Brain stimulation during an afternoon nap boosts slow oscillatory activity and memory consolidation in older adults

Ladenbauer, Julia; Külzow, Nadine; Paßmann, Sven; Antonenko, Daria; Grittner, Ulrike; Tamm, Sascha; Flöel, Agnes

doi:10.1016/j.neuroimage.2016.06.057

Cited by 85 publications

(101 citation statements)

References 88 publications

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“…61 The current evidence compels the conclusion that sleep intervals will not always benefit episodic memory consolidation in older adults, even when using methods that aim to minimize age deficits at encoding and retrieval. Largescale interventional trials (eg, pharmacologic, behavioral, deep brain stimulation [62][63][64][65] ) that manipulate various aspects of sleep in older adults, and include a diversity of cognitive outcomes, will be required to conclude with certainty whether sleep does (or does not) benefit specific cognitive functions.…”

Section: Discussionmentioning

confidence: 99%

The Effects of an Afternoon Nap on Episodic Memory in Young and Older Adults

Scullin

Fairley

Decker

et al. 2017

Sleep

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Study Objectives: In young adults, napping is hypothesized to benefit episodic memory retention (eg, via consolidation). Whether this relationship is present in older adults has not been adequately tested but is an important question because older adults display marked changes in sleep and memory. Design: Between-subjects design. Setting: Sleep laboratory at Emory University School of Medicine. Participants: Fifty healthy young adults (18-29) and 45 community-dwelling older adults (58-83). Intervention: Participants were randomly assigned to a 90-minute nap opportunity or an equal interval of quiet wakefulness. Measurements and Results: Participants underwent an item-wise directed forgetting learning procedure in which they studied words that were individually followed by the instruction to "remember" or "forget." Following a 90-minute retention interval filled with quiet wakefulness or a nap opportunity, they were asked to free recall and recognize those words. Young adults retained significantly more words following a nap interval than a quiet wakefulness interval on both free recall and recognition tests. There was modest evidence for greater nap-related retention of "remember" items relative to "forget" items for free recall but not recognition. Older adults' memory retention did not differ across nap and quiet wakefulness conditions, although they demonstrated greater fragmentation, lower N3, and lower rapid eye movement duration than the young adults. Conclusions: In young adults, an afternoon nap benefits episodic memory retention, but such benefits decrease with advancing age.

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Section: Discussionmentioning

confidence: 99%

The Effects of an Afternoon Nap on Episodic Memory in Young and Older Adults

Scullin

Fairley

Decker

et al. 2017

Sleep

View full text Add to dashboard Cite

show abstract

“…In older adults, multiple studies have shown that enhancing the slow oscillation using tDCS during an afternoon nap leads to a memory enhancement; one showing heightened SWA in the slow oscillation frequency range (<1 Hz) and word-pair performance (Westerberg et al, 2015), and another showing enhanced slow oscillation and fast sleep spindle EEG power that led to a benefit in a visual memory task (Ladenbauer et al, 2016). Auditory closed-loop stimulation during slow wave sleep has also been shown to enhance slow oscillation power and associated hippocampus-dependent memory consolidation in young adults (Ngo et al, 2013).…”

Section: Are There Functional Consequences Of Age-related Sleep Impaimentioning

confidence: 99%

Sleep and Human Aging

Mander

Winer

Walker

2017

Neuron

851

619

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Older adults do not sleep as well as younger adults. Why? What alterations in sleep quantity and quality occur as we age, and are there functional consequences? What are the underlying neural mechanisms that explain age-related sleep disruption? This review tackles these questions. First, we describe canonical changes in human sleep quantity and quality in cognitively normal older adults. Second, we explore the underlying neurobiological mechanisms that may account for these human sleep alterations. Third, we consider the functional consequences of age-related sleep disruption, focusing on memory impairment as an exemplar. We conclude with a discussion of a still-debated question: do older adults simply need less sleep, or rather, are they unable to generate the sleep that they still need?

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“…otDCS also improved declarative memory performance after sleep, demonstrating a causal role of slow oscillations in declarative memory consolidation. More recently, Ladenbauer and colleagues [94] found that otDCS enhanced slow oscillatory activity as well as fast spindle activity in older participants when applied during an afternoon nap. Moreover, otDCS improved picture memory retention after sleep.…”

Section: An Introduction To Noninvasive Brain Stimulationmentioning

confidence: 99%

Adaptive Plasticity in the Healthy Language Network: Implications for Language Recovery after Stroke

Hartwigsen

2016

Neural Plasticity

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Across the last three decades, the application of noninvasive brain stimulation (NIBS) has substantially increased the current knowledge of the brain's potential to undergo rapid short-term reorganization on the systems level. A large number of studies applied transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) in the healthy brain to probe the functional relevance and interaction of specific areas for different cognitive processes. NIBS is also increasingly being used to induce adaptive plasticity in motor and cognitive networks and shape cognitive functions. Recently, NIBS has been combined with electrophysiological techniques to modulate neural oscillations of specific cortical networks. In this review, we will discuss recent advances in the use of NIBS to modulate neural activity and effective connectivity in the healthy language network, with a special focus on the combination of NIBS and neuroimaging or electrophysiological approaches. Moreover, we outline how these results can be transferred to the lesioned brain to unravel the dynamics of reorganization processes in poststroke aphasia. We conclude with a critical discussion on the potential of NIBS to facilitate language recovery after stroke and propose a phase-specific model for the application of NIBS in language rehabilitation.

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Brain stimulation during an afternoon nap boosts slow oscillatory activity and memory consolidation in older adults

Cited by 85 publications

References 88 publications

The Effects of an Afternoon Nap on Episodic Memory in Young and Older Adults

The Effects of an Afternoon Nap on Episodic Memory in Young and Older Adults

Sleep and Human Aging

Adaptive Plasticity in the Healthy Language Network: Implications for Language Recovery after Stroke

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