Brain stimulation-on-a-chip: a neuromodulation platform for brain slices

Shaner, Sebastian; Lu, Han; Lenz, Maximilian; Garg, Shreyash; Vlachos, Andreas; Asplund, Maria

doi:10.1039/d3lc00492a

Lab Chip

2023

DOI: 10.1039/d3lc00492a

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Brain stimulation-on-a-chip: a neuromodulation platform for brain slices

Sebastian Shaner,

Han Lu,

Maximilian Lenz

et al.

Abstract: We developed a microfluidic platform for precise electrical stimulation on brain tissue slices. It overcomes conventional electric dosage and electrochemical concerns by utilizing precise fluidic, electrochemical, and magnetic control.

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Cited by 4 publications

References 80 publications

(123 reference statements)

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Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Kale,

Wankhede,

Bishoyi

et al. 2025

Neuroscience

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Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Kale,

Wankhede,

Bishoyi

et al. 2025

Neuroscience

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Unveiling the Human Brain on a Chip: An Odyssey to Reconstitute Neuronal Ensembles and Explore Plausible Applications in Neuroscience

Nandi,

Ghosh,

Garg

et al. 2024

ACS Chem. Neurosci.

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The brain is an incredibly complex structure that consists of millions of neural networks. In developmental and cellular neuroscience, probing the highly complex dynamics of the brain remains a challenge. Furthermore, deciphering how several cues can influence neuronal growth and its interactions with different brain cell types (such as astrocytes and microglia) is also a formidable task. Traditional in vitro macroscopic cell culture techniques offer simple and straightforward methods. However, they often fall short of providing insights into the complex phenomena of neuronal network formation and the relevant microenvironments. To circumvent the drawbacks of conventional cell culture methods, recent advancements in the development of microfluidic device-based microplatforms have emerged as promising alternatives. Microfluidic devices enable precise spatiotemporal control over compartmentalized cell cultures. This feature facilitates researchers in reconstituting the intricacies of the neuronal cytoarchitecture within a regulated environment. Therefore, in this review, we focus primarily on modeling neuronal development in a microfluidic device and the various strategies that researchers have adopted to mimic neurogenesis on a chip. Additionally, we have presented an overview of the application of brain-on-chip models for the recapitulation of the blood-brain barrier and neurodegenerative diseases, followed by subsequent highthroughput drug screening. These lab-on-a-chip technologies have tremendous potential to mimic the brain on a chip, providing valuable insights into fundamental brain processes. The brain-on-chip models will also serve as innovative platforms for developing novel neurotherapeutics to address several neurological disorders.

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Bioelectronics for electrical stimulation: materials, devices and biomedical applications

Huang,

Yao,

Zhang

et al. 2024

Chem. Soc. Rev.

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Brain stimulation-on-a-chip: a neuromodulation platform for brain slices

Abstract: We developed a microfluidic platform for precise electrical stimulation on brain tissue slices. It overcomes conventional electric dosage and electrochemical concerns by utilizing precise fluidic, electrochemical, and magnetic control.

Cited by 4 publications

References 80 publications

Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Emerging biophysical techniques for probing synaptic transmission in neurodegenerative disorders

Unveiling the Human Brain on a Chip: An Odyssey to Reconstitute Neuronal Ensembles and Explore Plausible Applications in Neuroscience

Bioelectronics for electrical stimulation: materials, devices and biomedical applications

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