Brain Tumors and Salivary Gland Cancers Among Cellular Telephone Users

Auvinen, Anssi; Hietanen, Maila; Luukkonen, Ritva; Koskela, Riitta‐Sisko

doi:10.1097/00001648-200205000-00018

Cited by 208 publications

(144 citation statements)

References 6 publications

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“…However, there is still contradictory evidence to support a link between the two. A Finnish study performed about 10 years ago failed to support any connection between the use of cell phones with SGTs [27]; however, that study focused only on cases of SGTs registered during 1 year (1996), at a time that cell phone use was not as widespread as today.…”

Section: Discussionmentioning

confidence: 99%

Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

Bello

Salo

Dayan

et al. 2012

Head and Neck Pathol

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Salivary gland tumors (SGTs) of epithelial origin are relatively rare, and worldwide reports show considerable variations in their epidemiology. The aim of this study was to examine, for the first time, the records of SGTs from two very distant geographical locations, Finland (two medical centers) and Israel (one medical center) between 1999 and 2008, based exclusively on the 2005 WHO classification of head and neck tumors, and to compare those data to the other available (single-center) studies that used the same classification. A total of 2,218 benign and malignant tumors diagnosed in the three centers were analyzed. Differences in classification of the tumors were found between the two geographical locations as well as between the two centers from Finland. There was a higher ratio of benign-to-malignant SGTs in the Finnish centers (5.4:1 and 7:1) compared to the Israeli center (2:1), a higher frequency of tumors of minor salivary glands in the Israeli center (34%) than in the Finnish centers (4 and 11%), and a higher frequency of malignant SGTs in the minor salivary glands in Israel (64.5%) than in Finland (10.9 and 27%). The diversity of these multicenter data are compatible with reports from different parts of the world. We conclude that conducting epidemiologic surveys based on the latest WHO classification provides clinicopathologic correlations on SGTs that seem to be characteristic even in small geographical regions.

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Section: Discussionmentioning

confidence: 99%

Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

Bello

Salo

Dayan

et al. 2012

Head and Neck Pathol

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“…A meta-analysis also failed to reveal any significant association between long-term mobile phone use and intracranial tumors. 24 Most earlier studies [3][4][5][6][7][8] did not have sufficient numbers of long-term mobile phone users for meaningful risk assessment, if there is a latency of at least 5-10 years.…”

Section: Discussionmentioning

confidence: 99%

“…The studies published on the issue have covered a relatively small number of study subjects with long-term exposure, and so far the epidemiological evidence does not suggest any clear increase of intracranial tumors related to mobile phone use, although some positive findings have been reported. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] We conducted a collaborative population-based case-control study on the association of mobile phone use with intracranial tumors in 5 Northern European countries, using a shared protocol of the INTERPHONE study coordinated by the International Agency for Research on Cancer. 20 We report here the results concerning glioma, based on the combined data from Denmark, Finland, Norway, Sweden and Southeast England, where mobile phones have been widely used for at least a decade.…”

