2013
DOI: 10.4172/2167-1095.1000160
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Brain-Targeted (Pro) Renin Receptor Knockdown Modulates Body Fluid Homeostasis

Abstract: Objectives: The (pro) renin receptor (PRR) is highly expressed in the brain and is involved in the central regulation of blood pressure. However, the role of the brain PRR in regulating body fluid homeostasis in hypertension remains unclear. We hypothesized that the brain PRR knockdown modulates water intake, urine, and urinary sodium excretion in the context of angiotensin II (Ang II)-induced hypertension. Methods and Results: Brain PRR was knocked down in non-transgenic (NT) normotensive and human reninangio… Show more

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