2010
DOI: 10.1186/1471-244x-10-79
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Brain size and brain/intracranial volume ratio in major mental illness

Abstract: BackgroundThis paper summarizes the findings of a long term study addressing the question of how several brain volume measure are related to three major mental illnesses in a Colorado subject group. It reports results obtained from a large N, collected and analyzed by the same laboratory over a multiyear period, with visually guided MRI segmentation being the primary initial analytic tool.MethodsIntracerebral volume (ICV), total brain volume (TBV), ventricular volume (VV), ventricular/brain ratio (VBR), and TB… Show more

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Cited by 29 publications
(22 citation statements)
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References 29 publications
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“…HC = BD > SZ in hippocampusSalisbury et al 116 200732/20/0/21PFEMedicatedHeschl gyriROI (manual tracing)1.5SZ < HC = BD in left heschl gyrus gray matter volumesNakamura et al 117 200736/29/0/34PFEMedicatedNeocortexROI (manual tracing)1.5HC > SZ = BD neocortical gray matter volumesMorgan et al 118 200758/44/0/29PFEMedicatedWhole brainVBM1.5No group differencesFrazier et al 42 200829/20/0/54P/NPChronicMedicatedSubcortical volumesROI (manual tracing)1.5No group differences in hippocampus and amygdala volumesKoo et al 52 200840/39/0/41PFEMedicatedCingulate gyrusROI (manual tracing)1.5HC > SZ in subgenual, anterostratal, anterodorsal, and posterior subregions. HC > BD in the subgenual subregionKillgore et al 43 200920/19/0/11Acute psychosisMedicatedCerebrum, amygdala, hippocampusROI (manual tracing)1.5SZ < BD = HC total brain volume, SCZ = HC = BD in amygdala and hippocampus volumeReite et al 119 201089/58/26/51ChronicMedicatedWhole brainmanual tracing and semiautomated1.5/3No group differencesMolina et al 48 201124/38/0/19P/NPChronicMedicatedWhole brainVBM1.5No differences in SZ vs BD. SZ < HC in medial frontal lobe and basal ganglia.…”
Section: Resultsmentioning
confidence: 99%
“…HC = BD > SZ in hippocampusSalisbury et al 116 200732/20/0/21PFEMedicatedHeschl gyriROI (manual tracing)1.5SZ < HC = BD in left heschl gyrus gray matter volumesNakamura et al 117 200736/29/0/34PFEMedicatedNeocortexROI (manual tracing)1.5HC > SZ = BD neocortical gray matter volumesMorgan et al 118 200758/44/0/29PFEMedicatedWhole brainVBM1.5No group differencesFrazier et al 42 200829/20/0/54P/NPChronicMedicatedSubcortical volumesROI (manual tracing)1.5No group differences in hippocampus and amygdala volumesKoo et al 52 200840/39/0/41PFEMedicatedCingulate gyrusROI (manual tracing)1.5HC > SZ in subgenual, anterostratal, anterodorsal, and posterior subregions. HC > BD in the subgenual subregionKillgore et al 43 200920/19/0/11Acute psychosisMedicatedCerebrum, amygdala, hippocampusROI (manual tracing)1.5SZ < BD = HC total brain volume, SCZ = HC = BD in amygdala and hippocampus volumeReite et al 119 201089/58/26/51ChronicMedicatedWhole brainmanual tracing and semiautomated1.5/3No group differencesMolina et al 48 201124/38/0/19P/NPChronicMedicatedWhole brainVBM1.5No differences in SZ vs BD. SZ < HC in medial frontal lobe and basal ganglia.…”
Section: Resultsmentioning
confidence: 99%
“…Studies also had to have specifically utilized the VBR as their measure of ventricular size and reported mean and standard deviations for mean VBR in both samples – as was done similarly in Van Horn and McManus. The earliest journal article considered in this updated collection of studies was that of Shiraishi et al (1990) while the latest journal article examined was that of Reite et al (2010). Journal impact factor was not used as a basis for article inclusion/exclusion from our study but was used as a potential moderator variable (see below).…”
Section: Methodsmentioning
confidence: 99%
“…Consequently, only data on comparison between BM (or volume converted into mass; see Table 1) and CC were used. Those data are from K€ oppel (1897), Mobilio (1915), R€ ohrs and Ebinger (2001), Knudsen et al (2002), Shoshani et al (2006), and Reite et al (2010) (Table 1). As far as it was made explicit in this literature, only adult, healthy, and non-pregnant specimens for which both BM and CC could be directly used or estimated were selected.…”
Section: Methodsmentioning
confidence: 95%
“…A similar conclusion has been supported elsewhere, by R€ ohrs and Ebinger (2001) in land mammals using a similar data set, and by Ruff et al (1997) in primates. On the other hand, Isler et al (2008) found that brain volume scales isometrically with respect to CC in non-human primates, but their data set does not include humans, in which CC deviates strongly from BM (Reite et al, 2010;Zollikofer and De Le on, 2013).…”
Section: Scaling Of Bm To CCmentioning
confidence: 93%