Brain Structural and Functional Alterations Specific to Low Sleep Efficiency in Major Depressive Disorder

Yang, Ying; Zhu, Daomin; Zhang, Cun; Zhang, Yu; Wang, Chunli; Zhang, Biao; Zhao, Wenming; Zhu, Jiajia; Yu, Yongqiang

doi:10.3389/fnins.2020.00050

Cited by 36 publications

(28 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We also used an ISI scale score cut-off of seven for expressing sleep impairment in a clinically applicable way and for quantifying its risks associated with health status and disease severity. The observed distribution of insomnia was summarized in defined groups based on the scores from the ISI as follows: none (0-7), mild (8)(9)(10)(11)(12)(13)(14), moderate (15)(16)(17)(18)(19)(20)(21), and severe (22-28). 13 Depression was rated in PHQ-9 at five levels: none (0-4), mild (5-9), moderate (10-14), moderate-severe (15-19, and severe (20)(21)(22)(23)(24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

“…The observed distribution of insomnia was summarized in defined groups based on the scores from the ISI as follows: none (0-7), mild (8)(9)(10)(11)(12)(13)(14), moderate (15)(16)(17)(18)(19)(20)(21), and severe (22-28). 13 Depression was rated in PHQ-9 at five levels: none (0-4), mild (5-9), moderate (10-14), moderate-severe (15-19, and severe (20)(21)(22)(23)(24)(25)(26)(27). Anxiety was graded according to the score of the GAD-7: none (0-4), mild (5-9), moderate (10-13), moderate-severe (14)(15)(16)(17)(18), and severe (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Association of Insomnia with Depression and Anxiety Symptoms in Patients Undergoing Noncardiac Surgery

Huang¹,

Wu²,

Wu³

et al. 2021

NDT

View full text Add to dashboard Cite

Objective Insomnia is common in patients undergoing surgery. It can increase the rate of postoperative complications, interfere with patient recovery, and decrease hospital satisfaction. However, there are few studies on perioperative insomnia. This study was conducted to investigate the differences in the demographic, health status, and clinical characteristics of patients with and without insomnia postoperatively, and to identify the potential risk factors of insomnia. Methods There were 299 non-cardiac surgery patients, 165 females, and 134 males, with a mean age of 55 years, enrolled in the study. The Insomnia Severity Index (ISI), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder 7 (GAD-7), and Montreal Cognitive Assessment (MoCA) were administered to all the patients preoperatively. The Visual Analogue Scale (VAS) was used preoperatively, and at the end of the surgery, and then one day, two days, and three days after surgery. The PHQ-9, the GAD-7, and the ISI were repeated three days after surgery. Insomnia was diagnosed by the ISI as being a score of 8–28 (mild: 8–14; moderate-severe: 15–21; severe: 22–28). The patients were divided into group A (with insomnia, N=78) and group B (without insomnia, N=221) according to their ISI score three days after surgery. The general clinical data of the two groups were analyzed first, and then binary logistic regression analysis was conducted to assess the risk factors of insomnia. Results A total of 299 non-cardiac surgery patients with a mean age of 55 years were enrolled in the study. Of the included patients, the number of females was 165 and the number of the male was 134. The incidence of insomnia at 3 days postoperatively was 26.1% (78/299). The average points that group A patients scored in the ISI, PHQ-9, and the GAD-7 were significantly higher than those in group B. The VAS score three days after surgery was significantly higher in group A. The PHQ-9 and the GAD-7 three days after surgery showed significantly higher depression and anxiety scores in group A. Logistic regression showed that the ISI ( p <0.001, 95% CI=1.218–1.500) and the GAD-7 ( p =0.003, 95% CI=1.041–1.218) preoperatively, and the PHQ-9 postoperatively ( p <0.001, 95% CI=1.226–1.555), were risk factors of insomnia. Conclusion Insomnia is common and can worsen after surgery. The present study suggests that depression and anxiety are risk factors for insomnia after surgery. There is a need for further research and the development of strategies for depression and anxiety management to ensure better sleep quality for patients, which will be of significant benefit to their health. Clinical Trial Registration The study was registered at clinical trial (NCT04027751); Trial registration: clinical trial, NCT04027751. Registered 22 July 2019; https://clinical...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Association of Insomnia with Depression and Anxiety Symptoms in Patients Undergoing Noncardiac Surgery

Huang¹,

Wu²,

Wu³

et al. 2021

NDT

View full text Add to dashboard Cite

show abstract

“…The observed distributions in the insomnia were summarized in de ned groups based on the scores from ISI as follows: none (0-7), mild (8)(9)(10)(11)(12)(13)(14), moderate (15)(16)(17)(18)(19)(20)(21), severe (22)(23)(24)(25)(26)(27)(28). Depression was rate on PHQ-9 of ve levels: none (0-4), mild (5-9), moderate (10)(11)(12)(13)(14), moderatesevere (15)(16)(17)(18)(19) severe (20)(21)(22)(23)(24)(25)(26)(27). Anxiety was graded according to the score of the GAD-7: none (0-4), mild (5-9), moderate (10-13), moderate-severe (14-18), severe (19)(20)(21).…”

