Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data

Tirelli, Umberto; Chierichetti, Franca; Tavio, Marcello; Simonelli, Cecilia; Bianchin, Gianluigi; Zanco, Pierluigi; Ferlin, G

doi:10.1016/s0002-9343(98)00179-x

Cited by 119 publications

(79 citation statements)

References 17 publications

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“…All investigations performed thus far have assessed functional brain activity during resting conditions and they generally have produced conflicting results. However, two studies documented relatively low rCBF levels in the brainstem among these patients [43,44]. Silverman et al [45] reported that acute pain produced by rectal balloon distention generated different patterns of brain activation in IBS patients and healthy controls.…”

Section: Pain Induction Studiesmentioning

confidence: 99%

Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

et al. 2000

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This paper examines the use of neuroimaging to measure change in regional cerebral blood flow (rCBF) produced by pain in patients with fibromyalgia and in healthy individuals. Fibromyalgia patients differ from healthy persons in rCBF distribution in several brain structures involved in pain processing and pain modulation both at rest and during experimental pain induction. These abnormalities may contribute to abnormal pain sensitivity as well as the maladaptive pain behaviors that characterize many patients with fibromyalgia. We anticipate that future neuroimaging studies will enhance our understanding of abnormal pain sensitivity and of pain management interventions aimed at altering central nervous system function in patients with fibromyalgia.

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Section: Pain Induction Studiesmentioning

confidence: 99%

Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

et al. 2000

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“…In 26 patients with chronic fatigue syndrome, Siessmeier et al showed that the cingulate gyrus and the adjacent mesial cortex were involved bilaterally in most patients (28). Significant hypometabolism in the right mediofrontal cortex and brain stem was described by Tirelli et al in 18 patients with chronic fatigue syndrome (29). In further study, it will be interesting to use, as a control group, patients with fibromyalgia or patients with chronic fatigue syndrome to eliminate any cerebral metabolic changes associated with the pain or fatigue sensation.…”

Section: Discussionmentioning

confidence: 98%

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Gucht¹,

Sebaiti²,

Guedj³

et al. 2016

J Nucl Med

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The aim of this study was to characterize brain metabolic abnormalities in patients with macrophagic myofascitis (MMF) and the relationship with cognitive dysfunction through the use of PET with 18 F-FDG. Methods: 18 F-FDG PET brain imaging and a comprehensive battery of neuropsychological tests were performed in 100 consecutive MMF patients (age [mean 6 SD], 45.9 6 12 y; 74% women). Images were analyzed with statistical parametric mapping (SPM12). Through the use of analysis of covariance, all 18 F-FDG PET brain images of MMF patients were compared with those of a reference population of 44 healthy subjects similar in age (45.4 6 16 y; P 5 0.87) and sex (73% women; P 5 0.88). The neuropsychological assessment identified 4 categories of patients: those with no significant cognitive impairment (n 5 42), those with frontal subcortical (FSC) dysfunction (n 5 29), those with Papez circuit dysfunction (n 5 22), and those with callosal disconnection (n 5 7). Results: In comparison with healthy subjects, the whole population of patients with MMF exhibited a spatial pattern of cerebral glucose hypometabolism (P , 0.001) involving the occipital lobes, temporal lobes, limbic system, cerebellum, and frontoparietal cortices, as shown by analysis of covariance. The subgroup of patients with FSC dysfunction exhibited a larger extent of involved areas (35,223 voxels vs. 13,680 voxels in the subgroup with Papez circuit dysfunction and 5,453 voxels in patients without cognitive impairment). Nonsignificant results were obtained for the last subgroup because of its small population size. Conclusion: Our study identified a peculiar spatial pattern of cerebral glucose hypometabolism that was most marked in MMF patients with FSC dysfunction. Further studies are needed to determine whether this pattern could represent a diagnostic biomarker of MMF in patients with chronic fatigue syndrome and cognitive dysfunction.

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“…Подобные данные получены также в исследованиях с применением позитронно-эмиссионной томографии (ПЭТ) с 15О-меченной водой и 18F-дезоксиглюкозой [31,53]. Выявлены снижение регионального кровотока в тех же областях, что и при SPECT, а также гипометаболизм в ме-диофронтальных отделах коры головного мозга и стволе мозга, обнаружение которого даже предполагается для ис-пользования в качестве диагностического маркера СХУ in vivo.…”

Section: '2010unclassified

Sindrom khronicheskoy ustalosti: sovremennye predstavleniya ob etiologii

Pigarova¹,

Плещева²,

Дзеранова³

et al. 2010

Obes. metabol.

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Chronic fatigue syndrome is a disease of unexplained feeling of profound fatigue lasting for more than 6 months. This fatigue is not relieved even after prolonged rest and is exacerbated after physical or mental work. More than 3000 scientific studies had proved that chronic fatigue syndrome is not a form of depression or hypochondria. It is a real somatic illness that results in professional, social and individual desadaptation. This article summarizes the contemporary etiological conceptions of this condition.

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Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data

Cited by 119 publications

References 17 publications

Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Sindrom khronicheskoy ustalosti: sovremennye predstavleniya ob etiologii

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Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data

Cited by 119 publications

References 17 publications

Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

Use of neuroimaging to understand abnormal pain sensitivity in fibromyalgia

Brain 18F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis

Sindrom khronicheskoy ustalosti: sovremennye predstavleniya ob etiologii

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Brain ¹⁸F-FDG PET Metabolic Abnormalities in Patients with Long-Lasting Macrophagic Myofascitis