Brain volumetric abnormalities in patients with anorexia and bulimia nervosa: A Voxel-based morphometry study

Evidence for Thalamocortical Circuit Abnormalities and Associated Cognitive Dysfunctions in Underweight Individuals with Anorexia Nervosa

“…Neuroimaging research has demonstrated metabolic, morphological, and functional connectivity abnormalities among patients with AN in frontal, temporal, and visual cortical regions, as well as within subcortical structures including the basal ganglia (Amianto et al, 2013;Cowdrey et al, 2014;Delvenne et al, 1995;Husain et al, 1992;Matsumoto et al, 2006;Takano et al, 2001;Yau et al, 2013). Relatively few studies, however, have investigated the thalamus, a subcortical region that, in part, relays output from the basal ganglia to the cortex through parallel corticostriato-thalamo-cortical (CSTC) loops (Alexander and Crutcher, 1990;Haber and Calzavara, 2009;Parnaudeau et al, 2013).…”

“…Amianto et al (2013) used anatomical MRI and voxel-based morphometry and reported reduced gray matter in a cluster overlapping the right thalamus. Moreover, single-photon emission computed tomography has shown hyperperfusion in the thalamus in AN, indicative of hypermetabolism (Takano et al, 2001).…”

Grey matter correlates of autistic traits in women with anorexia nervosa

“…4,7,10,[13][14][15] Our results are also consistent with the extensive literature on structural brain alterations in anorexia nervosa. 27,29,[36][37][38][39][40][41][42][43][44][45] Specifically, previous structural brain studies found grey matter reductions of the temporal lobe in patients with anorexia nervosa, 27,28 and a recent activation likelihood estimation (ALE) meta-analysis showed that the temporal lobe consistently exhibits reduced regional grey matter in patients with anorexia nervosa. 29 Our results are further supported by functional MRI studies that found reduced activations of brain regions linked to social cognition, including the superior temporal cortex 25 and TPJ, 22,23 in patients with anorexia nervosa.…”

Neuroimaging and Attachment in Eating Disorders: Parental Love Nurtues the Brain

“…Neuroimaging techniques lead to interesting results which may be relevant to the understanding of pathogenesis of EDs. Global cerebral and cerebellar grey matter (GM), white matter (WM) atrophy and ventricular enlargement has been found in AN [8][9][10][11]. Some cerebral areas such as thalamus, midbrain [12], para central lobule [13] hippocampus-amygdala complex [14] and anterior cingulate cortex [15] are particularly involved by AN malnutrition effects.…”