Brain perfusion abnormalities in chronic obstructive pulmonary disease: comparison with cognitive impairment

Ortapamuk, Hulya; Naldöken, Seniha

doi:10.1007/bf02985621

Cited by 121 publications

(112 citation statements)

References 34 publications

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“…Various mechanisms including axonal remodeling, changes in dendritic spines, dendritic atrophy, synaptic plasticity (eg, synaptogenesis, synapse elimination, long-term potentiation/depression, or synapse turnover), changes in cell size, changes in oxygenation, and neural or glial cell genesis have been suggested to contribute to experience-dependent cortical plasticity. [44][45][46][47][48][49][50] Therefore, future studies with different methodology will be necessary to examine which of these potential mechanisms contribute to structural brain changes in COPD.…”

Section: Discussionmentioning

confidence: 99%

Structural Brain Changes in Patients With COPD

Esser

Stoeckel

Kirsten

et al. 2016

Chest

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Section: Discussionmentioning

confidence: 99%

Structural Brain Changes in Patients With COPD

Esser

Stoeckel

Kirsten

et al. 2016

Chest

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“…Therefore, continuous or even intermitent hypoxia (eforts, daily activities and sleep) may cause changes in brain perfusion, transient deicits in neurotransmiter metabolism in the central nervous system with changes in brain neurochemistry and structure [7,36,[40][41][42].…”

Section: Copd: Fundamental Pathophysiological Mechanisms Susceptible mentioning

confidence: 99%

Neurocognitive Impairment as Systemic Effects of COPD

Oancea¹,

Tudorache²,

Tudorache³

2018

COPD - An Update in Pathogenesis and Clinical Management

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Mild cognitive impairment (MCI), also known as incipient dementia, is characterized by the decline of cognitive function greater than expected for a certain age and educational level of the individual but not severe enough to interfere with their daily activities. However, this mild cognitive impairment afects several areas: visuospatial, memory, atention and luency and it is a signiicant concern because it decreases the quality of life and treatment adherence of these patients. On the other hand, evidence suggests that individuals with Chronic obstructive pulmonary disease (COPD) also present an important risk of falls: 46% of these patients experience a fall/year, sometimes with fatal consequences. Standard clinical balance measures can predict the risk of falls in this population. Moreover, increased inlammatory biomarkers are associated with the decrease of cognitive functions and a higher risk of falls in this population. Patients with COPD have a higher balance and cognitive impairment than their healthy peers Therefore, it is important to identify, assess and understand the relevance of these comorbidities in order to characterize the full clinical spectrum of COPD and adjust prevention strategies, given the devastating consequences of these problems.

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“…Despite the high prevalence in COPD subjects [48,49], cognitive dysfunction is often underestimated in clinical practice, and an altered cognition may reflect the pulmonary dysfunction [48] and/or hyposaturation of oxygen [50,51]. The improvement of saturation of oxygen can contribute to reduce cognitive dysfunction [8], while EAAs may directly influence cognition as several amino acids are precursors of brain neurotransmitters [8].…”

Section: B) Eaas and Quality Of Lifementioning

confidence: 99%

Essential amino acid supplementation in patients with severe COPD: a step towards home rehabilitation

Negro

Testa

Aquilani

et al. 2015

Monaldi Arch Chest Dis

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Background. Pulmonary Rehabilitation (“Rehabilitation”) can improve both lung function and quality of life in patients suffering from chronic obstructive pulmonary disease (COPD) even if only a very small proportion of patients have access to Rehabilitation. Supplementation of Essential Amino Acids (EAAs) might allow COPD patients to achieve some typical Rehabilitation outcomes such as a better physical performance and an improved health status. Methods. 88 COPD out-patients (GOLD class 3-4) with a body mass index (BMI) <23 Kg/m2 were randomised to receive EAAs (n=44) or placebo (n=44) for twelve weeks. Primary outcome measures were changes in both physical activities in daily life (measured by Sense Wear Armband in terms of mean steps walked in one week) and in quality of life (measured by the St George’s Respiratory Questionnaire, SGRQ). Results. After 12 weeks, the physical performance was significantly increased vs baseline only in patients who received EAAs (1140.33 ± 524.69 and 638.68 ± 662.1 steps/day, respectively; p=0.02), being also the comparison vs the placebo group highly significant (p=0.003). Similarly, the SGRQ score improved significantly only in EAA patients (69.35 ± 9.51 vs baseline 72.04 ± 8.62; p<0.01), and changes were significantly different from those measured in the placebo group (p<0.001). Furthermore, when compared to those who received placebo, EAAs patients significantly increased their fat-free mass (p=0.04), muscle strength (p<0.01), saturation of oxygen (p=0.05), serum albumin (p<0.001), and also ameliorated their original cognitive dysfunction (p=0.02). Conclusions. Oral supplementation with EAAs contribute to improve the daily-life performance in domiciliary severe COPD patients who can not enter any Rehabilitation programme, together with their quality of life; nutritional and cognitive status, and muscle strength.

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Brain perfusion abnormalities in chronic obstructive pulmonary disease: comparison with cognitive impairment

Cited by 121 publications

References 34 publications

Structural Brain Changes in Patients With COPD

Structural Brain Changes in Patients With COPD

Neurocognitive Impairment as Systemic Effects of COPD

Essential amino acid supplementation in patients with severe COPD: a step towards home rehabilitation

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