Brain Damage - Bridging Between Basic Research and Clinics 2012
DOI: 10.5772/36589
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Brain Restoration: A Function of Sleep

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Cited by 1 publication
(3 citation statements)
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“…Although we spend approximately a third of our life asleep, its explicit physiological and evolutionary function remains unclear with myriad hypotheses having been postulated . Two of the leading hypotheses are that sleep enables (i) the repair and clearance needed to correct and prevent neuronal damage (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(29)(30)(31)(32) and (ii) the neural reorganization necessary for learning and synaptic homeostasis (13)(14)(15)(16)(17)(18)(19)(20)(21). These hypotheses are compelling because neither of these processes can be easily achieved in waking states and there is supporting empirical evidence that they occur during sleep.…”
Section: Introductionmentioning
confidence: 99%
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“…Although we spend approximately a third of our life asleep, its explicit physiological and evolutionary function remains unclear with myriad hypotheses having been postulated . Two of the leading hypotheses are that sleep enables (i) the repair and clearance needed to correct and prevent neuronal damage (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(29)(30)(31)(32) and (ii) the neural reorganization necessary for learning and synaptic homeostasis (13)(14)(15)(16)(17)(18)(19)(20)(21). These hypotheses are compelling because neither of these processes can be easily achieved in waking states and there is supporting empirical evidence that they occur during sleep.…”
Section: Introductionmentioning
confidence: 99%
“…For instance, prolonged sleep deprivation can lead to death in rats (25), dogs (26), fruit flies (27), and even humans (28). These extreme cases are believed to result from damage to neuronal cells caused by metabolic processes that are not avoided or remedied because clearance of damaging agents and repair occur primarily during sleep (6,29). Moreover, a recent hypothesis related to neuronal damage from metabolic processes is that sleep drives metabolic clearance from the brain (7).…”
Section: Introductionmentioning
confidence: 99%
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