Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

Tastevin, Maud; Boyer, Laurent; Korchia, Théo; Fond, Guillaume; Lançon, Christophe; Richieri, Raphaëlle; Guedj, Éric

doi:10.1186/s13550-020-00713-2

Cited by 9 publications

(6 citation statements)

References 29 publications

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“…Brain SPECT perfusions and PET metabolism appear to be discordant biomarkers in depressive disorders, as recently reported [ 28 ], with no significant relationship between brain metabolism and chronicity of illness.…”

Section: Discussionsupporting

confidence: 53%

Progressive Unspecified Motor Speech Disorder: A Longitudinal Single Case Study of an Older Subject

et al. 2022

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Introduction: In a few cases, neurodegenerative diseases debut with a speech disorder whose differential diagnosis can be difficult. Case Report: We describe the case of a right-handed woman with a progressive speech impairment, which debuted when she was 80 years old. We report the results of neurological, neuropsychological, and imaging assessments with positron emission tomography (PET) over a period of nine years. Metabolic PET with 18F-FDG was performed at the age of 81 and repeated two years later due to the worsening of symptoms; amyloid PET with 18F-flutemetamol was performed at the age of 86. All PET results were quantitatively analyzed. A speech impairment remained the isolated neurological symptom for a long time, together with a mood disorder. Early FDG-PET showed hypometabolism in the left superior and inferior frontal areas, in the left superior temporal area, and in the right superior frontal area. Two years later, the hypometabolic area was more extensive. Amyloid PET was qualitatively and quantitatively normal. Nine years after the first symptoms, the speech production progressively worsened until complete anarthria, in association with writing impairment onset and signs of behavioral impairments. No signs of motor involvement were found. Conclusions: A progressive articulatory disorder without an evolution of motor disorders may be a distinct neurological degenerative entity, mainly affecting speech production for very a long time and with a specific early metabolic pattern in brain FDG-PET in the language production area. Monitoring patients with FDG-PET could predict the disease evolution years before a clinical deterioration.

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Section: Discussionsupporting

confidence: 53%

Progressive Unspecified Motor Speech Disorder: A Longitudinal Single Case Study of an Older Subject

et al. 2022

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“…As the ACC is considered to have a key role in the pathophysiology of the disorder, lack of normal symmetries in ACC has been long observed. In task-related fMRI, decreased functional connectivity between the left amygdala and the left ACC during negative stimuli in participants with MDD was found ( 41 ), while the increased depression duration was correlated with decreased perfusion of the right ACC ( 42 ). Consistent with the previous findings, our results suggest that lack of normal symmetries may be a characteristic for patients with MDD.…”

Section: Discussionmentioning

confidence: 99%

Abnormal Reginal Homogeneity in Left Anterior Cingulum Cortex and Precentral Gyrus as a Potential Neuroimaging Biomarker for First-Episode Major Depressive Disorder

et al. 2022

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ObjectiveThere is no objective method to diagnose major depressive disorder (MDD). This study explored the neuroimaging biomarkers using the support vector machine (SVM) method for the diagnosis of MDD.Methods52 MDD patients and 45 healthy controls (HCs) were involved in resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Imaging data were analyzed with the regional homogeneity (ReHo) and SVM methods.ResultsCompared with HCs, MDD patients showed increased ReHo in the left anterior cingulum cortex (ACC) and decreased ReHo in the left precentral gyrus (PG). No correlations were detected between the ReHo values and the Hamilton Rating Scale for Depression (HRSD) scores. The SVM results showed a diagnostic accuracy of 98.96% (96/97). Increased ReHo in the left ACC, and decreased ReHo in the left PG were illustrated, along with a sensitivity of 98.07%(51/52) and a specificity of100% (45/45).ConclusionOur results suggest that abnormal regional neural activity in the left ACC and PG may play a key role in the pathophysiological process of first-episode MDD. Moreover, the combination of ReHo values in the left ACC and precentral gyrusmay serve as a neuroimaging biomarker for first-episode MDD.

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“…The metabolic pattern of depression on [ 18 F] FDG PET/CT typically consists of decreased metabolic activity of the right middle frontal cortex, the right anterior cingulum cortex, the right insula, the right medial temporal cortex and the left precuneus. The duration of depression correlates with decreased activity of the right anterior cingulum cortex [32]. Additionally, a study by Tashiro et al [33] reported that the depression pattern in neurological [ 18 F]FDG PET/CT in cancer patients without brain metastasis included hypometabolic areas in limbic structures, such as the anterior and posterior cingulate gyri, the basolateral frontal cortices, as well as in the basal ganglia (especially the caudate nucleus) and frontal cortex.…”

Section: Discussionmentioning

confidence: 99%

Brain metabolic changes in patients with disseminated malignant melanoma under immunotherapy

et al. 2022

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Although there is evidence that chemotherapy can have side effects on metabolism and brain function, there are few studies on the occurrence of these side effects with immunotherapy. The present study was conducted to assess whether brain metabolic changes occur in patients with malignant melanoma under immunotherapy. Thirty-nine patients after surgical intervention and with a diagnosis of malignant melanoma were retrospectively included and were divided into two groups: one group under the first-line therapy with anti-programmed cell death-1 ± anti-cytotoxic T lymphocyte antigen-4 monoclonal antibodies and the other group without any treatment after surgery, which served as a control. Basal and follow-up whole body and brain 2-[ 18 F] fluoro-2-deoxy-D-glucose ( 18 F]FDG) PET/computed tomography (CT) studies were performed. Changes in brain glucose metabolism after treatment initiation of the immunotherapy group were compared with the findings in the control group. In addition, longitudinal regression analysis to investigate whether the time under immunotherapy influenced the changes of brain metabolism was performed. None of the patients presented cognitive impairment or other neurological alterations between basal and follow-up brain [ 18 F]FDG PET/CT examinations. The statistical analysis revealed a significant relative SUV (SUVr)-loss in the left frontal region in patients of the immunotherapy group compared with the control group, with r adjusted = −0.62 and P = 0.008. Severity of SUVr-loss was correlated with duration of treatment. Patients with disseminated malignant melanoma receiving immunotherapy may present a decrease of brain metabolism in the left frontal region, which is related with time-under-treatment, without any clinical evidence of neurological disorder. Melanoma Res

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Brain SPECT perfusion and PET metabolism as discordant biomarkers in major depressive disorder

Cited by 9 publications

References 29 publications

Progressive Unspecified Motor Speech Disorder: A Longitudinal Single Case Study of an Older Subject

Progressive Unspecified Motor Speech Disorder: A Longitudinal Single Case Study of an Older Subject

Abnormal Reginal Homogeneity in Left Anterior Cingulum Cortex and Precentral Gyrus as a Potential Neuroimaging Biomarker for First-Episode Major Depressive Disorder

Brain metabolic changes in patients with disseminated malignant melanoma under immunotherapy

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