Brain Re-irradiation for Breast Cancer Patients With Brain Metastasis After Whole Brain Radiation Therapy: Effect of Epidermal Growth Factor Receptor-2 Status on Clinical Outcome

Lai, Shenghan; Huang, Chi‐Cheng; Wang, C.; Chen, Y.; Lan, Keng Hsueh; Cheng, Ann‐Lii; Kuo, Sung‐Hsin

doi:10.1016/j.ijrobp.2013.06.632

Cited by 1 publication

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“…In another retrospective analysis, the authors assessed outcomes of 40 patients with BCBM who experienced intracranial progression after WBRT and received secondary radiotherapy [ 35 ]. A total of 12 patients received salvage SRS, 9 patients underwent FSRT, and 19 patients were irradiated with repeated WBRT.…”

Section: Available Options Of Local Salvage Treatment In Various Clin...mentioning

confidence: 99%

Salvage Treatment for Progressive Brain Metastases in Breast Cancer

Spałek

Mandat

2022

Cancers

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Survival of patients with breast cancer has increased in recent years due to the improvement of systemic treatment options. Nevertheless, the occurrence of brain metastases is associated with a poor prognosis. Moreover, most drugs do not penetrate the central nervous system because of the blood–brain barrier. Thus, confirmed intracranial progression after local therapy is especially challenging. The available methods of salvage treatment include surgery, stereotactic radiosurgery (SRS), fractionated stereotactic radiotherapy (FSRT), whole-brain radiotherapy, and systemic therapies. This narrative review discusses possible strategies of salvage treatment for progressive brain metastases in breast cancer. It covers possibilities of repeated local treatment using the same method as applied previously, other methods of local therapy, and options of salvage systemic treatment. Repeated local therapy may provide a significant benefit in intracranial progression-free survival and overall survival. However, it could lead to significant toxicity. Thus, the choice of optimal methods should be carefully discussed within the multidisciplinary tumor board.

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Section: Available Options Of Local Salvage Treatment In Various Clin...mentioning

confidence: 99%