Brain tumors in infants: a study of 76 patients operated upon

Lapras, C; Jn, Guilburd; Guyotat, Jacques; Jd, Patet

doi:10.1007/bf00271388

Cited by 23 publications

(1 citation statement)

References 10 publications

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“…Herein, we report a case with the highest OS, characterized by a good quality of life and no major impact on global development. Historically, the mortality rate in infants undergoing surgery for primary brain tumors in the first two years of life has undoubtedly exceeded that for older children, ranging from 7.3% to 33% depending on the nature of the tumor, tumor size, age at surgery, surgical blood loss, and actual definition of surgery-related death [35][36][37][38][39]. However, advances in preoperative planning and imaging, microneurosurgical techniques, pediatric neuroanesthesia, and dedicated postoperative PICU can achieve very low mortality rates [16,40].…”

Section: Discussionmentioning

confidence: 99%

Pediatric Posterior Fossa ATRT: A Case Report, New Treatment Strategies and Perspectives

et al. 2023

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Posterior fossa atypical teratoid rhabdoid tumor (ATRT) is a rare childhood tumor usually associated with a dismal prognosis. Although upfront surgical gross total resection (GTR) has classically been the first line of treatment, new multimodal treatments, including two-stage surgery, are showing promising results in terms of overall survival (OS) and complication rate. We present a case of a 9-month-old child treated with two-staged surgery and chemotherapy. When deemed risky, multimodal treatments, including staged surgeries, can be a safe alternative to reduce surgical mortality and morbidity. At 23 months old, the patient had normal global development and no major impact on quality of life. We, therefore, discuss the most recent advancements from a treatment perspective, including molecular targeting.

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Section: Discussionmentioning

confidence: 99%

Pediatric Posterior Fossa ATRT: A Case Report, New Treatment Strategies and Perspectives

et al. 2023

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Prenatal diagnosis of a craniopharyngioma using ultrasonography and magnetic resonance imaging

et al. 1990

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We report an infant with a craniopharyngioma which was detected in utero. Maternal uterine ultrasonography, done at 27 weeks because of polyhydramnios, revealed a 4 cm midline mass near the base of the fetal skull. At 31 weeks, magnetic resonance imaging of the maternal abdomen confirmed the presence of a mass in the region of the third ventricle and revealed hydrocephalus. Two days post-partum a computed tomography (CT)-guided needle biopsy of the mass was performed and recovered tissue which was histologically consistent with a craniopharyngioma. The infant's postnatal period was complicated by seizures, which were treated with phenobarbital, and by progressive hydrocephalus, necessitating placement of a ventriculo-peritoneal shunt. He also received therapy for central hypothyroidism and diabetes insipidus. The infant's parents refused permission for attempted resection of the tumour and he died at 8 weeks of age. This represents the second reported case of an antenatally detected craniopharyngioma. Four other cases of different intracranial tumours have been detected in utero using ultrasound, with no reported survivors past 3 days of age. There is a uniformly poor prognosis of such infants, but earlier diagnosis and intervention may change this result.

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Intracranial Tumors in the First Year of Life

Salomão

Protzenko

2023

Advances and Technical Standards in Neurosurgery

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Brain tumors in infants: a study of 76 patients operated upon

Cited by 23 publications

References 10 publications

Pediatric Posterior Fossa ATRT: A Case Report, New Treatment Strategies and Perspectives

Pediatric Posterior Fossa ATRT: A Case Report, New Treatment Strategies and Perspectives

Prenatal diagnosis of a craniopharyngioma using ultrasonography and magnetic resonance imaging

Intracranial Tumors in the First Year of Life

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