Brain structural and functional changes in patients with major depressive disorder: a literature review

Dai, Lisong; Zhou, Hongmei; Xu, Xiangyang; Zuo, Zhentao

doi:10.7717/peerj.8170

Cited by 79 publications

(57 citation statements)

References 81 publications

(85 reference statements)

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“…Olfactory identification involved cognitive processes [13] that may be altered in depression. Studies show that depressed patients exhibit abnormal reactivity of the amygdala and a decreased response to positive stimuli thus explaining deficit in the olfactory identification of pleasant smells [72,73].…”

Section: Neuroimaging In Depression and Olfactionmentioning

confidence: 99%

Olfactory markers for depression: Differences between bipolar and unipolar patients

Kazour

Richa

Char³

et al. 2020

PLoS ONE

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The aim of the study was to compare olfactory functions between unipolar and bipolar patients according to the thymic states (depressed, euthymic) and determine specific olfactory variations between these different states. Methods We recruited 176 participants in 5 groups: depressed bipolar (DB), euthymic bipolar (EB), depressed unipolar (DU), euthymic unipolar (EU), and controls (HC). They were assessed using the Sniffin' sticks threshold and identification tests. Odors' pleasantness, intensity, familiarity and emotion were assessed. Clinical evaluation explored dimensions of depression, mania, anxiety, and anhedonia. Results Smell identification was lower in DU compared to EU patients and controls. Pleasant odors received lower hedonic rating in DU and DB patients compared to EU and EB patients respectively. Negative correlation was found in EB patients between hedonic rating and social anhedonia. In EU patients hedonic rating was negatively correlated with anxietystate, and anhedonia. Conclusions Odor identification of pleasant odors is altered in both depressive states. Only unipolar patients would recover a regular identification level in symptomatic remission, while bipolar subjects would keep their deficits. Hedonic rating is lower in bipolar depressed patients compared to unipolar ones, and these deficits improve after remission. Hedonic rating of pleasant odors may distinguish bipolar depression from unipolar depression during periods of decompensation and phases of remission. Olfactory assessment may be useful to screen unipolar and bipolar depression, leading to possible future sensory markers in mood disorders.

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Section: Neuroimaging In Depression and Olfactionmentioning

confidence: 99%

Olfactory markers for depression: Differences between bipolar and unipolar patients

Kazour

Richa

Char³

et al. 2020

PLoS ONE

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“…But chronic pain conditions produce the hypodopaminergic state, 35 and it would be useful to evaluate FC alterations during the ictal period among chronic migraineurs in the future. Another speculation of this connectivity measures could be based on presence of comorbid depression in patients because of similar network interruptions in patients with major depression 41 and represent the centralization of pain—the process by which the initial pain transforms to chronic pain with complex comorbid changes including altered psychological status, addiction, altered reward, and anti‐reward function 42 . Correlation of increased FC within DMN and HADS depression scores confirm the suggestion that comorbid depression in patients with migraine plays an important role in pain‐reward interactions and could be considered as chronification booster 43 (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Alterations in internetwork functional connectivity in patients with chronic migraine within the boundaries of the Triple Network Model

Trufanov

Markin

Frunza

et al. 2020

Neurology & Clinical Neurosc

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Background Alterations in large‐scale functional connectivity have widely been used to understand migraine pathophysiology and to find any imaging markers. The successful use of the Triple Network Model for many mental and neurological diseases has prompted us to consider chronic migraine under the prism of this model for the first time in the literature. Aim To evaluate alterations in functional connectivity between large‐scale networks using resting‐state fMRI in chronic migraine patients and their correlation with clinical features within the boundaries of the Triple Network Model. Methods Twenty‐five chronic migraine patients underwent 1,5T resting‐state functional magnetic resonance imaging (RS‐fMRI) scanning during the interictal phase and were compared to a group of 25 healthy controls. Functional connectivity was assessed using region‐of‐interest to region‐of‐interest (ROI‐to‐ROI) analysis between 8 networks and 15 subcortical areas, conventionally assigned to salience network. Results Compare to healthy controls, patients had increased functional connectivity between salience network (SN) and sensorimotor network (SMN) and dorsal attention network (DAN), between nucleus accumbens and default mode network (DMN) and within DMN and also between thalamus and DAN. Decreased functional connectivity was registered between nucleus accumbens and DAN, and also within DAN. A higher depression scale score was positively correlated with an increase in FC within DMN. Conclusion Taken together, our results show that patients with chronic migraine could be characterized by specific dysfunctional interactions between the SN, SMN, DAN, and DMN during resting state.

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“…Decreased FC from the amygdala to the hippocampus was observed in patients with depression and individuals at high risk of depression [84,85]. Disrupted pattern of SN connectivity was reported in depression, especially in the insula and amygdala [86]. Elevated connectivity was found between the insula and DMN in patients with LLD [87].…”

Section: The Salience Networkmentioning

confidence: 95%

Crosstalk between Existential Phenomenological Psychotherapy and Neuroscience in Mood and Anxiety Disorders

Balogh¹,

Tanaka²,

Török³

et al. 2020

Preprint

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Psychotherapy is a comprehensive biological treatment modifying complex underlying cognitive, emotional, behavioral, and regulatory responses in the brain, leading patients with mental illness to a new interpretation of the sense of self and others. Psychotherapy is an art of science integrated with psychology and/or philosophy. Neuroscience is a multidisciplinary science of the neuron, the glial cells including oligodendrocytes, ependymal cells, and astrocytes and the neural circuits to understand learning, memory, behavior, perception, and consciousness. Both psychotherapy and neuroscience deal with the brain; nevertheless, they continue to stay polarized far. Existential phenomenological psychotherapy (EPP) has been in the forefront of meaning-centered counseling for almost a century. The phenomenological approach in psychotherapy originated in the works of Martin Heidegger, Ludwig Binswanger, Medard Boss and Viktor Frankl, and it has been committed to account for the existential possibilities and limitations of one’s life. EPP provides philosophically rich interpretations and empowers counseling techniques to assist mentally suffering individuals by finding meaning and purpose of life. The approach has proven to be effective in treating mood and anxiety disorders. This review article demonstrates the development of EPP, the therapeutic methodology, evidence-based accounts of its curative techniques, current understanding of mood and anxiety disorders in neuroscience, and a possible converging path to translate and integrate meaning-centered psychotherapy and neuroscience, concluding that the existential phenomenological approach in psychotherapy is a viable and potent alternative to the currently prevailing medication-based approaches.

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Brain structural and functional changes in patients with major depressive disorder: a literature review

Cited by 79 publications

References 81 publications

Olfactory markers for depression: Differences between bipolar and unipolar patients

Olfactory markers for depression: Differences between bipolar and unipolar patients

Alterations in internetwork functional connectivity in patients with chronic migraine within the boundaries of the Triple Network Model

Crosstalk between Existential Phenomenological Psychotherapy and Neuroscience in Mood and Anxiety Disorders

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