Brain neurodevelopmental markers related to the deficit subtype of schizophrenia

Takahashi, Tsutomu; Takayanagi, Yoichiro; Nishikawa, Yumiko; Nakamura, Mihoko; Komori, Yuko; Furuichi, Atsushi; Kido, Mikio; Sasabayashi, Daiki; Noguchi, Kyo; Suzuki, Michio

doi:10.1016/j.pscychresns.2017.05.007

Cited by 20 publications

(25 citation statements)

References 69 publications

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“…The size of these midline structures was reported to be associated with genotypic variation of potential susceptibility genes for schizophrenia, such as Disrupted‐in‐Schizophrenia‐1 ( DISC1 ) and brain‐derived neurotrophic factor ( BDNF ) . Gross brain abnormalities (i.e., smaller AI and altered OFC surface morphology) are especially evident in the deficit subtype of schizophrenia, which is characterized by a trait‐like feature of primary and prominent negative symptoms, supporting pervasive neurodevelopmental pathology in this specific subtype …”

Section: Mri Findings In Schizophreniamentioning

confidence: 98%

“…66,67 Gross brain abnormalities (i.e., smaller AI and altered OFC surface morphology) are especially evident in the deficit subtype of schizophrenia, which is characterized by a trait-like feature of primary and prominent negative symptoms, 68 supporting pervasive neurodevelopmental pathology in this specific subtype. 69 Given the notion of pre-onset gray matter reductions in psychotic disorders (as described later), subtle but widespread cortical findings in schizophrenia are also at least partly considered to be a consequence of early neurodevelopmental insult. Indeed, several studies have reported a direct relation between neurodevelopmental abnormalities in midline structures and volume reduction of the medial temporal regions specifically in schizophrenia.…”

Section: Mri Findings In Schizophreniamentioning

confidence: 99%

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Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

Takahashi

Suzuki

2018

Psychiatry Clin Neurosci

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To date, a large number of magnetic resonance imaging (MRI) studies have been conducted in schizophrenia, which generally demonstrate gray matter reduction, predominantly in the frontal and temporo-limbic regions, as well as gross brain abnormalities (e.g., a deviated sulcogyral pattern). Although the causes as well as timing and course of these findings remain elusive, these morphologic changes (especially gross brain abnormalities and medial temporal lobe atrophy) are likely present at illness onset, possibly reflecting early neurodevelopmental abnormalities. In addition, longitudinal MRI studies suggest that patients with schizophrenia and related psychoses also have progressive gray matter reduction during the transition period from prodrome to overt psychosis, as well as initial periods after psychosis onset, while such changes may become almost stable in the chronic stage. These active brain changes during the early phases seem to be relevant to the development of clinical symptoms in a region-specific manner (e.g., superior temporal gyrus atrophy and positive psychotic symptoms), but may be at least partly ameliorated by antipsychotic medication. Recently, increasing evidence from MRI findings in individuals at risk for developing psychosis has suggested that those who subsequently develop psychosis have baseline brain changes, which could be at least partly predictive of later transition into psychosis. In this article, we selectively review previous MRI findings during the course of psychosis and also refer to the possible clinical applicability of these neuroimaging research findings, especially in the diagnosis of schizophrenia and early intervention for psychosis.

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Section: Mri Findings In Schizophreniamentioning

confidence: 98%

Section: Mri Findings In Schizophreniamentioning

confidence: 99%

Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

Takahashi

Suzuki

2018

Psychiatry Clin Neurosci

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“…While research into the neurobiology of negative symptoms continues (Takahashi et al, 2017), it remains unclear whether negative symptoms are best understood themselves as primary facts unto themselves, suggested by constructs such as the deficit syndrome (Ahmed, Strauss, Buchanan, Kirkpatrick, & Carpenter, 2018) or as experience which is a response to the kinds of fragmentation originally described by Bleuler. This issue has far-reaching clinical significance.…”

Section: Introductionmentioning

confidence: 99%

Metacognitive capacity and negative symptoms in first episode psychosis: Evidence of a prospective relationship over a 3-year follow-up

Austin

Lysaker

Jansen

et al. 2019

Journal of Experimental Psychopathology

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Negative symptoms can be linked to Bleuler's concept of splitting or fragmentation of thought, affect, and will. Research has shown a link between disturbances in metacognition and negative symptoms, although relatively few studies have examined this relationship longitudinally. The aim of this article is to examine whether metacognitive capacity among patients with first episode psychosis (FEP) predicted negative symptoms after a follow-up period of 3 years. Metacognition was assessed using the Metacognition Assessment Scale abbreviated and symptoms were assessed using Positive and Negative Syndrome Scale among 59 adults with FEP. Symptoms were then reassessed at a 3-year follow-up. Significant correlations were found

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“…A total of 24 studies were included in the systematic review process, eight of which were recruited for meta-analysis [ 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies

Chee

Chua

Morrin

et al. 2020

IJERPH

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Little is known regarding the neuroanatomical correlates of patients with deficit schizophrenia or persistent negative symptoms. In this meta-analysis, we aimed to determine whether patients with deficit schizophrenia have characteristic brain abnormalities. We searched PubMed, CINAHL and Ovid to identify studies that examined the various regions of interest amongst patients with deficit schizophrenia, patients with non-deficit schizophrenia and healthy controls. A total of 24 studies met our inclusion criteria. A random-effects model was used to calculate a combination of outcome measures, and heterogeneity was assessed by the I2 statistic and Cochran’s Q statistic. Our findings suggested that there was statistically significant reduction in grey matter volume (−0.433, 95% confidence interval (CI): −0.853 to −0.014, p = 0.043) and white matter volume (−0.319, 95% CI: −0.619 to −0.018, p = 0.038) in patients with deficit schizophrenia compared to healthy controls. There is also statistically significant reduction in total brain volume (−0.212, 95% CI: −0.384 to −0.041, p = 0.015) and white matter volume (−0.283, 95% CI: −0.546 to −0.021, p = 0.034) in patients with non-deficit schizophrenia compared to healthy controls. Between patients with deficit and non-deficit schizophrenia, there were no statistically significant differences in volumetric findings across the various regions of interest.

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Brain neurodevelopmental markers related to the deficit subtype of schizophrenia

Cited by 20 publications

References 69 publications

Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

Brain morphologic changes in early stages of psychosis: Implications for clinical application and early intervention

Metacognitive capacity and negative symptoms in first episode psychosis: Evidence of a prospective relationship over a 3-year follow-up

Neuroanatomy of Patients with Deficit Schizophrenia: An Exploratory Quantitative Meta-Analysis of Structural Neuroimaging Studies

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