Brain stimulation therapies for neuropsychiatric disease

Holtzheimer, Paul E.; Kosel, Markus; Schläepfer, Thomas E.

doi:10.1016/b978-0-444-52002-9.00041-3

Cited by 19 publications

(9 citation statements)

References 164 publications

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“…Deep-brain stimulation of the subgenual cortex in the treatment of refractory depression, and rapid transcranial stimulation (depression and schizophrenia) recruit clusters of neurones distributed across the frontal cortex (Block and Nemeroff, 2014;Fox et al, 2012;Martin and Martin-Sanchez, 2012;Patel et al, 2010;Schlaepfer and Berwenick, 2013;Schlapfer et al, 2013). Nonetheless, these and related approaches are procedure-dependent, hard to standardize and their applicability and reproducibility are still under scrutiny, so they are unlikely at any time soon to assume a universal role in the control of psychiatric disorders (Block and Nemeroff, 2014;Holtzheimer et al, 2012;Martin and Martin-Sanchez, 2012). Cognitive or brain training has been suggested to enhance the plasticity of neural circuits and synapses (May, 2011;Rabipour and Raz, 2012).…”

Section: Non-pharmacotherapeutic Treatments Alone and In Associationmentioning

confidence: 98%

Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders

Millan¹,

Goodwin²,

Meyer‐Lindenberg³

et al. 2015

European Neuropsychopharmacology

114

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Section: Non-pharmacotherapeutic Treatments Alone and In Associationmentioning

confidence: 98%

Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders

Millan¹,

Goodwin²,

Meyer‐Lindenberg³

et al. 2015

European Neuropsychopharmacology

114

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“…This might reflect a culture in which we conceptualize our minds and bodies as machines whose dysfunctions can be fixed or substituted with technology-in most cases even without knowing about the mechanisms that are causing the symptoms. In spite of these dreams, a variety of available treatment options and novel avenues of interventions in research (Holtzheimer et al, 2012a;Schlaepfer et al, 2010), a third of patients suffering from depression can be classified as treatment-resistant (Rush et al, 2006), with very little hope of recovery, highly stigmatized and unbearably low QoL. For these patients, deep brain stimulation (DBS) is currently under investigation.…”

Section: Introductionmentioning

confidence: 99%

Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook

Schläepfer

Bewernick

Kayser

et al. 2014

Neuropsychopharmacol

149

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Deep brain stimulation (DBS) as a putative approach for treatment-resistant depression (TRD) has now been researched for about a decade. Several uncontrolled studies--all in relatively small patient populations and different target regions-have shown clinically relevant antidepressant effects in about half of the patients and very recently, DBS to a key structure of the reward system, the medial forebrain bundle, has yielded promising results within few days of stimulation and at much lower stimulation intensities. On the downside, DBS procedures in regions are associated with surgical risks (eg, hemorrhage) and psychiatric complications (suicidal attenuation, hypomania) as well as high costs. This overview summarizes research on the mechanisms of brain networks with respect to psychiatric diseases and--as a novelty--extrapolates to the role of the reward system in DBS for patients with treatment-resistant depression. It further evaluates relevant methodological aspects of today's research in DBS for TRD. On the scientific side, the reward system has an important yet clearly under-recognized role in both neurobiology and treatment of depression. On the methodological side of DBS research in TRD, better animal models are clearly needed to explain clinical effects of DBS in TRD. Larger sample sizes, long-term follow-up and designs including blinded sham control are required to draw final conclusions on efficacy and side effects. Practical research issues cover study design, patient tracking, and the discussion of meaningful secondary outcome measures.

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“…TMS is not only used to determine the causative role of cortical areas in various cognitive domains, but is also applied as a treatment in a wide variety of neurologic and neuropsychiatric disorders (Croarkin et al, 2011; Holtzheimer et al, 2012; Peng et al, 2012). However, due to the high costs of TMS and because of safety risks when enhancing cortical regions (Hummel and Cohen, 2006; Cohen Kadosh et al, 2012), a related method, namely transcranial Direct Current Stimulation (tDCS) has been increasingly used in recent years both in basic research and for treatment.…”

Section: Introductionmentioning

confidence: 99%

Enhancing performance in numerical magnitude processing and mental arithmetic using transcranial Direct Current Stimulation (tDCS)

Hauser

Rotzer

Grabner

et al. 2013

Front. Hum. Neurosci.

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The ability to accurately process numerical magnitudes and solve mental arithmetic is of highest importance for schooling and professional career. Although impairments in these domains in disorders such as developmental dyscalculia (DD) are highly detrimental, remediation is still sparse. In recent years, transcranial brain stimulation methods such as transcranial Direct Current Stimulation (tDCS) have been suggested as a treatment for various neurologic and neuropsychiatric disorders. The posterior parietal cortex (PPC) is known to be crucially involved in numerical magnitude processing and mental arithmetic. In this study, we evaluated whether tDCS has a beneficial effect on numerical magnitude processing and mental arithmetic. Due to the unclear lateralization, we stimulated the left, right as well as both hemispheres simultaneously in two experiments. We found that left anodal tDCS significantly enhanced performance in a number comparison and a subtraction task, while bilateral and right anodal tDCS did not induce any improvements compared to sham. Our findings demonstrate that the left PPC is causally involved in numerical magnitude processing and mental arithmetic. Furthermore, we show that these cognitive functions can be enhanced by means of tDCS. These findings encourage to further investigate the beneficial effect of tDCS in the domain of mathematics in healthy and impaired humans.

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Brain stimulation therapies for neuropsychiatric disease

Cited by 19 publications

References 164 publications

Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders

Learning from the past and looking to the future: Emerging perspectives for improving the treatment of psychiatric disorders

Deep Brain Stimulation of the Human Reward System for Major Depression—Rationale, Outcomes and Outlook

Enhancing performance in numerical magnitude processing and mental arithmetic using transcranial Direct Current Stimulation (tDCS)

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