Brain perfusion correlates of medial temporal lobe atrophy and white matter hyperintensities in mild cognitive impairment

Caroli, Anna; Testa, Cristina; Geroldi, Cristina; Nobili, Flavio; Guerra, Ugo Paolo; Bonetti, Matteo; Frisoni, Giovanni B.

doi:10.1007/s00415-006-0498-z

Cited by 32 publications

(39 citation statements)

References 44 publications

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“…Both AD patients and control subjects underwent brain T1-weighted MRI in the Neuroradiology Department of the Città di Brescia Hospital, Brescia, as previously described [15,16] . MR images were processed with SPM2 following an optimized voxel-based morphometry protocol, described in detail elsewhere [18] .…”

Section: Mr Imagingmentioning

confidence: 99%

“…To achieve a precise normalization, we generated a study-specific PET template using both PET and MR scans of all patients and control subjects under study, following a procedure described in detail elsewhere [15,16] . The creation of a study-specific template allows for better normalization, since low uptake in ventricular structures and cortical hypometabolism (frequently present in elderly patients) are accounted for.…”

Section: Pet Processing Protocolmentioning

confidence: 99%

“…Briefly, customized prior probability maps were computed for gray matter (GM), WM and CSF [2] . The original MR images were normalized to a customized high-resolution MR template [15] through affine and nonlinear transformations; then, they were segmented into GM, WM and CSF using the customized priors, masked to remove non-brain tissue voxels, modulated, and finally smoothed with a 12-mm isotropic Gaussian kernel [19] . Only GM images were used in the statistical analysis.…”

Section: Mr Imagingmentioning

confidence: 99%

“…For each coregistered PET scan, we set the origin to the anterior commissure with SPM2 [17] , using the pertinent MR image as a reference, and we processed all scans with SPM2 according to an optimized processing protocol originally developed for SPECT and described in detail elsewhere [9,15,16] . Briefly, we normalized PET data through a double-stage spatial normalization, masked to remove scalp-facial activity, and we smoothed the results at 12 mm full-width-half-maximum (FWHM).…”

Section: Pet Processing Protocolmentioning

confidence: 99%

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Metabolic Compensation and Depression in Alzheimer’s Disease

Caroli

Lorenzi

Geroldi

et al. 2010

Dement Geriatr Cogn Disord

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Background/Aims: The aim of this study was to map metabolic compensation and depression in Alzheimer’s disease (AD) on a voxel-by-voxel basis. Methods: Twenty-one healthy elderly subjects and 25 AD patients underwent cerebral MR and FDG-PET imaging. All images were processed with SPM2, and whole-brain gray matter (GM) atrophy and hypometabolism maps were computed. Metabolic compensation and depression were assessed using Biological Parametric Mapping software. Results: GM atrophy and hypometabolism mapped to similar regions, with varying degrees of severity. Significant metabolic compensation was found in the amygdala, while exceeding hypometabolism was mainly located in the posterior cingulate cortex. Conclusion: Metabolic depression can be due to both distant effects of atrophy and to additional hypometabolism-inducing factors, such as amyloid deposition. Conversely, metabolic compensation could reflect spared synaptic plasticity of the surviving neurons. The investigation of the metabolic compensation mechanism could help in the comprehension of the AD underlying pathology.

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Section: Mr Imagingmentioning

confidence: 99%

Section: Pet Processing Protocolmentioning

confidence: 99%

Section: Mr Imagingmentioning

confidence: 99%

Section: Pet Processing Protocolmentioning

confidence: 99%

See 2 more Smart Citations

Metabolic Compensation and Depression in Alzheimer’s Disease

Caroli

Lorenzi

Geroldi

et al. 2010

Dement Geriatr Cogn Disord

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“…Thus, largescale studies of AD-related hippocampal atrophy are often impractical [39]. A number of studies were published where the visual rating scale was used in memory clinic population [40][41][42][43][44][45][46][47]. However, the scale, although simple to use and suitable for a clinical application, was not designed to detect atrophy progression on serial imaging; its quantized nature makes it insensitive to subtle changes over time [44].…”

Section: Automatic Methodsmentioning

confidence: 99%

Automatic Morphological Analysis of Medial Temporal Lobe

Chincarini¹,

Corosu²,

Gemme³

et al. 2010

TONMEDJ

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Abstract:Research in Alzheimer's disease (AD) has seen a tremendous growth of candidate biomarkers in the last decade. The role of such established or putative biomarkers is to allow an accurate diagnosis of AD, to infer about its prognosis, to monitor disease progression and evaluate changes induced by disease-modifying drugs. An ideal biomarker should detect a specific pathophysiological feature of AD, not present in the healthy condition, in other primary dementias, or in confounding conditions. Besides being reliable, a biomarker should be detectable by means of procedures which must be relatively non-invasive, simple to perform, widely available and not too expensive. At present, no candidate meets these requirements representing the high standards aimed at by researchers. Among others, various morphological brain measures performed by means of magnetic resonance imaging (MRI), ranging from the total brain volume to some restricted regions such as the hippocampal volume, have been proposed. Nowadays the efforts are directed toward finding an automated, unsupervised method of evaluating atrophy in some specific brain region, such as the medial temporal lobe (MTL). In this work we provide an extensive review of the state of the art on the automatic and semi-automatic image processing techniques for the early assessment of patients at risk of developing AD. Our main focus is the relevance of the morphological analysis of MTL, and in particular of the hippocampal formation, in making the diagnosis of AD and in distinguishing it from other dementias.

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Current awareness in geriatric psychiatry

2008

Int J Geriat Psychiatry

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Reviews; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

show abstract

Brain perfusion correlates of medial temporal lobe atrophy and white matter hyperintensities in mild cognitive impairment

Cited by 32 publications

References 44 publications

Metabolic Compensation and Depression in Alzheimer’s Disease

Metabolic Compensation and Depression in Alzheimer’s Disease

Automatic Morphological Analysis of Medial Temporal Lobe

Current awareness in geriatric psychiatry

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