Brain stimulation studies of non-motor cerebellar function: A systematic review

Tomlinson, Simon P.; Davis, Nick J.; Bracewell, R. Martyn

doi:10.1016/j.neubiorev.2013.03.001

Cited by 58 publications

(34 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Schmahmann’s cerebellar cognitive affective syndrome has shown that human cerebellar lesions cause cognitive impairments (Schmahmann, 2004). Inducing transient impairments using repetitive transcranial cerebellar stimulation has recently been shown to impair cognitive tasks such as language, emotion, learning, memory, perception, and timing (Fierro et al, 2007; Koch et al, 2007; Oliveri et al, 2007; Grube et al, 2010; Bijsterbosch et al, 2011; Boehringer et al, 2013; Tomlinson et al, 2013; Grimaldi et al, 2014). Similar deficits are reported following lesions to the anterior cingulate (Devinsky et al, 1995).…”

Section: Cingulocerebellar Interactions In Schizophreniamentioning

confidence: 99%

The therapeutic potential of the cerebellum in schizophrenia

Parker

Narayanan

Andreasen

2014

Front. Syst. Neurosci.

View full text Add to dashboard Cite

The cognitive role of the cerebellum is critically tied to its distributed connections throughout the brain. Accumulating evidence from anatomical, structural and functional imaging, and lesion studies advocate a cognitive network involving indirect connections between the cerebellum and non-motor areas in the prefrontal cortex. Cerebellar stimulation dynamically influences activity in several regions of the frontal cortex and effectively improves cognition in schizophrenia. In this manuscript, we summarize current literature on the cingulocerebellar circuit and we introduce a method to interrogate this circuit combining opotogenetics, neuropharmacology, and electrophysiology in awake-behaving animals while minimizing incidental stimulation of neighboring cerebellar nuclei. We propose the novel hypothesis that optogenetic cerebellar stimulation can restore aberrant frontal activity and rescue impaired cognition in schizophrenia. We focus on how a known cognitive region in the frontal cortex, the anterior cingulate, is influenced by the cerebellum. This circuit is of particular interest because it has been confirmed using tracing studies, neuroimaging reveals its role in cognitive tasks, it is conserved from rodents to humans, and diseases such as schizophrenia and autism appear in its aberrancy. Novel tract tracing results presented here provide support for how these two areas communicate. The primary pathway involves a disynaptic connection between the cerebellar dentate nuclei (DN) and the anterior cingulate cortex. Secondarily, the pathway from cerebellar fastigial nuclei (FN) to the ventral tegmental area, which supplies dopamine to the prefrontal cortex, may play a role as schizophrenia characteristically involves dopamine deficiencies. We hope that the hypothesis described here will inspire new therapeutic strategies targeting currently untreatable cognitive impairments in schizophrenia.

show abstract

Section: Cingulocerebellar Interactions In Schizophreniamentioning

confidence: 99%

The therapeutic potential of the cerebellum in schizophrenia

Parker

Narayanan

Andreasen

2014

Front. Syst. Neurosci.

View full text Add to dashboard Cite

show abstract

“…The cerebellum has traditionally been considered as a key structure in motor behavior and learning [3]. Furthermore, in the last 30 years, converging evidence has indicated the involvement of cerebellum in higher-order cognitive functions and distinct cognitive functions were topographically associated to discrete cerebellar regions [3].…”

mentioning

confidence: 99%

“…Furthermore, in the last 30 years, converging evidence has indicated the involvement of cerebellum in higher-order cognitive functions and distinct cognitive functions were topographically associated to discrete cerebellar regions [3]. Since early neuropsychological studies of patients with cerebellar lesions, disinhibited behavior and deficits in motor cognition were indicated as characteristic signs of cerebellar cognitive affective syndrome [4].…”

mentioning

confidence: 99%

Is Motor Inhibition Mediated by Cerebello-cortical Interactions?

Picazio

Koch

2014

Cerebellum

View full text Add to dashboard Cite

Motor inhibition is an essential skill for fully adapted behavior requiring motor control and higher-order functions of motor cognition. A wide set of cortical and subcortical areas, including the right inferior frontal gyrus, the pre-supplementary motor area, and the subthalamic nucleus in the basal ganglia, contribute to convey the inhibitory command to the motor cortex. In the present review, we discuss how recent evidence supports the idea that the cerebellum may also have a relevant contribution in certain aspects of motor inhibition. This evidence were provided by behavioral data collected in patients with cerebellar lesions, functional magnetic resonance (fMRI) investigations conducted in clinical samples and in healthy participants, and by transcranial magnetic stimulation (TMS) techniques used to non-invasively test cerebello-motor functional connectivity. The application of these methods, combined with the execution of inhibitory tasks, could provide new evidence for a causal role of the effective cerebello-cortical connectivity in motor inhibition. Understanding the neurophysiological mechanisms that mediate motor inhibition through the cerebellum could be essential to design new rehabilitative protocols for treating several neurological and psychiatric disorders characterized by disinhibited behavior such as addiction, schizophrenia, attention deficit hyperactivity disorder (ADHD) and Parkinson's disease.

show abstract

“…However anatomical, physiological and functional neuroimaging studies have revealed the role of cerebellum in non-motor or higher-order function (42,57). Cerebellum has connection with non-motor cortical area related to cognitive and emotional processing (58).…”

Section: The Cerebellar Cognitive Affective Syndromementioning

confidence: 99%