Brain-type natriuretic peptide levels correlate with pulmonary hypertension and requirement for extracorporeal membrane oxygenation in congenital diaphragmatic hernia

B-type natriuretic peptide: Usefulness in the management of critically-ill neonates

“…31 Baptista et al 32 studied BNP levels in patients with congenital diaphragmatic hernia (CDH) and observed an association among BNP levels, the severity of PHT, and mortality in this population. Other authors have reported that serial measurements of BNP levels among NBIs with CDH predicted the severity of PHT and ECMO requirement, 33 which was consistent with our findings.…”

Brain natriuretic peptide levels predict 6-month mortality in patients with cardiogenic shock who were weaned off extracorporeal membrane oxygenation

“…The role of BNP has rarely been investigated in patients receiving ECMO – only case reports or studies of children were found in a literature search. [ 30 , 37 , 38 ] In 2006, Huang et al reported that BNP levels of children on the fourth day after removal from ECMO were significantly lower in survivors than non-survivors, which was consistent with our findings. [ 30 ] They suggested that serial BNP levels can be a valuable parameter for monitoring patients on ECMO.…”

Association of BNP, NTproBNP, and early postnatal pulmonary hypertension in very preterm infants

“…A retrospective series including 132 infants with CDH and a median gestational age at delivery of 38 weeks by Partridge et al reported rather conflicting results. BNP levels were elevated pre‐CDH repair for infants with PH, however, there was no difference in BNP levels compared to CDH infants without PH within 30 days post‐surgery and beyond 30 days post‐surgery, respectively …”

“…In recent studies, B‐type natriuretic peptide (BNP) has been shown to correlate with the severity of PH in preterm and term newborns with PPHN or PH related to BPD or CDH . The inactive by‐product of BNP, N‐terminal‐pro‐BNP (NTproBNP), has not been studied yet with regards to PH in newborns.…”