Brain reactivity to unpleasant stimuli is associated with severity of posttraumatic stress symptoms.

Lobo, Isabela; David, Isabel A.; Figueira, Ivan; Campagnoli, Rafaela R.; Volchan, Eliane; Pereira, Mirtes Garcia; Oliveira, Letícia

doi:10.1016/j.biopsycho.2014.09.002

Cited by 45 publications

(31 citation statements)

References 82 publications

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“…This evidence is consistent with a study that found that compared with healthy control subjects, traumatized groups (with and without PTSD) exhibited increased P300 and late positive complex amplitudes in response to trauma-specific questions (Wessa et al, 2006). Likewise, a group analysis performed by Lobo et al (2014) indicated that students with more severe PTSS (high-PTSS group) had significantly greater LPP compared to students with less severe symptoms (low-PTSS group). The results were strengthened by joining the two groups in a multiple regression model, which found that two PCA factor scores that corresponded to the LPP were able to predict the severity of PTSS.…”

Section: Erp Studiessupporting

confidence: 89%

“…It is possible that mixed-trauma samples prevent significant results from being achieved in the EEG studies. In fact, most of the studies that used a mixedtrauma sample found no significant correlation between EEG parameters and the severity of symptoms-very few exceptions were found (Lobo et al, 2014;Veltmeyer et al, 2009Veltmeyer et al, , 2006.…”

Section: Discussionmentioning

confidence: 76%

“…In emotion paradigms, slow wave activity indicates elevated positivity in response to highly arousing stimuli (Cuthbert et al, 2000;Mocaiber et al, 2010Mocaiber et al, , 2009). In fact, using distinct tasks, three studies found positive correlations between these variables: increased severity of PTSS was related to greater P3-family ERP amplitudes (Covey et al, 2013;Lobo et al, 2014;Veltmeyer et al, 2009). This evidence is consistent with a study that found that compared with healthy control subjects, traumatized groups (with and without PTSD) exhibited increased P300 and late positive complex amplitudes in response to trauma-specific questions (Wessa et al, 2006).…”

Section: Erp Studiesmentioning

confidence: 93%

“…Additional correlations with the years of experience as an officer and the number of past incidents that could potentially result in a traumatic experience were not related to the P3 amplitude. These results suggest that there are alterations in the brain mechanisms of inhibitory control in trauma-exposed police officers that are most likely due to the severity of PTSS in populations with sub-threshold PTSD (with symptoms but without a diagnosis) Lobo et al (2014). studied a sample of traumatized college students with PTSS engaged in an emotional task to investigate another P3-family ERP: the late positive potential (LPP), which is an emotional reactivity index.…”

mentioning

confidence: 98%

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EEG correlates of the severity of posttraumatic stress symptoms: A systematic review of the dimensional PTSD literature

Lobo

Portugal

Figueira

et al. 2015

Journal of Affective Disorders

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Section: Erp Studiessupporting

confidence: 89%

Section: Discussionmentioning

confidence: 76%

Section: Erp Studiesmentioning

confidence: 93%

mentioning

confidence: 98%

See 2 more Smart Citations

EEG correlates of the severity of posttraumatic stress symptoms: A systematic review of the dimensional PTSD literature

Lobo

Portugal

Figueira

et al. 2015

Journal of Affective Disorders

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“…High PTSS severity has also been linked with enhanced LPP amplitude during negative picture viewing among trauma‐exposed undergraduates (Lobo et al, ), whereas no significant differences were found between youth with and without PTSD (Grasso & Simons, ). To summarize, positive (Fitzgerald et al, ; Lobo et al, ), inverse (DiGangi et al, ; MacNamara et al, ), and null associations (Grasso & Simons, ) between PTSS and threat‐related LPP modulation have been found.…”

Section: Introductionmentioning

confidence: 99%

Nonlinear relations between post‐traumatic stress symptoms and electrocortical reactivity during emotional face processing in combat‐exposed veterans

et al. 2019

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Combat‐related post‐traumatic stress symptoms (PTSS) are prevalent among recently deployed veterans, making identification of biomarkers of PTSS in this population a public health priority. Given the link between threat processing neurobiology and PTSS, the threat‐related late positive potential (LPP), an ERP reflective of attentional processing sensitive to emotion and its regulation, may have utility as a cost‐effective biomarker. Existing PTSS/threat‐related LPP findings are mixed, possibly due to variability in PTSS across samples, but this has never been explicitly tested. To address this gap, LPP amplitudes to angry, fearful, and happy emotional face stimuli were recorded among 81 combat‐exposed veterans at a VA hospital. A quadratic relationship between self‐reported PTSS and LPP amplitude modulation by angry faces emerged such that greater PTSS was related to a decreased LPP response to angry faces among veterans with subthreshold PTSD and an enhanced LPP response to angry faces among veterans with probable PTSD. These results suggest that prior mixed findings may be due to variability in PTSS severity. In addition, exploratory moderation analysis revealed that PTSS was positively associated with late LPP modulation for veterans reporting low cognitive reappraisal use and negatively associated with late LPP modulation for veterans reporting high cognitive reappraisal use. All results were specific to the 1,000–3,000 ms LPP time window. Thus, the functional nature of LPP modulation by direct threat cues may depend upon PTSS severity and/or related variables (e.g., cognitive reappraisal utilization).

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Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample

Granros

MacNamara

Klumpp

et al. 2022

Depression and Anxiety

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Background: Internalizing psychopathologies (IPs) are highly comorbid and exhibit substantial overlap, such as aberrant affective reactivity. Neural reactivity to emotional images, measured via the late positive potential (LPP) event-related potential (ERP) component, has been utilized to index affective reactivity in IPs. The LPP is often examined in isolation with a specific disorder, ignoring overlap between IPs. The current study examined how transdiagnostic IP symptom dimensions relate to neural affective reactivity in a highly comorbid patient sample. Methods: Participants (N = 99) completed a battery of IP symptom assessments as well as a target categorization task while viewing pleasant, unpleasant, and neutral images during electroencephalography recording. ERPs to each image valence were averaged from 400 to 1000 ms following picture onset at pooled centroparietal and occipital electrodes to calculate the LPP. A principal components analysis performed on the IP symptom measures resulted in two factors: affective distress/ misery and fear-based anxiety.Results: Fear-based anxiety was associated with enhanced LPP reactivity to unpleasant, but not pleasant, images. Distress/misery was related to attenuated average LPP reactivity across images.Conclusions: Results revealed a dissociable effect of IP symptom factors in a transdiagnostic sample such that enhanced reactivity to negative images was specific to enhanced fear-based anxiety symptoms while distress/misery symptoms predicted blunted affective reactivity. Neural affective reactivity may serve as an objective biological marker to elucidate the nature of psychological concerns in individuals with comorbid IPs.

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Brain reactivity to unpleasant stimuli is associated with severity of posttraumatic stress symptoms.

Cited by 45 publications

References 82 publications

EEG correlates of the severity of posttraumatic stress symptoms: A systematic review of the dimensional PTSD literature

EEG correlates of the severity of posttraumatic stress symptoms: A systematic review of the dimensional PTSD literature

Nonlinear relations between post‐traumatic stress symptoms and electrocortical reactivity during emotional face processing in combat‐exposed veterans

Neural reactivity to affective stimuli and internalizing symptom dimensions in a transdiagnostic patient sample

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