Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review

Kong, Qiao; Li, Tingting; Reddy, Sveta; Hodges, Sierra; Kong, Jian

doi:10.1016/j.neurot.2023.10.007

Cited by 8 publications

(2 citation statements)

References 193 publications

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“…Specifically, the PTH group showed increased perfusion-based FC between the dAI and Rol in this study. The ROL, as an essential brain region of the CON, is mainly involved in task initiation, monitoring and maintenance processes and has a role in complex functions, mainly movement, autonomy, sensation, and emotional and cognitive processing [ 33 , 34 ]. A meta-analysis of voxel-based morphometric (VBM) studies reported that migraine patients showed grey matter abnormalities in the left insula and the bilateral ROL [ 33 ] [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Li,

Zhang,

Ren

et al. 2024

J Headache Pain

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Objective The insula is an important part of the posttraumatic headache (PTH) attributed to mild traumatic brain injury (mTBI) neuropathological activity pattern. It is composed of functionally different subdivisions and each of which plays different role in PTH neuropathology. Methods Ninety-four mTBI patients were included in this study. Based on perfusion imaging data obtained from arterial spin labelling (ASL) perfusion magnetic resonance imaging (MRI), this study evaluated the insular subregion perfusion-based functional connectivity (FC) and its correlation with clinical characteristic parameters in patients with PTH after mTBI and non-headache mTBI patients. Results The insular subregions of mTBI + PTH (mTBI patients with PTH) and mTBI-PTH (mTBI patients without PTH) group had positive perfusion-based functional connections with other insular nuclei and adjacent discrete cortical regions. Compared with mTBI-PTH group, significantly increased resting-state perfusion-based FC between the anterior insula (AI) and middle cingulate cortex (MCC)/Rolandic operculum (ROL), between posterior insula (PI) and supplementary motor area (SMA), and decreased perfusion-based FC between PI and thalamus were found in mTBI + PTH group. Changes in the perfusion-based FC of the left posterior insula/dorsal anterior insula with the thalamus/MCC were significant correlated with headache characteristics. Conclusions Our findings provide new ASL-based evidence for changes in the perfusion-based FC of the insular subregion in PTH patients attributed to mTBI and the association with headache features, revealing the possibility of potential neuroplasticity after PTH. These findings may contribute to early diagnosis of the disease and follow-up of disease progression.

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Section: Discussionmentioning

confidence: 99%

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Li,

Zhang,

Ren

et al. 2024

J Headache Pain

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“…These techniques can modulate neuroplasticity by inducing changes in cortical excitability and connectivity, offering potential avenues for ameliorating symptoms associated with conditions such as depression, schizophrenia (SCZ), and chronic pain [ 24 , 25 , 26 ]. Research indicates that NIBS holds promise for enhancing cognitive function, alleviating mood disturbances, and reducing pain perception by targeting specific brain regions implicated in these processes [ 27 , 28 , 29 ]. Moreover, combining NIBS with cognitive training, psychotherapy, or pharmacotherapy may enhance treatment outcomes synergistically [ 30 , 31 , 32 , 33 ].…”

Section: Introductionmentioning

confidence: 99%

From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders

Tanaka,

Vécsei

2024

Biomedicines

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Role of Exercise on Neuropathic Pain in Preclinical Models: Perspectives for Neuroglia

Zhu,

Zheng,

Gong

et al. 2024

Mol Neurobiol

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Brain stimulation targets for chronic pain: Insights from meta-analysis, functional connectivity and literature review

Cited by 8 publications

References 193 publications

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

Connectivity of the insular subdivisions differentiates posttraumatic headache-associated from nonheadache-associated mild traumatic brain injury: an arterial spin labelling study

From Lab to Life: Exploring Cutting-Edge Models for Neurological and Psychiatric Disorders

Role of Exercise on Neuropathic Pain in Preclinical Models: Perspectives for Neuroglia

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