Brain tumors: detection with C-11 choline PET.

Shinoura, Nobusada; Nishijima, Michiharu; Hara, Tetsuo; Haisa, Toshihiko; Yamamoto, Hiroyuki; Fujii, Kiyotaka; Mitsui, Ikki; Kosaka, Noboru; Kondo, Tatsuya

doi:10.1148/radiology.202.2.9015080

Cited by 102 publications

(45 citation statements)

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“…High physiologic uptake is usually observed in the liver and the cortex of the kidneys and is furthermore observed in the duodenum and the pancreas because of secretion of phospholipid-rich pancreatic juice (19,21). High tumor uptake of 11 C-choline or 18 F-FEC has been reported for esophageal carcinoma (18), brain tumors (16,35), hepatocellular carcinoma (36), prostate cancer (17,37), and gynecologic malignancies (38). However, so far there have been no studies of 18 F-FEC PET in pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

Gene Expression Patterns and Tumor Uptake of¹⁸F-FDG,¹⁸F-FLT, and¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Forstner¹,

Egberts²,

Ammerpohl³

et al. 2008

J Nucl Med

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Section: Discussionmentioning

confidence: 99%

Gene Expression Patterns and Tumor Uptake of¹⁸F-FDG,¹⁸F-FLT, and¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Forstner¹,

Egberts²,

Ammerpohl³

et al. 2008

J Nucl Med

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“…In the brain, for example, choline is a substrate of choline containing phospholipids and of acetylcholine. 22,23 However, in tumors Cho is integrated mainly into phospholipids, 21,22 a major constituent of cell membranes. Cho is incorporated into cell membranes by adenosine triphosphate (ATP) dependent phosphorylation and transformed by choline kinase in phosphocholine (PCho).…”

Section: Introductionmentioning

confidence: 99%

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Cudalbu

Comment

Kurdzesau

et al. 2010

Phys. Chem. Chem. Phys.

102

125

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The increase of total choline in tumors has become an important biomarker in cancer diagnosis. Choline and choline metabolites can be measured in vivo and in vitro using multinuclear MRS. Recent in vivo 13 C MRS studies using labeled substrates enhanced via dynamic nuclear polarization demonstrated the tremendous potential of hyperpolarization for real-time metabolic studies. The present study demonstrates the feasibility of detecting hyperpolarized 15 N labeled choline in vivo in a rat head at 9.4 T. We furthermore report the in vitro (172 AE 16 s) and in vivo (126 AE 15 s) longitudinal relaxation times. We conclude that with appropriate infusion protocols it is feasible to detect hyperpolarized 15 N labeled choline in live animals.

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“…More specific information on the in vivo status of tumors may be acquired by the use of a radiopharmaceutical that is a proliferation marker, as proliferative activity is one of the key factors of malignant disease. Various approaches toward tumor-specific visualization have been described in the literature, including the use of radiolabeled amino acids (7), nucleosides (8)(9)(10), choline (11)(12)(13), and various receptor ligands (14)(15)(16)(17). Strictly speaking, only labeled nucleosides that are incorporated into DNA are true proliferation markers, but the tissue kinetics of radiopharmaceuticals tracing amino acid transport, membrane metabolism, enzyme activity, or receptor expression can be used as a surrogate marker of cellular proliferation if the activity of such processes is increased in rapidly dividing cells.…”

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confidence: 99%

Evaluation of 4′-[Methyl-¹¹C]Thiothymidine in a Rodent Tumor and Inflammation Model

Toyohara¹,

Elsinga²,

Ishiwata³

et al. 2012

J Nucl Med

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49-[methyl-11 C]thiothymidine ( 11 C-4DST) is a novel radiopharmaceutical that can be used for tumor imaging because of its rapid incorporation into DNA as a substrate for DNA synthesis. The in vivo stability of 11 C-4DST is much greater than that of natural thymidine, because of the presence of a sulfur atom in the 49-position. Here, we evaluated the tissue kinetics and biodistribution of 11 C-4DST in a rodent tumor and acute sterile inflammation model in comparison with the previously published biodistribution data of 39-deoxy-39-18 F-fluorothymidine ( 18 F-FLT), 18 F-FDG, 11 Ccholine, 11 C-methionine, and 2 s-receptor ligands in the same animal model. Methods: C6 tumor cells were implanted subcutaneously into the right shoulder and turpentine (0.1 mL) was injected intramuscularly into the left hind leg of male Wistar rats 11 d and 24 h, respectively, before the scanning day. The animals were anesthetized with isoflurane, and 11 C-4DST (20-50 MBq) was injected intravenously. A dynamic PET scan was performed for 60 min with either the shoulder or hind leg region in the field of view. The animals were sacrificed, and a biodistribution study was performed. Results: 11 C-4DST showed the highest tumor uptake (standardized uptake value, 4.93) of all radiopharmaceuticals tested. Its tumor-to-muscle concentration ratio (12.7) was similar to that of 18 F-FDG (13.2). The selectivity of 11 C-4DST for tumor as compared with acute inflammation was high (37.7), comparable to that of the s-ligand 18 F-FE-SA5845 and much higher than that of 18 F-FDG (3.5). Rapidly proliferating tissues (tumor and bone marrow) showed a steadily increasing uptake. In inflamed muscle, 11 C-4DST showed relatively rapid washout, and tracer concentrations in inflamed and noninflamed muscle were not significantly different at intervals greater than 40 min. Competition of endogenous thymidine for 11 C-4DST uptake in target tissues was negligible, in contrast to competition for 18 F-FLT uptake. Thus, pretreatment of animals with thymidine phosphorylase was not required before PET with 11 C-4DST. Conclusion: In our rodent model, 11 C-4DST showed high tumor uptake (sensitivity) and high tumor selectivity. The different kinetics of 11 C-4DST in rapidly proliferating and inflammatory tissue may allow distinction between tumor and acute inflammation in a clinical setting. These promising results for 11 C-4DST warrant further investigation in PET studies in patients with various types of tumors.

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Brain tumors: detection with C-11 choline PET.

Abstract: C-11 choline PET can depict brain tumors effectively. This method was clinically useful in patients who had undergone surgery.

Cited by 102 publications

References 0 publications

Gene Expression Patterns and Tumor Uptake of¹⁸F-FDG,¹⁸F-FLT, and¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Gene Expression Patterns and Tumor Uptake of¹⁸F-FDG,¹⁸F-FLT, and¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Evaluation of 4′-[Methyl-¹¹C]Thiothymidine in a Rodent Tumor and Inflammation Model

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Brain tumors: detection with C-11 choline PET.

Abstract: C-11 choline PET can depict brain tumors effectively. This method was clinically useful in patients who had undergone surgery.

Cited by 102 publications

References 0 publications

Gene Expression Patterns and Tumor Uptake of18F-FDG,18F-FLT, and18F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Gene Expression Patterns and Tumor Uptake of18F-FDG,18F-FLT, and18F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Feasibility of in vivo15N MRS detection of hyperpolarized 15N labeled choline in rats

Evaluation of 4′-[Methyl-11C]Thiothymidine in a Rodent Tumor and Inflammation Model

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Gene Expression Patterns and Tumor Uptake of¹⁸F-FDG,¹⁸F-FLT, and¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Gene Expression Patterns and Tumor Uptake of¹⁸F-FDG,¹⁸F-FLT, and¹⁸F-FEC in PET/MRI of an Orthotopic Mouse Xenotransplantation Model of Pancreatic Cancer

Evaluation of 4′-[Methyl-¹¹C]Thiothymidine in a Rodent Tumor and Inflammation Model