2011
DOI: 10.1016/j.neurobiolaging.2009.04.010
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Brain regional lesion burden and impaired mobility in the elderly

Abstract: This study investigated the relationship of brain white matter (WM) lesions affecting specific neural networks with decreased mobility in ninety-nine healthy community-dwelling subjects ≥75-years old prospectively enrolled by age and mobility status. We assessed lesion burden in the genu, body and splenium of corpus callosum; anterior, superior and posterior corona radiata; anterior and posterior limbs of internal capsule; corticospinal tract; and superior longitudinal fasciculus. Burden in the splenium of cor… Show more

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Cited by 51 publications
(82 citation statements)
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“…Previous studies have reported a critical link between white matter integrity in the corpus callosum and both cognitive and mobility measures (e.g., Bhadelia et al, 2009;Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012;Ryberg et al, 2011;Ryberg et al, 2007). Of particular relevance, atrophy in the splenium -a posterior region of the corpus callosum -appears to be most associated with reduced general mobility (e.g., Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012) as measured by the Short Physical Performance Battery (SPPB) (Guralnik, Ferrucci, Simonsick, Salive, & Wallace, 1995). Importantly, the splenium is implicated in interhemispheric transfer of visual and somatosensory information from occipital and posteriorinferior parietal cortices (e.g., Park et al, 2008); this information is fundamental for the integration of visual and spatial inputs to motor responses (e.g., Moscufo et al, 2011).…”
Section: Primary Findingmentioning
confidence: 99%
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“…Previous studies have reported a critical link between white matter integrity in the corpus callosum and both cognitive and mobility measures (e.g., Bhadelia et al, 2009;Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012;Ryberg et al, 2011;Ryberg et al, 2007). Of particular relevance, atrophy in the splenium -a posterior region of the corpus callosum -appears to be most associated with reduced general mobility (e.g., Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012) as measured by the Short Physical Performance Battery (SPPB) (Guralnik, Ferrucci, Simonsick, Salive, & Wallace, 1995). Importantly, the splenium is implicated in interhemispheric transfer of visual and somatosensory information from occipital and posteriorinferior parietal cortices (e.g., Park et al, 2008); this information is fundamental for the integration of visual and spatial inputs to motor responses (e.g., Moscufo et al, 2011).…”
Section: Primary Findingmentioning
confidence: 99%
“…Of particular relevance, atrophy in the splenium -a posterior region of the corpus callosum -appears to be most associated with reduced general mobility (e.g., Frederiksen et al, 2011;Moscufo et al, 2011;Moscufo et al, 2012) as measured by the Short Physical Performance Battery (SPPB) (Guralnik, Ferrucci, Simonsick, Salive, & Wallace, 1995). Importantly, the splenium is implicated in interhemispheric transfer of visual and somatosensory information from occipital and posteriorinferior parietal cortices (e.g., Park et al, 2008); this information is fundamental for the integration of visual and spatial inputs to motor responses (e.g., Moscufo et al, 2011). Within this context, our data suggests that reduced attentional facilitation may be a functional consequence of atrophy in the posterior corpus callosum in those at-risk for falls.…”
Section: Primary Findingmentioning
confidence: 99%
“…54 The lower limit of detection of WMH by experts in neuroradiology is approximately 0.2 to 0.3% of intracranial contents, and 0.5% is easily visible to the naked eye based on our experience. 8,54,65 Our cohort studies have demonstrated an increase of WMH volume from 0.99 to 1.47 to 1.7% of the intracranial contents volume from baseline to 2 and 4 years respectively. 8,54 This increase was even present in participants with normal mobility throughout the study period.…”
Section: 58mentioning
confidence: 78%
“…In our past work in this area, we have evaluated the progression of WMH over 2 and 4 years in a cohort of 95 patients 75 to 90 years (mean baseline age, 82 years) who had office and ambulatory BP and volumetric MRI. 54,65 Neither clinic BP nor changes in clinic BP predicted progression of WMH, while the 24 hours ambulatory BP and changes in ambulatory BP significantly correlated with both WMH volume (p < 0.04) and changes in WMH (p < 0.003). 54 Further analyses demonstrated associations for WMH and mobility indexes with level of systolic BP based on tertiles of the cohort -i.e., those in the higher (24 hours systolic BP = 144 mm Hg) ambulatory BP group showed increases in WMH and slower mobility compared with the middle tertile (ambulatory systolic BP = 130 mm Hg) ( Table 2).…”
Section: 58mentioning
confidence: 97%
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