Brain to periphery in acute ischemic stroke: Mechanisms and clinical significance

Cui, Pan; McCullough, Louise D.; Hao, Junwei

doi:10.1016/j.yfrne.2021.100932

Cited by 36 publications

(28 citation statements)

References 205 publications

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“…First, SAP, unlike simple bacterial infections, is a respiratory syndrome caused by a complex interaction between bacterial, chemical, and immunocompromising factors. 35 This is the reason why prophylactic antibiotics neither reduce the incidence of SAP nor improve its prognosis. 39 , 40 Immunosuppression is one of the main mechanisms leading to the development of SAP, and immunosuppression is highly correlated with NLR, which makes NLR a more effective predictor of the development of SAP.…”

Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio Better Than High-Sensitivity C-Reactive Protein in Predicting Stroke-Associated Pneumonia in Afebrile Patients

Wu¹,

Zhang²,

Tian³

et al. 2021

NDT

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Purpose To evaluate the association between neutrophil-to-lymphocyte ratio (NLR) and stroke-associated pneumonia (SAP) in patients with acute ischemic stroke (AIS) without fever and to clarify whether NLR has an advantage over high-sensitivity C-reactive protein (hs-CRP) in predicting SAP. Patients and Methods A total of 434 patients with AIS without fever were assessed in this study. Multivariable analysis was used to evaluate the relationship between NLR and SAP, and the receiver operating characteristic (ROC) curve was used to compare the predictive value of NLR and hs-CRP. Results Among the total patients, 18 (4.1%) developed SAP. After adjusting for confounders, NLR (adjusted odds ratio [aOR] = 1.60; 95% confidence interval [CI], 1.30–1.96; p < 0.001) remained independently associated with an increased risk of SAP. In addition, the area under the curve (AUC) of NLR (0.862 [0.826–0.893]) was higher than that of hs-CRP (0.738 [0.694–0.779]). Conclusion We found that compared with hs-CRP, NLR was significantly associated with the occurrence of SAP in patients with AIS without fever and showed a more effective predictive value for SAP.

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Section: Discussionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio Better Than High-Sensitivity C-Reactive Protein in Predicting Stroke-Associated Pneumonia in Afebrile Patients

Wu¹,

Zhang²,

Tian³

et al. 2021

NDT

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“…In addition, propranolol exhibits adjuvant activity in the breast cancer vaccine model by modulating cytokines and TNF-α [ 216 , 217 ]. Propranolol was also reported to control acute ischemic stroke patients with lymphopenia through its role in enhancing TNF-α, IL-10, and TNF-α/IL-10 [ 218 , 219 ]. Furthermore, it was reported to protect dopaminergic neurons in rats with experimentally induced parkinsonism TNF-α production suppression [ 220 , 221 ].…”

Section: Resultsmentioning

confidence: 99%

Sustainable Release of Propranolol Hydrochloride Laden with Biconjugated-Ufasomes Chitosan Hydrogel Attenuates Cisplatin-Induced Sciatic Nerve Damage in In Vitro/In Vivo Evaluation

