Brain permeable curcumin-based pyrazoline analogs: MAO inhibitory and antioxidant activity

Cu(II)-Catalyzed Aminocyclization of N-Propargyl Hydrazones to Substituted Pyrazolines

“…Conventionally, pyrazolines could be synthesized via condensation of hydrazines with α,β-unsaturated aldehydes or ketones and a 1,3-dipolar cycloaddition reaction. − However, this approach suffers from poor selectivity, functional group tolerance, and sometimes harsh reaction conditions. Most importantly, N-sulfonyl and N-acyl pyrazolines having various substituents attached to sulfonyl and acyl groups (Figure ) have numerous biological applications, ,− which could not be retrieved by using the classical method. To address these challenges, the advancement of [3 + 2] − and [4 + 1] − cycloaddition reactions has been developed in later stages.…”