Brain nitric oxide synthases in the interleukin-1β-induced activation of hypothalamic-pituitary-adrenal axis

Gàdek-Michalska, A; Tadeusz, Joanna; Rachwalska, Paulina; Spyrka, Jadwiga; Bugajski, J

doi:10.1016/s1734-1140(12)70943-x

Cited by 29 publications

(22 citation statements)

References 35 publications

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“…injections of IL-1b (Sigma-Aldrich; dose: 5 mg/kg; volume: 1 ml/ kg; [18]) 2 times daily for 3 consecutive days. This pattern of IL-1b administration was chosen to mimic the timing of restraint stress sessions (see below).…”

Section: Animals and Treatmentmentioning

confidence: 99%

“…As intraperitoneal administration of IL-1b activates the HPA axis as well (e.g. [17,18]), in the present study we set out to investigate whether the effects of repeated restraint stress on the excitatory synaptic transmission and long-term plasticity could be mimicked by exogenous IL-1b. Next, we tested whether intraperitoneal administration of anti-IL-1b antibody would abolish the effects of repeated restraint stress on cortical synaptic transmission and plasticity.…”

Section: Introductionmentioning

confidence: 99%

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Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex

Bobula

Sowa

Hess

2015

Pharmacological Reports

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Section: Animals and Treatmentmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex

Bobula

Sowa

Hess

2015

Pharmacological Reports

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“…Probably, tadalafil affected ACTH secretion by inhibiting the PDE5 expressed in CNS (32), thus enhancing cGMP-mediated effects of NO on the hypothalamus-pituitary axis. In fact, NO-producing neurons are densely localized in PVN, and NO modulates the HPA axis by acting on different neuroendocrine pathways (5,14,24,30,33,45,46). Our hypothesis is supported by data from animals showing that: 1) NO exerts a tonic negative influence on the HPA axis (16), 2) NO may differently influence (e.g., increase or decrease) the activation of PVN during stress (24,27,51), and 3) in Yucatan swine, the inhibition of NO synthase increased the ACTH response to exercise (24).…”

Section: Discussionmentioning

confidence: 99%

The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise

Luigi¹,

Sgrò²,

Baldari

et al. 2012

American Journal of Physiology-Endocrinology and Metabolism

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The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise. Am J Physiol Endocrinol Metab 302: E972-E978, 2012. First published February 7, 2012 doi:10.1152/ajpendo.00573.2011.-Phosphodiesterase type 5 inhibitors may influence human physiology, health, and performance by also modulating endocrine pathways. We evaluated the effects of a 2-day tadalafil administration on adenohypophyseal and adrenal hormone adaptation to exercise in humans. Fourteen healthy males were included in a double-blind crossover trial. Each volunteer randomly received two tablets of placebo or tadalafil (20 mg/day with a 36-h interval) before a maximal exercise was performed. After a 2-wk washout, the volunteers were crossed over. Blood samples were collected at Ϫ30 and Ϫ15 min and immediately before exercise, immediately after, and during recovery (ϩ15, ϩ30, ϩ60, and ϩ90 min) for adrenocorticotropin (ACTH), ␤-endorphin, growth hormone (GH), prolactin, cortisol (C), corticosterone, dehydroepiandrosterone-sulfate (DHEAS), and cortisol binding globulin (CBG) assays. C-to-CBG (free cortisol index, FCI) and DHEAS-to-C ratios were calculated. Exercise intensity, perceived exertion rate, O2 consumption, and CO2 and blood lactate concentration were evaluated. ACTH, GH, C, corticosterone, and CBG absolute concentrations and/or areas under the curve (AUC) increased after exercise after both placebo and tadalafil. Exercise increased DHEAS only after placebo. Compared with placebo, tadalafil administration reduced the ACTH, C, corticosterone, and FCI responses to exercise and was associated with higher ␤-endorphin AUC and DHEAS-to-C ratio during recovery, without influencing cardiorespiratory and performance parameters. Tadalafil reduced the activation of the hypothalamus-pituitary-adrenal axis during exercise by probably influencing the brain's nitric oxide-and cGMP-mediated pathways. Further studies are necessary to confirm our results and to identify the involved mechanisms, possible health risks, and potential clinical uses. nitric oxide; exercise; tadalafil; adrenocorticotropin; cortisol THE SECRETION OF SYSTEMIC stress mediators (e.g., catecholamines, pituitary and adrenal hormones) increases after exercise depending on type, intensity, and duration of performed physical activity, individual characteristics, and associated psychological and metabolic stressors (7,17,21,29,36,48). In addition, many prohibited (e.g., anabolic hormones, glucocorticoids) and nonprohibited [e.g., nonsteroidal anti-inflammatory drugs, phosphodiesterases type 5 (PDE5) inhibitors (PDE5i), amino acids] substances, largely used or abused by athletes, have been shown to influence exercise performances and/or endocrine pathways at rest and during exercise (9 -11, 13, 19, 22).The PDE5i (e.g., sildenafil, tadalafil) widely used to treat erectile dysfunction in males have been shown to differently influence exercise capacity and/or energy metabolism during exercise, both in subj...