et al. 2022

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Peripheral nerve injuries significantly impact patients’ quality of life and poor functional recovery. Chitosan–ufasomes (CTS–UFAs) exhibit biomimetic features, making them a viable choice for developing novel transdermal delivery for neural repair. This study aimed to investigate the role of CTS–UFAs loaded with the propranolol HCl (PRO) as a model drug in enhancing sciatica in cisplatin-induced sciatic nerve damage in rats. Hence, PRO–UFAs were primed, embedding either span 20 or 60 together with oleic acid and cholesterol using a thin-film hydration process based on full factorial design (24). The influence of formulation factors on UFAs’ physicochemical characteristics and the optimum formulation selection were investigated using Design-Expert® software. Based on the optimal UFA formulation, PRO–CTS–UFAs were constructed and characterized using transmission electron microscopy, stability studies, and ex vivo permeation. In vivo trials on rats with a sciatic nerve injury tested the efficacy of PRO–CTS–UFA and PRO–UFA transdermal hydrogels, PRO solution, compared to normal rats. Additionally, oxidative stress and specific apoptotic biomarkers were assessed, supported by a sciatic nerve histopathological study. PRO–UFAs and PRO–CTS–UFAs disclosed entrapment efficiency of 82.72 ± 2.33% and 85.32 ± 2.65%, a particle size of 317.22 ± 6.43 and 336.12 ± 4.9 nm, ζ potential of −62.06 ± 0.07 and 65.24 ± 0.10 mV, and accumulatively released 70.95 ± 8.14% and 64.03 ± 1.9% PRO within 6 h, respectively. Moreover, PRO–CTS–UFAs significantly restored sciatic nerve structure, inhibited the cisplatin-dependent increase in peripheral myelin 22 gene expression and MDA levels, and further re-established sciatic nerve GSH and CAT content. Furthermore, they elicited MBP re-expression, BCL-2 mild expression, and inhibited TNF-α expression. Briefly, our findings proposed that CTS–UFAs are promising to enhance PRO transdermal delivery to manage sciatic nerve damage.

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“…The segmentation performance of the algorithm was assessed regarding sensitivity, specificity, and overall performance. Parametric deformation (PD) [ 17 ] and geometric deformation (GD) models [ 18 ] were compared with the proposed algorithm:

where TP is true positive, TN is true negative, FP is false positive, and FN is false negative.…”

Section: Methodsmentioning

confidence: 99%

Traumatic Brain Magnetic Resonance Imaging Feature Extraction Based on Variable Model Algorithm in Stroke Examination

Yang

et al. 2022

Contrast Media & Molecular Imaging

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The purpose of this study was to explore the diagnostic value of different sequence scanning of nonparametric variable model-based cranial magnetic resonance imaging (MRI) for ischemic stroke. A histogram analysis-based nonparametric variable model was proposed first, which was compared with the parametric deformation (PD) model and geometric deformation (GD) model. Then, 116 patients with acute ischemic stroke were selected as the research subjects. Routine MRI (T2WI, T1WI, FLAIR, DWI, SWI, and 3D TOF MRA) and MR SCALE-PWI were performed. The results showed that the nonparametric variable model algorithm was relatively complete in the actual segmentation results of MRI images, and the display clarity of lesions was better than PD and GD algorithms. The diagnostic sensitivity, specificity, and overall performance of the variable model algorithm were significantly higher than those of the other two algorithms ( P < 0.05 ). According to ROC curve analysis, the AUC areas of DWI, SWI, 3D TOF MRA, and MR SCALE-PWI for the diagnosis of ischemic penumbra were 0.793, 0.825, 0.871, and 0.933, respectively. In summary, the segmentation results of MRI images by the nonparametric variable model based on histogram analysis were relatively complete, and the clarity of lesions was better than that of the traditional model. MRI images can effectively identify the occurrence of ischemic stroke. Moreover, MR SCALE-PWI had a good early identification effect on ischemic penumbra, which can reduce unnecessary treatment for patients.

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Brain to periphery in acute ischemic stroke: Mechanisms and clinical significance

Cited by 36 publications

References 205 publications

Neutrophil-to-Lymphocyte Ratio Better Than High-Sensitivity C-Reactive Protein in Predicting Stroke-Associated Pneumonia in Afebrile Patients

Neutrophil-to-Lymphocyte Ratio Better Than High-Sensitivity C-Reactive Protein in Predicting Stroke-Associated Pneumonia in Afebrile Patients

Sustainable Release of Propranolol Hydrochloride Laden with Biconjugated-Ufasomes Chitosan Hydrogel Attenuates Cisplatin-Induced Sciatic Nerve Damage in In Vitro/In Vivo Evaluation

Traumatic Brain Magnetic Resonance Imaging Feature Extraction Based on Variable Model Algorithm in Stroke Examination

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