Brain Volume and Doppler Velocimetry in Growth-Restricted, Small-for-Gestational-Age, and Appropriate-for-Gestational-Age Fetuses

Latif, Hala A. E. Wahab Abdel; Gaafar, Hassan Mostafa; Moety, Ghada Abdel Fattah Abdel; Mahmoud, Doaa; Rifai, N.

doi:10.1055/s-0036-1586752

Cited by 3 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Latif et al 12 showed that the brain volume was significantly smaller in FGR group compared with AGA group ( p < 0.001), while no significant difference was found in brain volume between FGR group and SGA group. It seems that the decrease in brain volumes in SGA group despite that Doppler indices were within normal ranges but significantly different from AGA group, corroborate the hypothesis that redistribution of blood flow seems to be a sign of potential threat to the fetal brain.…”

Section: Discussionmentioning

confidence: 97%

“…This group include 3 studies with similar methodology: Latif et al (2017) 12 ; Benavides-Serralde et al (2009) 13 and Caetano et al (2015). 14 The highest quality score according to the checklist proposed by Ioannou et al (2012) 20 was achieved by Caetano et al 14 …”

Section: Discussionmentioning

confidence: 99%

“…Latif et al 12 studied whole brain volume FGR with abnormal UA or MCA Doppler, Benavides-Serralde et al 13 studied total intracranial, frontal, thalamic and cerebellar volumes in FGR fetuses with UA Doppler alterations and, finally, Caetano et al 14 studied brain, frontal, and cerebellar volumes in FGR with normal Doppler values. All studies where consistent in demonstrating a reduced brain volume in FGR fetuses regardless of Doppler values, this was more evident in fetuses below the 3rd percentile, but also evident in SGA fetuses comparing with AGA.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Silva

Pérez

2021

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

Fetal growth restriction (FGR) occurs when the fetus does not reach its intrauterine potential for growth and development as a result of compromise in placental function. It is a condition that affects 5 to 10% of pregnancies and is the second most common cause of perinatal morbidity and mortality. Children born with FGR are at risk of impaired neurological and cognitive development and cardiovascular or endocrine diseases in adulthood. The purpose of the present revision is to perform a literature search for evidence on the detection and assessment by ultrasound of brain injury linked to FGR during fetal life. Using a systematic approach and quantitative evaluation as study methodology, we reviewed ultrasound studies of the fetal brain structure of growth-restricted fetuses with objective quality measures. A total of eight studies were identified. High quality studies were identified for measurement of brain volumes; corpus callosum; brain fissure depth measurements, and cavum septi pellucidi width measurement. A low-quality study was available for transverse cerebellar diameter measurement in FGR. Further prospective randomized studies are needed to understand the changes that occur in the brain of fetuses with restricted growth, as well as their correlation with the changes in cognitive development observed.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Silva

Pérez

2021

Rev Bras Ginecol Obstet

View full text Add to dashboard Cite

show abstract

Reduced gyrification in fetal growth restriction with prenatal magnetic resonance images

Yehuda,

Rabinowich,

Zilberman

et al. 2024

Cerebral Cortex

View full text Add to dashboard Cite

Placental-related fetal growth restriction, resulting from placental dysfunction, impacts 3–5% of pregnancies and is linked to elevated risk of adverse neurodevelopmental outcomes. In response, the fetus employs a mechanism known as brain-sparing, redirecting blood flow to the cerebral circuit, for adequate supply to the brain. In this study we aimed to quantitatively evaluate disparities in gyrification and brain volumes among fetal growth restriction, small for gestational age and appropriate-for gestational-age fetuses. Additionally, we compared fetal growth restriction fetuses with and without brain-sparing. The study encompassed 106 fetuses: 35 fetal growth restriction (14 with and 21 without brain-sparing), 8 small for gestational age, and 63 appropriate for gestational age. Gyrification, supratentorial, and infratentorial brain volumes were automatically computed from T2-weighted magnetic resonance images, following semi-automatic brain segmentation. Fetal growth restriction fetuses exhibited significantly reduced gyrification and brain volumes compared to appropriate for gestational age (P < 0.001). Small for gestational age fetuses displayed significantly reduced gyrification (P = 0.038) and smaller supratentorial volume (P < 0.001) compared to appropriate for gestational age. Moreover, fetal growth restriction fetuses with BS demonstrated reduced gyrification compared to those without BS (P = 0.04), with no significant differences observed in brain volumes. These findings demonstrate that brain development is affected in fetuses with fetal growth restriction, more severely than in small for gestational age, and support the concept that vasodilatation of the fetal middle cerebral artery reflects more severe hypoxemia, affecting brain development.

show abstract

Quantified growth of the human embryonic heart

et al. 2021

View full text Add to dashboard Cite

The size and growth patterns of the components of the human embryonic heart have remained largely undefined. To provide these data, 3D heart models were generated from immunohistochemically stained sections of 10 human embryonic hearts ranging from Carnegie stage 10 till 23. Fifty-eight key structures were annotated and volumetrically assessed. Sizes of the septal foramina and atrioventricular canal opening were also measured. The heart grows exponentially throughout embryonic development. There was consistently less left than right atrial myocardium, and less right than left ventricular myocardium. We observed a later onset of trabeculation in the left atrium compared to the right. Morphometry showed that the rightward expansion of the atrioventricular canal starts in week 5. The septal foramina are less than 0.1 mm2 and are, therefore, much smaller than post-natal septal defects. This chronological, graphical atlas of the growth patterns of cardiac components in the human embryo provides quantified references for normal heart development. Thereby, this atlas may support early detection of cardiac malformations in the foetus.

show abstract

Brain Volume and Doppler Velocimetry in Growth-Restricted, Small-for-Gestational-Age, and Appropriate-for-Gestational-Age Fetuses

Cited by 3 publications

References 24 publications

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Prenatal Ultrasound Diagnosis of Biometric changes in the Brain of Growth Restricted Fetuses. A Systematic Review of Literature

Reduced gyrification in fetal growth restriction with prenatal magnetic resonance images

Quantified growth of the human embryonic heart

Contact Info

Product

Resources

About