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Section: Salient Signal For the Systemmentioning

confidence: 99%

“…The prefrontal region of the brain is involved in planning, coordinating executive decisionmaking capacity, and regulating emotional and sentient experiences. Prefrontal cortex also regulates the hypothalamic-pituitary-adrenal axis of the stress response pathways [145].If the salience is less relevant to the organism's biology as an integrated dynamical system, the endogenous protective response may be more local and limited in scope. Non-salient NPs at low pulsed doses would have minimal transient effects either in terms of overall toxicity or therapeutic effects at the level of organizational scale of the organism.…”

mentioning

confidence: 99%

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Bell

Sarter

Koithan

et al. 2013

J Nanomed Nanotechol

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The purpose of the present paper is (a) to outline the self-organized, complex adaptive network nature of the organism as recipient of nanomedicines; (b) to propose several nonlinear endogenous amplification processes by which pulsed low doses of traditional, homeopathically-manufactured natural product nanomedicines may stimulate a return toward healthier function; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. Homeopathy is an over 200-year-old system of complementary and alternative medicine (CAM) that uses low doses of natural plant-, mineral-, and animal-sourced nanomedicines. Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. Agitation within glass containers at room temperature may also contribute nanosilica and nanosilicon as drug delivery vehicles and biological amplifiers. The medicine selection is matched to the recipient organism's systemic patterns of dysfunction and pulsed in the timing of the discrete doses. Endogenous amplification processes within the recipient organism may involve hormesis, time-dependent sensitization, and/or stochastic resonance. Effects are adaptive and systemically diffuse, i.e., causally indirect, rather than pharmacological and local, i.e., direct. All of these nonlinear response processes require interaction of the nanoparticle (NP) dose with the organism as a complex adaptive system. The pulsed NP dose serves as a low intensity salient danger signal for the organism to make network-wide adaptive changes that can lead to healing. The historically safe therapeutic approach of homeopathic nanomedicine dosing avoids risks of high, continuous doses and cumulative toxicity that contemporary nanomedicine researchers are now trying to solve while using NPs as if they were conventional bulk drugs. Integrating the insights, technical procedures, and clinical dosing approaches from modern and homeopathic nanomedicine could lead to major advances in the field for more effective and safer translational applications.NPs in homeopathic medicines [3]. NP concentrations are low, but measurable [3]. Like modern manufactured NPs [13], homeopathicallymanufactured medicines in solution also can exhibit aging effects [9,14]. These nanomedicines are delivered either in ethanolic liquids or sprayed and dried onto lactose or lactose/sucrose pellets for oral administration.Homeopathic manufacturing materials and methods are inherently "green" [15,16]. Previous papers have addressed the striking similarities between modern top-down mechanical attrition procedures for making nanoparticles (NPs) [17] and historical homeopathic medicine manufacturing methods and materials [15,[18][19][20][21]. These similarities include mechanically grinding source materials in lactose for hours and repeatedly agitating ethanol-water solutions containing the source Citation: Bell IR, Sarter B, Koithan M, Standish LJ, Banerji P, et al. (2013) Nonlinea...

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Brain nitric oxide synthases in the interleukin-1β-induced activation of hypothalamic-pituitary-adrenal axis

Abstract: The present study suggests that the IL-1β-induced transient stimulation of HPA axis activity is parallel in time and magnitude to the respective changes of nNOS in hypothalamus and prefrontal cortex, the brain structures involved in regulation of HPA axis activity.

Cited by 29 publications

References 35 publications

Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex

Anti-interleukin-1β antibody prevents the occurrence of repeated restraint stress-induced alterations in synaptic transmission and long-term potentiation in the rat frontal cortex

The phosphodiesterases type 5 inhibitor tadalafil reduces the activation of the hypothalamus-pituitary-adrenal axis in men during cycle ergometric exercise

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

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