Brain T1 in young children with sickle cell disease: evidence of early abnormalities in brain development

Term neonate prognoses after perinatal asphyxia: contributions of MR imaging, MR spectroscopy, relaxation times, and apparent diffusion coefficients.

“…Because the MR signal intensity is mainly related to water content, the edema should have increased the T1 and T2 values in the two groups in the same way and thereby decreased the effect of hypoxia on relaxation changes. This hypothesis is difficult to verify because relatively few studies with healthy neonates have been performed to determine normal relaxation times and the results of these investigations are discordant (38)(39)(40)(41)(42). T1 values of 1700 -2300 msec in white matter and 1140 -1500 msec in gray matter have been reported (38,39).…”

“…This hypothesis is difficult to verify because relatively few studies with healthy neonates have been performed to determine normal relaxation times and the results of these investigations are discordant (38)(39)(40)(41)(42). T1 values of 1700 -2300 msec in white matter and 1140 -1500 msec in gray matter have been reported (38,39). The ranges of T2 values are greater, ranging between 130 and 394 msec in white matter and between 100 and 206 msec in the basal ganglia (38,(40)(41)(42).…”

Rapid MRI method for mapping the longitudinal relaxation time

“…The diagnostic value of tissue's longitudinal relaxation time is being actively explored (for example, [29][30][31][32][33][34]). The authors hope the present rapid method can be of help in facilitating dynamic studies and clinical assessment of disease.…”

Computer-aided detection of therapy-induced leukoencephalopathy in pediatric acute lymphoblastic leukemia patients treated with intravenous high-dose methotrexate

“…While difference measures compensate for age differences between patients by using an internal control (normal-appearing genu), it has been demonstrated previously that the T1 relaxation time of the genu reaches adult values at approximately 3 years of age [19]. This means that our referencing of suspected abnormal regions to the genu values adjusts for measurement variability, but has very little adjustment for age in older subjects.…”