Brain SPECT Imaging in Complex Psychiatric Cases: An Evidence-Based, Underutilized Tool

Amen, Daniel; Trujillo, Manuel; Newberg, Andrew; Willeumier, K; Tarzwell, Robert; Wu, Joseph C.; Chaitin, Barry F.

doi:10.2174/1874440001105010040

Cited by 47 publications

(36 citation statements)

References 58 publications

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“…Depending on the tracer used, SPECT imaging can be useful for studying cerebral blood flow (CBF), dopamine transporter function, serotonin transporter function, as well as other processes [15]–[17]. Several studies have also shown that SPECT imaging of CBF can be helpful in TBI patients [18].…”

Section: Introductionmentioning

confidence: 99%

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

et al. 2014

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BackgroundThis study evaluated the clinical interpretations of single photon emission computed tomography (SPECT) using a cerebral blood flow and a dopamine transporter tracer in patients with chronic mild traumatic brain injury (TBI). The goal was to determine how these two different scan might be used and compared to each other in this patient population.Methods and FindingsTwenty-five patients with persistent symptoms after a mild TBI underwent SPECT with both 99mTc exametazime to measure cerebral blood flow (CBF) and 123I ioflupane to measure dopamine transporter (DAT) binding. The scans were interpreted by two expert readers blinded to any case information and were assessed for abnormal findings in comparison to 10 controls for each type of scan. Qualitative CBF scores for each cortical and subcortical region along with DAT binding scores for the striatum were compared to each other across subjects and to controls. In addition, symptoms were compared to brain scan findings. TBI patients had an average of 6 brain regions with abnormal perfusion compared to controls who had an average of 2 abnormal regions (p<0.001). Patient with headaches had lower CBF in the right frontal lobe, and higher CBF in the left parietal lobe compared to patients without headaches. Lower CBF in the right temporal lobe correlated with poorer reported physical health. Higher DAT binding was associated with more depressive symptoms and overall poorer reported mental health. There was no clear association between CBF and DAT binding in these patients.ConclusionsOverall, both scans detected abnormalities in brain function, but appear to reflect different types of physiological processes associated with chronic mild TBI symptoms. Both types of scans might have distinct uses in the evaluation of chronic TBI patients depending on the clinical scenario.

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Section: Introductionmentioning

confidence: 99%

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

et al. 2014

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“…Employing alternative medical treatments, such as Holographic Kinetics, as most depression can be cleared in a few sessions, with Holographic Kinetics, this simply could give more options that are desperately needed to treat veterans affected by PTSD, depression and suicidal ideations. Further research is needed to scientifically measure the efficacy and effectiveness of this non invasive holistic mental health modality on a larger scale [47].…”

Section: Resultsmentioning

confidence: 99%

Holographic Kinetics for Clinically Diagnosed Suicidal, Depressed, PTSD Military Veterans: Case Study

Chevalier¹

2017

ACIM

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“…[149][150][151][152][153][154] Standard neuroimaging with computed tomography (CT) or magnetic resonance imaging (MRI) is negative in concussion but are used to evaluate for more serious brain injury. 4,95 Computer tomography is best used acutely for evaluating for bony fracture and for intracranial bleeding, contusion, mass effects, and/or brain stem herniation, whereas MRI is more sensitive for evaluating persistent or worsening symptoms or concern for underlying pathology (eg, headache or seizure disorder, arteriovenous malformation, Chiari malformation, etc).…”

Section: Neuroimagingmentioning

confidence: 99%

American Medical Society for Sports Medicine Position Statement

Harmon

Drezner

Gammons³

et al. 2013

Clinical Journal of Sport Medicine

296

118

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Executive SummaryPurpose of the Statement • To provide an evidence-based, best practices summary to assist physicians with the evaluation and management of sports concussion. • To establish the level of evidence, knowledge gaps, and areas requiring additional research. Symptom ManagementThe appropriate management of concussion symptoms requires careful consideration of the timing and natural history of the injury. In the acute setting (0-10 hours postonset Clin

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Brain SPECT Imaging in Complex Psychiatric Cases: An Evidence-Based, Underutilized Tool

Cited by 47 publications

References 58 publications

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

Clinical Comparison of 99mTc Exametazime and 123I Ioflupane SPECT in Patients with Chronic Mild Traumatic Brain Injury

Holographic Kinetics for Clinically Diagnosed Suicidal, Depressed, PTSD Military Veterans: Case Study

American Medical Society for Sports Medicine Position Statement

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