2021
DOI: 10.1001/jamanetworkopen.2020.32236
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Brain Responses to Noxious Stimuli in Patients With Chronic Pain

Abstract: IMPORTANCE Functional neuroimaging is a valuable tool for understanding how patients with chronic pain respond to painful stimuli. However, past studies have reported heterogenous results, highlighting opportunities for a quantitative meta-analysis to integrate existing data and delineate consistent associations across studies. OBJECTIVETo identify differential brain responses to noxious stimuli in patients with chronic pain using functional magnetic resonance imaging (fMRI) while adhering to current best prac… Show more

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Cited by 19 publications
(24 citation statements)
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References 80 publications
(191 reference statements)
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“…The present study employed two different CBMA approaches (GingerALE and ABC) to determine whether chronic pain disorders are characterized by neurofunctional dysregulations during experimental pain induction. In contrast to two recent neuroimaging meta‐analyses, which, surprisingly, did not reveal convergent functional alterations in chronic pain disorders (Tanasescu et al, 2016; A. Xu et al, 2021), the present study shows robust evidence for altered neurofunctional processing in the left anterior insular cortex of chronic pain patients during experimental pain induction. Notably, functional abnormalities in the left anterior insula cortex were robustly confirmed on Dataset #1 with both ALE and ABC approaches, although with subtle differences, and on Dataset #2 with ABC.…”
Section: Discussioncontrasting
confidence: 99%
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“…The present study employed two different CBMA approaches (GingerALE and ABC) to determine whether chronic pain disorders are characterized by neurofunctional dysregulations during experimental pain induction. In contrast to two recent neuroimaging meta‐analyses, which, surprisingly, did not reveal convergent functional alterations in chronic pain disorders (Tanasescu et al, 2016; A. Xu et al, 2021), the present study shows robust evidence for altered neurofunctional processing in the left anterior insular cortex of chronic pain patients during experimental pain induction. Notably, functional abnormalities in the left anterior insula cortex were robustly confirmed on Dataset #1 with both ALE and ABC approaches, although with subtle differences, and on Dataset #2 with ABC.…”
Section: Discussioncontrasting
confidence: 99%
“…Early neuroimaging meta‐analyses performed on chronic pain suffered from a bias toward false‐positive results since they employed previous ALE versions (Eickhoff et al, 2017). However, two robust recent meta‐analyses conducted with LocaleALE (Tanasescu et al, 2016) and with the GingerALE updated version (A. Xu et al, 2021) did not determine robust neurofunctional differences between chronic pain patients and control individuals during experimental pain induction. The null findings in the previous studies (Tanasescu et al, 2016; A. Xu et al, 2021) might be explained by study selection criteria.…”
Section: Discussionmentioning
confidence: 99%
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