Brain-wide electrical dynamics encode individual appetitive social behavior

Mague, Stephen D.; Talbot, Austin; Blount, Cameron; Walder-Christensen, Kathryn K.; Duffney, Lara J.; Adamson, Elise; Bey, Alexandra L.; Ndubuizu, Nkemdilim; Thomas, Gwenaëlle E.; Hughes, Duncan B.; Grossman, Yael S.; Hultman, Rainbo; Sinha, Saurabh; Fink, Alexandra M.; Gallagher, Neil M.; Fisher, Rachel L.; Jiang, Yong‐Hui; Carlson, David; Dzirasa, Kafui

doi:10.1016/j.neuron.2022.02.016

Cited by 34 publications

(52 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall, both DEP + MS and CON displayed higher EN-social network activity when interacting with the social stimulus versus the object (Figure 3E). This result is consistent with observations in a genetic mouse model of autism, for which the EN-social network continues to be activated when these mice are engaged with a social stimulus (Mague et al, 2022).…”

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...supporting

confidence: 91%

“…The model features utilize LFP power, LFP synchrony, and spectral Granger causality (Geweke, 1982) resolved from 1 to 56 Hz. As reported by Mague et al (2022), the network generalized on a mouse-by-mouse basis to encode individual socially appetitive behavioral outcomes. Critically, the activity of EN-social predicts an animal's investigation of the social stimulus and correlates with an individual animal's social preference, reflecting the rewarding nature of social encounters on a mouse-by-mouse basis (Mague et al, 2022).…”

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...mentioning

confidence: 94%

“…As reported by Mague et al (2022), the network generalized on a mouse-by-mouse basis to encode individual socially appetitive behavioral outcomes. Critically, the activity of EN-social predicts an animal's investigation of the social stimulus and correlates with an individual animal's social preference, reflecting the rewarding nature of social encounters on a mouse-by-mouse basis (Mague et al, 2022). Notably, while the prominent signals, which compose EN-social, predict social behavior, the individual features (i.e., brain regions) do not strongly encode social versus object interactions on their own (Figure S4B).…”

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...mentioning

confidence: 94%

“…Combined prenatal stressors induce male-specific deficits in adult socio-appetitive encoding To address whether the increased preference ratio in adult DEP + MS males reflects altered social processing, we probed a brain network recently described to underlie normal social behavior in mice (Mague et al, 2022). Specifically, this network, hereafter referred to as EN-social, was characterized based on data collected from an untreated group of C57BL/6J WT mice performing an identical 10-day social appetitive task.…”

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...mentioning

confidence: 99%

See 3 more Smart Citations

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

et al. 2022

Self Cite

View full text Add to dashboard Cite

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...supporting

confidence: 91%

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...mentioning

confidence: 94%

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...mentioning

confidence: 94%

Section: Mia Alters Gene Expression In the Prefrontal Cortices Of Neo...mentioning

confidence: 99%

See 2 more Smart Citations

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

et al. 2022

Self Cite

View full text Add to dashboard Cite

“…Non-invasive therapies based on optogenetics have been reported to control memory and sociality via light irradiation of local areas of the brain and neurons, but in these experiments, optical fibers/LEDs are inserted directly into the irradiated areas of mice 16 – 19 . Therefore, AG and OSL caused by external pulsed NIR irradiation using AG probes may contribute to optogenetic therapy by enabling non-invasive and site-selective optical simulations of local areas.…”

Section: Discussionmentioning

confidence: 99%

Repetitive afterglow in zirconia by pulsed near-infrared irradiation toward biological temperature sensing

Ohashi

Takahashi

Terakado

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Photoluminescence provides information about the surrounding environment. In this study, aiming to develop a non-invasive deep body-temperature sensing method, we investigated photoluminescence properties of afterglow zirconia (ZrO2) by pulsed near-infrared (NIR) light irradiation based on the biological temperature. Pulsed light irradiation produced optically stimulated luminescence, followed by afterglow, with the property of repeating 100 times or more. Furthermore, the basic principle of temperature measurement was demonstrated through afterglow decay curve measurements. The use of harmless ZrO2 as a sensing probe and NIR light, which is relatively permeable to living tissues, is expected to realize temperature measurements in the brain and may also facilitate optogenetic treatment.

show abstract

Circuits underlying social function and dysfunction

Wang,

Yueh,

Chau

et al. 2023

Autism Research

View full text Add to dashboard Cite

Substantial advances have been made toward understanding the genetic and environmental risk factors for autism, a neurodevelopmental disorder with social impairment as a core feature. In combination with optogenetic and chemogenetic tools to manipulate neural circuits in vivo, it is now possible to use model systems to test how specific neural circuits underlie social function and dysfunction. Here, we review the literature that has identified circuits associated with social interest (sociability), social reward, social memory, dominance, and aggression, and we outline a preliminary roadmap of the neural circuits driving these social behaviors. We highlight the neural circuitry underlying each behavioral domain, as well as develop an interactive map of how these circuits overlap across domains. We find that some of the circuits underlying social behavior are general and are involved in the control of multiple behavioral aspects, whereas other circuits appear to be specialized for specific aspects of social behavior. Our overlapping circuit map therefore helps to delineate the circuits involved in the various domains of social behavior and to identify gaps in knowledge. Lay SummaryDifficulties with social function are a core feature of autism, and we currently lack a clear understanding of the brain circuitry underlying social behaviors. We reviewed the literature that has identified brain nodes and circuits associated with social interest, the rewarding nature of social interactions, memory for social partners, dominance, and aggression in rodents. Our review, which reveals that some nodes/circuits may be involved in the control of many aspects of social behaviors, whereas other nodes/circuits appear to specialize in the control of specific behaviors, identifies gaps in our current understanding of these circuits.

show abstract

Brain-wide electrical dynamics encode individual appetitive social behavior

Cited by 34 publications

References 38 publications

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

Prenatal environmental stressors impair postnatal microglia function and adult behavior in males

Repetitive afterglow in zirconia by pulsed near-infrared irradiation toward biological temperature sensing

Circuits underlying social function and dysfunction

Contact Info

Product

Resources

About