Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis

Lee, Jin-Seok; Sato, Wakiro; Son, Chang-Gue

doi:10.1016/j.autrev.2023.103484

Cited by 8 publications

(6 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Neuroinflammation is another proposed neuropathophysiological mechanism in ME/CFS [210]. High-dose thiamine has demonstrated fatigue reduction in neuroinflammatory conditions, and it has been posited that it may act similarly to carbonic anhydrase inhibitors in reducing intracranial hypertension, which may warrant investigation in a CT for ME/CFS [211,212].…”

Section: Future Directionsmentioning

confidence: 99%

Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

Seton,

Espejo-Oltra,

Giménez-Orenga

et al. 2024

JCM

View full text Add to dashboard Cite

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic, debilitating, and multi-faceted illness. Heterogenous onset and clinical presentation with additional comorbidities make it difficult to diagnose, characterize, and successfully treat. Current treatment guidelines focus on symptom management, but with no clear target or causative mechanism, remission rates are low, and fewer than 5% of patients return to their pre-morbid activity levels. Therefore, there is an urgent need to undertake robust clinical trials to identify effective treatments. This review synthesizes insights from clinical trials exploring pharmacological interventions and dietary supplements targeting immunological, metabolic, gastrointestinal, neurological, and neuroendocrine dysfunction in ME/CFS patients which require further exploration. Additionally, the trialling of alternative interventions in ME/CFS based on reported efficacy in the treatment of illnesses with overlapping symptomology is also discussed. Finally, we provide important considerations and make recommendations, focusing on outcome measures, to ensure the execution of future high-quality clinical trials to establish clinical efficacy of evidence-based interventions that are needed for adoption in clinical practice.

show abstract

Section: Future Directionsmentioning

confidence: 99%

Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

Seton,

Espejo-Oltra,

Giménez-Orenga

et al. 2024

JCM

View full text Add to dashboard Cite

show abstract

“…In this article, relationship based include determination strategy (CFS) is used for include choice. The CFS strategy assesses a subset of features and chooses as it were particular highlights that have a tall relationship with a course occasion [43]. CFS positions are highlights that will be calculated utilizing an exploratory assessment work based on relationship.…”

Section: Proposed Modelmentioning

confidence: 99%

“…CFS disposes of unessential qualities that are less pertinent to the lesson name. The CFS basis is calculated utilizing condition 1 [43]:…”

Section: Proposed Modelmentioning

confidence: 99%

Facial and speech Emotional Recognition based on Improved Deep Model

Shahrestani,

Motamed,

Yamaghani

2024

Preprint

View full text Add to dashboard Cite

In recent years, emotion recognition as a new method for natural human-computer interaction has attracted the attention of many researchers. Because the automatic recognition of emotion from speech or facial expressions alone has uncertainties; it is expected that emotion recognition based on the fusion of audio-visual information can be done with better accuracy. The purpose of this article is to present an efficient method for emotion recognition from emotional speech signals and images of emotional facial expressions, based on the SOAR cognitive science model. In this article, in order to implement the subsections of the SOAR model, stochastic deep learning has been used. In the proposed model, the RAVDESS database is used for testing and evaluation, and we have achieved 89.44% accuracy in the evaluation.

show abstract

“…ME/CFS, also known as Systemic Exertion Intolerance Disease (SEID), represents one of the most severe dysfunctions involving the limbic-reticular complex and its connections with the frontal cortex and other neocortical areas [ 216 , 217 , 218 , 219 ]. Although ME/CFS and similar conditions are not the most typical manifestations, they are among the most concerning for public health due to the profound chronic fatigue and intolerance to physical and psycho-emotional stress that often lead to disability in affected individuals.…”

Section: Local Phenomena Of Low-grade Inflammation In Lc and Other Vi...mentioning

confidence: 99%

“…The etiology and pathogenesis of ME/CFS remain largely unclear. However, increasing evidence suggests that ME/CFS is not merely a neuropsychiatric disorder but also involves significant contributions from the immune system and low-grade neuroinflammation (neuroparainflammation) [ 219 , 220 ]. In 2015, the Committee on Diagnostic Criteria for ME/CFS redefined the disorder as SEID and specified diagnostic criteria [ 221 ], which include: A significant reduction in the ability to engage in pre-illness levels of activity that persists for more than six months, accompanied by fatigue.…”

Section: Local Phenomena Of Low-grade Inflammation In Lc and Other Vi...mentioning

confidence: 99%

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Gusev,

Sarapultsev

2024

IJMS

View full text Add to dashboard Cite

Long COVID (LC), also referred to as Post COVID-19 Condition, Post-Acute Sequelae of SARS-CoV-2 Infection (PASC), and other terms, represents a complex multisystem disease persisting after the acute phase of COVID-19. Characterized by a myriad of symptoms across different organ systems, LC presents significant diagnostic and management challenges. Central to the disorder is the role of low-grade inflammation, a non-classical inflammatory response that contributes to the chronicity and diversity of symptoms observed. This review explores the pathophysiological underpinnings of LC, emphasizing the importance of low-grade inflammation as a core component. By delineating the pathogenetic relationships and clinical manifestations of LC, this article highlights the necessity for an integrated approach that employs both personalized medicine and standardized protocols aimed at mitigating long-term consequences. The insights gained not only enhance our understanding of LC but also inform the development of therapeutic strategies that could be applicable to other chronic conditions with similar pathophysiological features.

show abstract

Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: A systematic review and meta-analysis

Cited by 8 publications

References 40 publications

Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

Advancing Research and Treatment: An Overview of Clinical Trials in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Future Perspectives

Facial and speech Emotional Recognition based on Improved Deep Model

Exploring the Pathophysiology of Long COVID: The Central Role of Low-Grade Inflammation and Multisystem Involvement

Contact Info

Product

Resources

About