abstract

“…Typically, these deficits are assessed individually per task (e.g., identified cognitive deficits); however, the influence of psychological response on physical or cognitive outcomes has received limited consideration. Neurobiological supporting evidence potentially linking psychological outcomes with chronic post-concussion alterations include both altered frontal-alpha symmetry on EEG assessment and dorsolateral prefrontal cortex connectivity, which have been associated with the neural substrates underlying psycho-affective health (Chen et al, 2008; Moore, Sauve, & Ellemberg, 2016; van der Horn et al, 2016). Interestingly, postural control testing of gait termination, a functional task with dorsolateral prefrontal cortex supraspinal control, has identified deficits post-concussion which provides further potential evidence linking the systems (Buckley, Munkasy, Tapia-Lovler, & Wikstrom, 2013; Oldham, Munkasy, Evans, Wikstrom, & Buckley, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…Physiologically, the hippocampus, amygdala, and prefrontal cortex brain regions are associated with depression and anxiety and neuroimaging investigations have identified physiological alterations in these regions following a concussion (Chen, Johnston, Petrides, & Ptito, 2008; McAllister et al, 2014; Reger et al, 2012; Sheline, Wang, Gado, Csernansky, & Vannier, 1996; van der Horn, Liemburg, Aleman, Spikman, & van der Naalt, 2016). There is also an association between lower functional connectivity in the bilateral frontal and salience network with elevated depression scores following concussion (van der Horn et al, 2016). Similarly, post-concussion metabolic alterations in the kynurenine pathway correlates with elevated anxiety levels (Singh et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Comparison of psychological response between concussion and musculoskeletal injury in collegiate athletes.

Turner

Langdon

Shaver

et al. 2017

Sport, Exercise, and Performance Psychology

View full text Add to dashboard Cite

The psychological response to musculoskeletal injuries has been well documented, however, research on the psychological response to concussion is limited. The Profile of Mood States (POMS) and the State-Trait Anxiety Inventory (STAI) have recently been used to assess the psychological recovery of concussions. Although some studies indicate that psychological response is different for musculoskeletal injuries and concussion, there is currently not enough information to indicate this difference occurs at specific clinical milestones. The purpose of this study was to compare the psychological responses of student-athletes who have been diagnosed with a concussion to those of athletes diagnosed with musculoskeletal injuries with similar recovery duration. Fifteen collegiate athletes who sustained a musculoskeletal injury were recruited and matched with 15 previously collected concussion participants. The main outcome measures were the scores of POMS constructs: tension-anxiety, anger-hostility, fatigue-inertia, depression-dejection, vigor-activity, confusion-bewilderment, and total mood disturbance and STAI (state anxiety only). Two-way MANOVAs was run to determine the effects of group and time on POMS and STAI constructs. There were no significant interactions identified, but follow-up ANOVAs identified a main effect for time for most POMS subscales, with POMS scores improving over time in both groups. Analyses also revealed that tension-anxiety, vigor-activity and the STAI were not affected by time or group. The findings of this study, that both groups’ psychological response to injury improves over time and at similar clinical milestones suggests reduction in sports and team related activities may play a substantial role in the psychological response to either concussion or musculoskeletal injury.

show abstract

Brain network dysregulation, emotion, and complaints after mild traumatic brain injury

Abstract: Functional interactions of the executive and salience networks were related to emotion regulation and complaints after mTBI, with a key role for the bilateral frontal network. These findings may have implications for future studies on the effect of psychological interventions.

Cited by 46 publications

References 63 publications

Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons

Persistent Post-Traumatic Headache and Migraine: Pre-Clinical Comparisons

An integrated perspective linking physiological and psychological consequences of mild traumatic brain injury

Comparison of psychological response between concussion and musculoskeletal injury in collegiate athletes.

Contact Info

Product

Resources

About