Brain tissue volume changes in relapsing-remitting multiple sclerosis: correlation with lesion load

Brain Volume and Diffusion Markers as Predictors of Disability and Short-Term Disease Evolution in Multiple Sclerosis

“…BPF shared only a low proportion of variance with WMLL perc (ϳ22%), as reported by Guttman et al 49 and Simon et al, 50 confirming that both the pathology of the normal WM and cortical processes contribute substantially to brain atrophy. 31,34,51 Moderate correlations between BPF and the MSFC sum scores, as described by Kalkers et al, 52 and with the 9-HPT could be established. No correlation with the PASAT was found, as shown in a previous negative report.…”

“…[22][23][24] Serial application of DWI revealed progressive microstructural GM changes in untreated relapsing-remitting MS, 25 and a good prediction of the potential for the clinical status after 5 years in primary-progressive MS. 26 Despite the sensitivity of DWI, however, there are scant serial data on longitudinal DWI measures, particularly in treated relapsing-remitting MS and in combination with sensitive clinical monitoring instruments such as the MSFC score. 27 Furthermore, serial studies have either focused on DWI 25,26,28,29 or brain volume measurements, 6,9,11,14,[30][31][32][33][34][35][36] with only 1 serial study on primary-progressive MS and secondary-progressive MS using both techniques. 37 In this prospective, longitudinal, and multimodal MRI study on patients with MS under treatment, we investigated the potential of whole-brain diffusivity and brain volume for the prediction of cross-sectional disability and short-to-medium-term clinical evolution.…”

Spatiotemporal distribution pattern of white matter lesion volumes and their association with regional grey matter volume reductions in relapsing‐remitting multiple sclerosis

“…Recently, research has focused on the tissue compartments and regions within which brain atrophy occurs [Chard et al, 2002;Chen et al, 2004;Dalton et al, 2004;De Stefano et al, 2003;Jasperse et al, 2007;Pagani et al, 2005;Prinster et al, 2006;Quarantelli et al, 2003;Sailer et al, 2003;Sepulcre et al, 2006;Tedeschi et al, 2005;Tiberio et al, 2005]. Previous VBM studies, as well as studies using other image analysis methods, have shown GM changes in MS patients in both cortical and deep GM regions [Audoin et al, 2006;Battaglini et al, 2009;Bendfeldt et al, 2009a;Chen et al, 2004;Pagani et al, 2005;Sepulcre et al, 2006].…”

“…Quantitative MRI indicates that GM atrophy develops faster than WM atrophy , occurs even in the earliest stages of the disease [Chard et al, 2002;Chard et al, 2004;Dalton et al, 2004] and is more related to physical disability and cognitive impairment [Amato et al, 2004;Chard et al, 2002;Dalton et al, 2004;De Stefano et al, 2003;Ge et al, 2001;Quarantelli et al, 2003;Sailer et al, 2003;Sanfilipo et al, 2005;Sanfilipo et al, 2006;Tiberio et al, 2005] than WM-lesion volumes. To date, however, the spatiotemporal relations between regional WM and GM changes are less well understood.…”

Segmentation of multiple sclerosis lesions in MR images: a review

“…Also, the rate of cerebral atrophy is a detectable outcome measure in short term clinical trials in RRMS and applicable in terms of study power while a potent drug is applied [6]. Quarantelli et al [7], Pagani et al [8], Horakova et al [9], Fisher et al [10], and Fisniku et al [11] have confirmed that tissue loss in GM compartment is greater than the WM. Moreover, GM atrophy can present very early in some patients, increasing GM but not WM atrophy over the short-to mid-term in different stages of RRMS.…”