Section: Discussionmentioning

confidence: 99%

“…Depression and anxiety in elderly Asian participates are associated with several sleep disorders by somewhat different pro le [16]. Although the relationship between insomnia and depression has been studied extensively [17], little is known about the association between sleep quality and depression or between insomnia and anxiety in surgical patients.…”

Section: Discussionmentioning

confidence: 99%

Insomnia is Associated with Depression and Anxiety in Patients Undergoing Noncardiac Surgery

Huang

Chen

Wang

et al. 2020

Preprint

View full text Add to dashboard Cite

BackgroundTo investigate the difference of demographic, health status and clinical characteristics of patients with or without insomnia postoperatively, and to identify the potential risk factors of insomnia.Methods299 patients undergoing surgery were included. Patients were divided into group A (insomnia, N = 78) and group B (without insomnia, N = 221). Insomnia Severity Index (ISI), Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder (GAD-7), and Montreal cognitive assessment (MoCA) were applied to all patients preoperatively. Visual Analogue Scale (VAS) was assessed preoperatively, and at the end of the surgery, one day after surgery, two days after surgery and three days after surgery. The PHQ-9, the GAD-7 and the ISI were reassessed three days after surgery. Information on sociodemographic variables and demographic data were collected.ResultsAmong the two groups, the average points patients got in the ISI, PHQ-9 and the GAD-7 in group A were also significantly higher than those in group B. The VAS score 3 days after surgery was significantly higher in group A. The PHQ-9 and the GAD-7 3 days after surgery showed significantly higher depression and anxiety scores in group A. Logistic regression showed ISI (P < 0.001, 95%CI = 1.218-1.500), the GAD-7 (P = 0.01, 95%CI = 0.712–0.954) preoperatively and the PHQ-9 postoperatively (P < 0.001, 95%CI = 1.226–1.555) were risk factors of insomnia.ConclusionsInsomnia is common in patients, which worsen after surgery. The present study suggests that depression and anxiety are risk factors of poor sleep quality after surgery. There is a need for further research and strategies for depression and anxiety management to achieve better sleep and significant health benefits in these patients.Trial registration: clinical trial, NCT04027751. Registered 22 July 2019, https://clinicaltrials.gov/ct2/show/NCT04027751?cond=NCT04027751&cntry=CN&draw=2&rank=1.

show abstract

“…Structural MRI, arterial spin labeling (ASL), resting-state functional MRI (fMRI), and diffusion tensor imaging (DTI) were adopted to assess brain structure, perfusion, and function. Mounting evidence converges to support the concept that a conjoint analysis of multimodal imaging data would provide integrated information on complex underlying neurobiological features [24][25][26]. Additionally, the Go/No-Go task was employed to assess the ability of behavioral inhibition [27].…”

Section: Introductionmentioning

confidence: 99%

Sex-dependent Gut Microbiota-brain-cognition Associations: A Multimodal MRI Study

Zhang

Cai

Wang

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

Background: There is bidirectional communication between the gut microbiota and the brain. Empirical evidence has demonstrated sex differences in both the gut microbiome and the brain. However, the effects of sex on the gut microbiota-brain associations have yet to be determined. Methods: 157 healthy young adults underwent brain structural, perfusion, functional and diffusion MRIs to measure gray matter volume (GMV), cerebral blood flow (CBF), functional connectivity strength (FCS) and white matter integrity, respectively. Fecal samples were collected and 16S rRNA gene amplicon sequencing was utilized to assess gut microbial diversity. Correlation analyses were conducted to test for sex-dependent associations between microbial diversity and brain imaging parameters, and mediation analysis was performed to further characterize the gut microbiota-brain-cognition relationship. Results: We found that higher gut microbial diversity was associated with higher GMV in the right cerebellum Ⅵ, higher CBF in the bilateral calcarine sulcus yet lower CBF in the left superior frontal gyrus, higher FCS in the bilateral paracentral lobule, and lower diffusivity in widespread white matter regions in males. However, these associations were absent in females. Of more importance, these neuroimaging biomarkers significantly mediated the association between gut microbial diversity and behavioral inhibition in males. Conclusions: These findings highlight sex as a potential influential factor underlying the gut microbiota-brain-cognition relationship, and expose the gut microbiota as a biomarker-driven and sex-sensitive intervention target for mental disorders with abnormal behavioral inhibition.

show abstract

Brain Structural and Functional Alterations Specific to Low Sleep Efficiency in Major Depressive Disorder

Cited by 36 publications

References 63 publications

The Association of Insomnia with Depression and Anxiety Symptoms in Patients Undergoing Noncardiac Surgery

The Association of Insomnia with Depression and Anxiety Symptoms in Patients Undergoing Noncardiac Surgery

Insomnia is Associated with Depression and Anxiety in Patients Undergoing Noncardiac Surgery

Sex-dependent Gut Microbiota-brain-cognition Associations: A Multimodal MRI Study

Contact Info

Product

Resources

About