“…Previous studies have reported a critical link between white matter integrity in the corpus callosum and both cognitive and mobility measures (e.g., Bhadelia et al, 2009;Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012;Ryberg et al, 2011;Ryberg et al, 2007). Of particular relevance, atrophy in the splenium -a posterior region of the corpus callosum -appears to be most associated with reduced general mobility (e.g., Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012) as measured by the Short Physical Performance Battery (SPPB) (Guralnik, Ferrucci, Simonsick, Salive, & Wallace, 1995). Importantly, the splenium is implicated in interhemispheric transfer of visual and somatosensory information from occipital and posteriorinferior parietal cortices (e.g., Park et al, 2008); this information is fundamental for the integration of visual and spatial inputs to motor responses (e.g., Moscufo et al, 2011).…”