Brain single-nucleus transcriptomics highlights that polystyrene nanoplastics potentially induce Parkinson’s disease-like neurodegeneration by causing energy metabolism disorders in mice

Liang, Beibei; Huang, Yuji; Zhong, Yizhou; Li, Zhiming; Ye, Rongyi; Wang, Bo; Zhang, Bingli; Meng, Hao; Lin, Xi; Du, Junbao; Hu, Manjiang; Wu, Q. H.; Sui, Haixia; Yang, Xingfen; Huang, Zhenlie

doi:10.1016/j.jhazmat.2022.128459

Cited by 93 publications

(33 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MNPs may primarily induce mitochondrial dysfunction and energy metabolism disorders in neurons, particularly in excitatory neurons. Additionally, MNPs may cause disorders of ATP metabolism and mitochondrial and synaptic function regulation in astrocytes and may be involved in neurodegeneration [ 72 ].…”

Section: Toxicities Of Micro- and Nanoplastics On Mitochondriamentioning

confidence: 99%

Impact of Micro- and Nanoplastics on Mitochondria

Lee

Moon

et al. 2022

Metabolites

View full text Add to dashboard Cite

Mitochondria are highly dynamic cellular organelles that perform crucial functions such as respiration, energy production, metabolism, and cell fate decisions. Mitochondrial damage and dysfunction critically lead to the pathogenesis of various diseases including cancer, diabetes, and neurodegenerative and cardiovascular disorders. Mitochondrial damage in response to environmental contaminant exposure and its association with the pathogenesis of diseases has also been reported. Recently, persistent pollutants, such as micro- and nanoplastics, have become growing global environmental threats with potential health risks. In this review, we discuss the impact of micro- and nanoplastics on mitochondria and review current knowledge in this field.

show abstract

Section: Toxicities Of Micro- and Nanoplastics On Mitochondriamentioning

confidence: 99%

Impact of Micro- and Nanoplastics on Mitochondria

Lee

Moon

et al. 2022

Metabolites

View full text Add to dashboard Cite

show abstract

“…Similar to MP exposure, a determinant of Parkinson's disease progression is a loss of dopaminergic neurons in the brain (National Health Service, n.d.-b). Through testing on mice, nematodes, fish, and other organisms, MP exposure can result in the activation of inflammation through the immune response, neurotoxicity, oxidative stress, and transgenerational genetic effects through gene expression (Barboza, 2018;Liang et al, 2022;Mattsson et al, 2017;J. Shi et al, 2022;.…”

Section: Discussionmentioning

confidence: 99%

“…Shi et al, 2022;. All of these processes have been implicated in the progression of PD (Barboza, 2018;Liang et al, 2022;Mattsson et al, 2017;J. Shi et al, 2022;.…”

Section: Discussionmentioning

confidence: 99%

“…Many of the studies on MP exposure have used plastics types such as polystyrene and polypropylene. (Wu B 2019;Han 2019;Wang 2022;Lee, et al 2022;Chen, et al 2021;Liang, et al 2022) . Thus, there may be some inconsistency in the findings, considering that different chemicals within plastics can have different effects on the body.…”

Section: Discussionmentioning

confidence: 99%

“…PD is a disease in which one displays motor function disturbances: including tremors, changes in posture, and rigidity (Tolosa et al, 2021). In a study in which mice were repeatedly exposed to an oral dose of microplastics, researchers found changes in the blood brain barrier, a loss of dopaminergic neurons, and disrupted motor function, suggesting that MPs may play a role in the neurodegeneration found in Parkinson's disease (Liang et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Microplastic Exposure and the of Parkinson’s Disease

Shapiro¹,

Katchur

2023

J Stud Res

View full text Add to dashboard Cite

Microplastics (MPs) are small particles or fragments of plastic that have leaked into the environment and ecosystems in recent decades. Numerous animal studies have suggested that an organism’s exposure to microplastics may evoke responses from the body that are similar to the pathogenesis of human diseases. In particular, a collection of evidence has suggested that microplastics exposure may mimic Parkinson’s disease pathology (decreased dopaminergic neurons and interrupted motor function). Parkinson’s disease is an often progressive and fatal neurodegenerative disease that is defined by the degeneration of dopaminergic neurons in the brain; this degeneration leads to decreased motor function and abnormal motor movements. Studies have indicated that, upon entering the body, microplastics may trigger oxidative stress, organ inflammation, neurotoxicity, and transgenerational effects. Parkinson’s disease diagnoses are predicted to greatly increase in upcoming generations while microplastics continue to enter the environment at growing rates, inciting a point of concern for the human population and other organisms. In this review, the possible effects of organisms’ exposure to microplastics are explored through the review of animal studies and the comparison of these findings to the pathogenesis of Parkinson’s disease. By understanding the ways in which MPs affect the body and contribute to PD and other neurodegenerative disorders, the danger that MPs pose toward living organisms can be recognized, necessitate further research, and encourage preventative measures against the leakage of MPs into the environment.

show abstract