mentioning

confidence: 99%

Mobile phone use and risk of glioma in 5 North European countries

Lahkola

Auvinen

Raitanen

et al. 2007

Intl Journal of Cancer

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162

127

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Public concern has been expressed about the possible adverse health effects of mobile telephones, mainly related to intracranial tumors. We conducted a population-based case-control study to investigate the relationship between mobile phone use and risk of glioma among 1,521 glioma patients and 3,301 controls. We found no evidence of increased risk of glioma related to regular mobile phone use (odds ratio, OR 5 0.78, 95% confidence interval, CI: 0.68, 0.91). No significant association was found across categories with duration of use, years since first use, cumulative number of calls or cumulative hours of use. When the linear trend was examined, the OR for cumulative hours of mobile phone use was 1.006 (1.002, 1.010) per 100 hr, but no such relationship was found for the years of use or the number of calls. We found no increased risks when analogue and digital phones were analyzed separately. For more than 10 years of mobile phone use reported on the side of the head where the tumor was located, an increased OR of borderline statistical significance (OR 5 1.39, 95% CI 1.01, 1.92, p trend 0.04) was found, whereas similar use on the opposite side of the head resulted in an OR of 0.98 (95% CI 0.71, 1.37). Although our results overall do not indicate an increased risk of glioma in relation to mobile phone use, the possible risk in the most heavily exposed part of the brain with long-term use needs to be explored further before firm conclusions can be drawn. ' 2007 Wiley-Liss, Inc.Key words: mobile phones; brain tumors; case-control studies Mobile phone use has increased rapidly worldwide since the early 1990s. Mobile phones emit radiofrequency electromagnetic fields that are non-ionizing radiation, i.e. have too low energy to break chemical bonds. Hence, such fields cannot cause DNA damage (mutations), which is required for cancer initiation. 1 However, radiofrequency fields might be involved in cancer development at later stages, including tumor progression or promotion. Despite the fact that no carcinogenic mechanism for radiofrequency radiation has been established, 2 there is public concern about the possible health effects of mobile phone use. This is mainly related to intracranial tumors, as mobile phones are used close to the head and the radiofrequency field is absorbed mostly in the head and neck region. The studies published on the issue have covered a relatively small number of study subjects with long-term exposure, and so far the epidemiological evidence does not suggest any clear increase of intracranial tumors related to mobile phone use, although some positive findings have been reported. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] We conducted a collaborative population-based case-control study on the association of mobile phone use with intracranial tumors in 5 Northern European countries, using a shared protocol of the INTERPHONE study coordinated by the International Agency for Research on Cancer. 20 We report here the results concerning glioma, based on the combined data from D...

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“…These risk factors were taken into account in the analysis to reduce the effect of a mixture of socioeconomic, lifestyle, environmental and occupational factors as well as diagnostic bias on the results. 31 Previous studies in the United States, Europe and China have been inconsistent regarding associations with rural dwelling 31,71 and educational level, 68,70,[72][73][74] but findings have been indicative of an increased brain tumor risk among married individuals. 31,73 Almost 19% of cohort members were considered potentially exposed to lead in their jobs for all probabilities and intensities combined, which is in line with prevalence estimates reported in other studies.…”

Section: Discussionmentioning

confidence: 99%

Brain cancer mortality and potential occupational exposure to lead: Findings from the National Longitudinal Mortality Study, 1979–1989

Wijngaarden

Dosemeci

2006

Intl Journal of Cancer

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We evaluated the association between potential occupational lead exposure and the risk of brain cancer mortality in the National Longitudinal Mortality Study (NLMS), which is a prospective census-based cohort study of mortality among the noninstitutionalized United States population (1979)(1980)(1981)(1982)(1983)(1984)(1985)(1986)(1987)(1988)(1989). The present study was limited to individuals for whom occupation and industry were available (n 5 317,968). Estimates of probability and intensity of lead exposure were assigned using a job-exposure matrix (JEM). Risk estimates for the impact of lead on brain cancer mortality were computed using standardized mortality ratio (SMR) and proportional hazards and Poisson regression techniques, adjusting for the effects of age, gender and several other covariates. Brain cancer mortality rates were greater among individuals in jobs potentially involving lead exposure as compared to those unexposed (age-and gender-adjusted hazard ratio (HR) 5 1.5; 95% confidence interval (CI) 5 0.9-2.3) with indications of an exposure-response trend (probability: low HR 5 0.7 (95% CI 5 0.2-2.2), medium HR 5 1.4 (95% CI 5 0.8-2.5), high HR 5 2.2 (95% CI 5 1.2-4.0); intensity: low HR 5 1.2 (95% CI 5 0.7-2.1), medium/high HR 5 1.9 (95% CI 5 1.0-3.4)). Brain cancer risk was greatest among individuals with the highest levels of probability and intensity (HR 5 2.3; 95% CI 5 1.3-4.2). These findings provide further support for an association between occupational lead exposure and brain cancer mortality, but need to be interpreted cautiously due to the consideration of brain cancer as one disease entity and the absence of biological measures of lead exposure. ' 2006 Wiley-Liss, Inc.

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Brain Tumors and Salivary Gland Cancers Among Cellular Telephone Users

Abstract: A register-based approach has limited value in risk assessment of cellular phone use owing to lack of information on exposure.

Cited by 208 publications

References 6 publications

Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

Epithelial Salivary Gland Tumors in Two Distant Geographical Locations, Finland (Helsinki and Oulu) and Israel (Tel Aviv): A 10-Year Retrospective Comparative Study of 2,218 Cases

Mobile phone use and risk of glioma in 5 North European countries

Brain cancer mortality and potential occupational exposure to lead: Findings from the National Longitudinal Mortality Study, 1979–1989

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