Brain Targeted Curcumin Loaded Turmeric Oil Microemulsion Protects Against Trimethyltin Induced Neurodegeneration in Adult Zebrafish: A Pharmacokinetic and Pharmacodynamic Insight

More, Suraj; Pawar, Atmaram

doi:10.1007/s11095-022-03467-9

Cited by 10 publications

(3 citation statements)

References 59 publications

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“…Various curcumin-encapsulating microemulsions, optimized for specific therapeutic tasks or administration routes, have been reported. For example, a microemulsion formulated with curcumin, turmeric oil and a mixture of Kolliphor RH40-ethanol as a surfactant-cosurfactant pair exhibited a protective effect against induced neurodegeneration in zebrafish, as reported by More et al [15]. Amuti et al reported a microemulsion with Cremophor EL/ethanol as a surfactant mixture and isoamyl acetate oily phase that shows superior antioxidant stability [16].…”

Section: Introductionmentioning

confidence: 77%

Preparation and In Vitro Characterization of Alkyl Polyglucoside-Based Microemulsion for Topical Administration of Curcumin

et al. 2023

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The skin is a complex and selective system from the perspective of permeability to substances from the external environment. Microemulsion systems have demonstrated a high performance in encapsulating, protecting and transporting active substances through the skin. Due to the low viscosity of microemulsion systems and the importance of a texture that is easy to apply in the cosmetic and pharmaceutical fields, gel microemulsions are increasingly gaining more interest. The aim of this study was to develop new microemulsion systems for topical use; to identify a suitable water-soluble polymer in order to obtain gel microemulsions; and to study the efficacy of the developed microemulsion and gel microemulsion systems in the delivery of a model active ingredient, namely curcumin, into the skin. A pseudo-ternary phase diagram was developed using AKYPO® SOFT 100 BVC, PLANTACARE® 2000 UP Solution and ethanol as a surfactant mix; caprylic/capric triglycerides, obtained from coconut oil, as the oily phase; and distilled water. To obtain gel microemulsions, sodium hyaluronate salt was used. All these ingredients are safe for the skin and are biodegradable. The selected microemulsions and gel microemulsions were physicochemically characterized by means of dynamic light scattering, electrical conductivity, polarized microscopy and rheometric measurements. To evaluate the efficiency of the selected microemulsion and gel microemulsion to deliver the encapsulated curcumin, an in vitro permeation study was performed.

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Section: Introductionmentioning

confidence: 77%

Preparation and In Vitro Characterization of Alkyl Polyglucoside-Based Microemulsion for Topical Administration of Curcumin

et al. 2023

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“…addition, trimethyltin or aluminum trichloride-induced neurodegeneration model in zebrafish was also used to evaluate the neuro-modulatory activity of EOs and their products (Chen et al, 2021b;More and Pawar, 2023).…”

Section: Zebrafish Models For the Evaluation Of Angiogenesis Inhibito...mentioning

confidence: 99%

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

Wang,

Yu,

Ding

et al. 2023

Qual. Assur. Saf. Crops Foods

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Essential oils (EOs) derived from crops, especially aromatic plants, have been well-acknowledged to provide several health benefits for humans. Zebrafish as an unprecedented tool has been widely used as an excellent vertebrate model in labs owing to its many useful characteristics. Its applications for rapidly and economically screening and identifying toxicity, safety, and bioactivity of EOs may serve to meet the rising demand for nutraceuticals, food supplements, and natural cosmetics. In this study, we summarized the research progress of zebrafish models in evaluating EOs. In addition, toxicity, safety, and various bioactivities of EOs were summarized using a wide variety of readily applicable zebrafish models covering antioxidant, anti-inflammatory, angiogenesis inhibition, neuromodulation, anesthesia, anti-melanogenesis, analgesic activities, etc. In conclusion, zebrafish is a valuable animal model for evaluating the bioactivity and safety of EOs, and using such a model may contribute to speeding up the identification of novel EOs with potential health functions and quality assessment, which in turn boosts the recognition of aromatic plants as important industrial crops and encourages a healthier way of life.

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“…Using curcumin for therapeutic purposes in humans shows limitations, including low absorption, rapid degradation, metabolism, and excretion rates. Therefore, various studies have been conducted to increase the oral bioavailability of curcumin (Jamwal, 2018; More & Pawar, 2023). According to recent data, products such as NovaSol® (185), CurcuWin® (136), and LongVida® (100) exhibited over100‐fold higher bioavailability relative to reference unformulated curcumin (Gupta et al., 2020; Jäger et al., 2014; Jamwal, 2018; Schiborr et al., 2014).…”

Section: Introductionmentioning

confidence: 99%

A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury

Sakul,

Balcikanli,

Ozsoy

et al. 2024

Chem Biol Drug Des

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A novel curcumin formulation increases relative absorption by 46 times (CurcuWIN®) of the total curcuminoids over the unformulated standard curcumin form. However, the exact mechanisms by which curcumin demonstrates its neuroprotective effects are not fully understood. This study aimed to investigate the impact of a novel formulation of curcumin on the expression of brain‐derived neurotrophic factor (BDNF), glial fibrillary acidic protein (GFAP), a main component of the glial scar and growth‐associated protein‐43 (GAP‐43), a signaling molecule in traumatic brain injury (TBI). Mice (adult, male, C57BL/6j) were randomly divided into three groups as follows: TBI group (TBI‐induced mice); TBI + CUR group (TBI mice were injected i.p. curcumin just after TBI); TBI+ CurcuWIN® group (TBI mice were injected i.p. CurcuWIN® just after TBI). Brain injury was induced using a cold injury model. Injured brain tissue was stained with Cresyl violet to evaluate infarct volume and brain swelling, analyzed, and measured using ImageJ by Bethesda (MD, USA). Western blot analysis was performed to determine the protein levels related to injury. While standard curcumin significantly reduced brain injury, CurcuWIN® showed an even greater reduction associated with reductions in glial activation, NF‐κB, and the inflammatory cytokines IL‐1β and IL‐6. Additionally, both standard curcumin and CurcuWIN® led to increased BDNF, GAP‐43, ICAM‐1, and Nrf2 expression. Notably, CurcuWIN® enhanced their expression more than standard curcumin. This data suggests that highly bioavailable curcumin formulation has a beneficial effect on the traumatic brain in mice.

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Brain Targeted Curcumin Loaded Turmeric Oil Microemulsion Protects Against Trimethyltin Induced Neurodegeneration in Adult Zebrafish: A Pharmacokinetic and Pharmacodynamic Insight

Cited by 10 publications

References 59 publications

Preparation and In Vitro Characterization of Alkyl Polyglucoside-Based Microemulsion for Topical Administration of Curcumin

Preparation and In Vitro Characterization of Alkyl Polyglucoside-Based Microemulsion for Topical Administration of Curcumin

Zebrafish models for the evaluation of essential oils (EOs): A comprehensive review

A highly bioavailable curcumin formulation ameliorates inflammation cytokines and neurotrophic factors in mice with traumatic brain injury

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