Brain structural changes associated with chronicity and antipsychotic treatment in schizophrenia

Tomelleri, Luisa; Jogia, Jigar; Perlini, Cinzia; Bellani, Marcella; Ferro, Adele; Rambaldelli, Gianluca; Tansella, Michele; Frangou, Sophia; Brambilla, Paolo

doi:10.1016/j.euroneuro.2009.07.007

Cited by 61 publications

(54 citation statements)

References 30 publications

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“…There is previous evidence that suggests medication may influence brain connectivity. Antipsychotic medication may cause grey matter volume changes in certain brain structures in schizophrenia (Tomelleri et al, 2009). Dopamine receptor antagonist has been shown to reduce global and local network efficiency in healthy adult brains (Achard and Bullmore, 2007).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

Chai

Whitfield-Gabrieli

Shinn

et al. 2011

Neuropsychopharmacol

293

205

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Bipolar disorder and schizophrenia overlap in symptoms and may share some underlying neural substrates. The medial prefrontal cortex (MPFC) may have a crucial role in the psychophysiology of both these disorders. In this study, we examined the functional connectivity between MPFC and other brain regions in bipolar disorder and schizophrenia using resting-state functional magnetic resonance imaging (fMRI). Resting-state fMRI data were collected from 14 patients with bipolar disorder, 16 patients with schizophrenia, and 15 healthy control subjects. Functional connectivity maps from the MPFC were computed for each subject and compared across the three groups. The three groups showed distinctive patterns of functional connectivity between MPFC and anterior insula, and between MPFC and ventral lateral prefrontal cortex (VLPFC). The bipolar disorder group exhibited positive correlations between MPFC and insula, and between MPFC and VLPFC, whereas the control group exhibited anticorrelations between these regions. The schizophrenia group did not exhibit any resting-state correlation or anticorrelation between the MPFC and the VLPFC or insula. In contrast, neither patient group exhibited the significant anticorrelation between dorsal lateral prefrontal cortex (DLPFC) and MPFC that was exhibited by the control group. The decoupling of DLPFC with MPFC in bipolar disorder and schizophrenia is consistent with the impaired executive functioning seen in these disorders. Functional connectivity between MPFC and insula/VLPFC distinguished bipolar disorder from schizophrenia, and may reflect differences in the affective disturbances typical of each illness.

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Section: Discussionmentioning

confidence: 99%

Abnormal Medial Prefrontal Cortex Resting-State Connectivity in Bipolar Disorder and Schizophrenia

Chai

Whitfield-Gabrieli

Shinn

et al. 2011

Neuropsychopharmacol

293

205

View full text Add to dashboard Cite

show abstract

“…Volumetric decreases with typicals were found in only one study [77], and thus these foci could not be metaanalyzed. Volumetric increases with typicals were found in two studies [77,83], but no significant clusters were found. Volumetric decreases with atypicals were reported in three studies [79,80,86], retrieving one significant cluster of 456 mm 3 located in the left temporal lobe, BA 20 (peak voxel at Talairach coordinate −48, -16-, -20).…”

Section: Resultsmentioning

confidence: 97%

“…Table 1 illustrates the clinical and demographic variables of the subjects included in the ten selected studies, which encompassed a total of 548 individuals (298 patients using typical or atypical antipsychotics and 250 controls). For the effect of reported coordinates included in this meta-analysis, five selected studies were classified as longitudinal [78,79,81,82,84] and five as cross-sectional [77,80,83,85,86]. Table 2 provides details on the methodologies of each selected study.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, ten studies [77][78][79][80][81][82][83][84][85][86] met the inclusion criteria (PRISMA flowchart in Figure 1). Additional data were necessary for the maps and peak coordinates reported in the study by Molina et al [86] and were provided by the authors after submitting a request via e-mail (personal communication).…”

Section: Resultsmentioning

confidence: 99%

“…From the subset of studies which specifically described the number of patients who had taken each antipsychotic [77,78,80,[82][83][84][85][86], olanzapine and risperidone were the most frequently used drugs among these 179 patients treated with atypicals, being used for 40.7% (73) and 30.1% (54) of the patients, respectively. Typical antipsychotics used when considering all the selected studies were chlorpromazine, sulpiride, haloperidol, thioridazine, droperidol, trifluoperazine, zuclopenthixol, fluphenazine and clotiapine.…”

Section: Resultsmentioning

confidence: 99%

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