Brain Volume and Perception of Cognitive Impairment in People With Multiple Sclerosis and Their Caregivers

Fenu, Giuseppe; Lorefice, Lorena; Carta, Elisa; Arru, M.; Carta, Alice; Fronza, Marzia; Coghe, Giancarlo; Frau, Jessica; Contu, F.; Barracciu, Maria Antonietta; Cocco, Eleonora

doi:10.3389/fneur.2021.636463

Cited by 2 publications

(2 citation statements)

References 32 publications

(35 reference statements)

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“…Lower values of FA and MD of CST were observed on MS patients in relation with healthy subject in a study carried out for El-Sourgy and col on 2015 [13]. frequently associated with memory deficits in MS patients [29,30].…”

Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis Brain: Beyond Hyperintense Images

Bárbara Aymeé Hernández

2023

Int J Radiol Imaging Technol

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Introduction: Multiple Sclerosis (MS) is defined as a chronic, inflammatory demyelinating disease of the central nervous system. It has a multifactorial origin and it is characterized by disabling inflammatory attacks in the central nervous system. It affects any functional system (visual, motor, sensory, coordination, language and sphincter control) and it is considered as more disabling not traumatic disease of young population in the world.Objective: Describe brain anatomic changes in a group of MS patients through post-processing image techniques and correlate it with clinic abnormalities.Method: Thirty patients with relapsing-remitting form of MS and thirty healthy subjects were recruited, they were paired in age and sex. T1 and T2 weighted, FLAIR and DTI 3T MRI scans were acquired. Tractography, Voxel Based Morphometry (VBM) and cortical thickness processing analysis were done. Results:In relation of MS patients, tractography revealed that corticospinal tract and optic radiation number of fibres were lower than healthy subjects (p = 0.02), (p = 0.00). The number of fibres of evaluated tracts does not diminish significantly when disease duration increasing (p = 0.66), (p = 0.07), (p = 0.32). VBM revealed brain atrophy on subcortical areas of frontal and parietal lobes, occipital lobe, periventricular areas, brainstem, pulvinar thalamus and hippocampus; external capsule, extreme capsule, optic radiation, caudal fibres, arcuate fasciculus, fornix, frontal inferior gyrus, corona radiata, subcortical areas of parietotemporo-occipital lobes, corpus callosum head, white matter of pons and medulla oblongata and cingulate gyrus of MS patients. Cortical thickness analysis did not show significantly differences between MS and healthy subjects (p = 0.26). However, it diminished when disease duration increased (p = 0.03). Conclusions:In our MS patient's series was demonstrated morphologic abnormalities of grey and white mater, principally of subcortical and brainstem structures. These abnormalities increase when some clinical aspects get worse.

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Section: Discussionmentioning

confidence: 99%

Multiple Sclerosis Brain: Beyond Hyperintense Images

Bárbara Aymeé Hernández

2023

Int J Radiol Imaging Technol

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“…BICAMS subtests were categorized as “impaired” or “not impaired”; with impairment defined as −1.5 SD below the mean value of the control group as recommended previously 28 (cutoff scores were: 22 for SDMT, 38 for CVLT, and 10 for BVMTR). CI was defined by impaired performance in at least one of the subtests 29 …”

Section: Methodsmentioning

confidence: 99%

Thalamic atrophy, duration of illness, and years of education are the best predictors of cognitive impairment in multiple sclerosis

Khedr

Desoky

Gamea

et al. 2022

Clinical & Exp Neuroim

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Background: Cognitive impairment (CI) is common in multiple sclerosis. We assessed the relationship between CI and demographic, motor disability, and volumetric brain atrophy in relapsing remitting multiple sclerosis (RRMS). Methods: In all, 43 RRMS patients and 40 age-sex-, and education-matched normal volunteers were enrolled. Assessments included: demographic, Expanded Disability Status Scale (EDSS); Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS); and brain volumetric assessment.Results: The mean age of onset of RRMS patients was 25.72 y and the mean number of attacks was 3.30 ± 2.33/year. The total brain volume, cerebral, and cerebellar hemispheres, brainstem as well as thalamic and hippocampal gray matter were significantly reduced in RRMS patients compared with controls. CI was detected in 41.9% of patients. Patients with CI had fewer years of education (P = .001), a higher number of attacks (P = .002), worse EDSS scores (P = .030); reduced gray matter volume, particularly of the thalamus, and hippocampus compared with patients without CI. There were significant negative correlations between CI with duration of illness, number of attacks, time elapsed between onset and diagnosis, and EDSS. Thalamic volume showed strong positive correlations with CI (P < .0001). The best predictors of CI were thalamic atrophy, duration of illness, and years of education (P = .001, .010, and .035 respectively). Conclusion:We confirmed the presence of gray matter atrophy of the brain in RRMS patients. Volumetric magnetic resonance imaging measures of thalamus, duration of illness, and years of education could be useful biomarkers of CI in RRMS.

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Brain Volume and Perception of Cognitive Impairment in People With Multiple Sclerosis and Their Caregivers

Cited by 2 publications

References 32 publications

Multiple Sclerosis Brain: Beyond Hyperintense Images

Multiple Sclerosis Brain: Beyond Hyperintense Images

Thalamic atrophy, duration of illness, and years of education are the best predictors of cognitive impairment in multiple sclerosis

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