Brainstem auditory evoked potentials in children with autism spectrum disorder

Kamita, Mariana Keiko; Silva, Liliane Aparecida Fagundes; Magliaro, Fernanda Cristina Leite; Kawai, Rebeca Yuko Couto; Fernandes, Fernanda Dreux Miranda; Gentile, Carla

doi:10.1016/j.jpedp.2019.03.003

Cited by 3 publications

(6 citation statements)

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“…No one has demonstrated essential and consistent evidence of indicators for onset of ASD mainly due to heterogeneity of ASD diagnosis and the possibility of the developing trajectory of the brain and compensatory structural changes [23][24][25]. Some researchers have reported brainstem dysfunction in children with ASD by administrating auditory brainstem evoked responses or by the polyvagal theory [26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Primitive Reflexes in Very Low Birth Weight Infants Later Diagnosed with Autism Spectrum Disorder

Nagai

Nomura

Uemura

2019

Preprint

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Background: As early screening and diagnosis is very important in treatment of Autism Spectrum Disorder, we investigated the relationship between primitive reflexes and Autism Spectrum Disorder (ASD). Methods: Of 88 very low birth weight infants born from April 2010 to March 2012, subjects comprised 38 examined for 18 primitive reflexes between age 38 and 45 wks corrected age and followed-up over 6 yrs. ASD was diagnosed using Diagnostic and Statistical Manual of Mental Disorders fifth edition (DSM-5) and Autism Diagnostic Observation Schedule Second Edition (ADOS-2). We compared the number of abnormal primitive reflexes between two groups (11 children with and 19 without ASD) after excluding eight children with cerebral palsy in this case-control study. Results: The number of abnormal primitive reflexes differed significantly between groups, with hypoactive reflexes markedly higher in the ASD group (p=0.001). Conclusion: The result suggests primitive reflexes can be one of the key elements to identify ASD in low birth weight infants. Abnormal primitive reflexes of low birth weight infants with ASD in very early infancy may inform future research of the pathogenesis of ASD.

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Section: Discussionmentioning

confidence: 99%

Primitive Reflexes in Very Low Birth Weight Infants Later Diagnosed with Autism Spectrum Disorder

Nagai

Nomura

Uemura

2019

Preprint

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“…Ainda no que tange aos aspectos metodológicos, observouse que a maioria dos estudos foi realizado com estímulo nãoverbal (4,24,25,(27)(28)(29)(30)(31)(32)(33) . Um estudo analisado na presente revisão utilizou apenas o estímulo verbal (34) , três estudos utilizaram ambos os estímulos (23,34,35) e ainda um estudo utilizou estímulos de sons biológicos (estalo de dedo e sucção de boca) (36) (Quadro 2). Gonzalez-Gadea et al (32) Prospectivo Transversal 24 ( Kamita (35) Prospectivo Transversal Matas et al (24) Não-verbal (tone burst).…”

Section: Análise Dos Estudos Selecionadosunclassified

“…Um estudo analisado na presente revisão utilizou apenas o estímulo verbal (34) , três estudos utilizaram ambos os estímulos (23,34,35) e ainda um estudo utilizou estímulos de sons biológicos (estalo de dedo e sucção de boca) (36) (Quadro 2). Gonzalez-Gadea et al (32) Prospectivo Transversal 24 ( Kamita (35) Prospectivo Transversal Matas et al (24) Não-verbal (tone burst). Paradigma Oddball Utilizou-se um total de 300 estímulos do tipo "tone burst" a 75 dB nHL, nas freqüências de 1000 Hz (estímulo frequente -80 a 85%) e 1500 Hz (estímulo raro -15 a 20%), apresentados de forma aleaória, com janela de análise de 512ms, filtros passa-alto de 30.00 Hz e passa-baixo de 1.00 Hz, e ganho de 15000.…”

Section: Análise Dos Estudos Selecionadosunclassified

“…Kamita (35) Verbal e não-verbal; Paradigma Oddball O PEALL com estímulo tone burst foi realizado a 75dBnNA de forma monoaural, sendo o estímulo apresentado em uma velocidade de 1,1 estímulos por segundo, totalizando 300 estímulos. O estímulo frequente foi apresentado a 1000 Hz e o raro a 2000 Hz.…”

Section: Paradigma Não Especificadounclassified

“…Dentre os 11 estudos que consideraram a análise do componente P3, foram observados cinco estudos que realizaram o registro dos PEAC na condição passiva (27,31,33,34,36) , sendo que em todos eles os participantes assistiam à um vídeo durante o procedimento; outros cinco estudos realizaram o exame na condição ativa (4,24,28,32,35) , ou seja, a criança era orientada a prestar atenção no estímulo auditivo e realizar algumas tarefas pré-determinadas, tais como contar os estímulos raros (4,24,32) pressionar um botão (28) ou ainda levantar a mão ao identificar o estímulo raro (35) . Além desses, um estudo ainda realizou a coleta dos PEAC nas duas condições (ativa e passiva) (23) .…”

Section: Paradigma Não Especificadounclassified

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Potenciais evocados auditivos corticais no transtorno do espectro do autismo: revisão sistemática

Kamita

Silva

Matas

2021

CoDAS

Self Cite

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RESUMO Objetivo Identificar e analisar quais são os achados característicos dos Potenciais Evocados Auditivos Corticais (PEAC) em crianças e/ou adolescentes com Transtorno do Espectro do Autismo (TEA) em comparação do desenvolvimento típico, por meio de uma revisão sistemática da literatura. Estratégia de pesquisa Após formulação da pergunta de pesquisa, foi realizada uma revisão da literatura em sete bases de dados (Web of Science, Pubmed, Cochrane Library, Lilacs, Scielo, Science Direct, e Google acadêmico), com os seguintes descritores: transtorno do espectro autista (autism spectrum disorder), transtorno autístico (autistic disorder), potenciais evocados auditivos (evoked potentials, auditory), potencial evocado P300 (event related potentials, P300) e criança (child). A presente revisão foi cadastrada no Próspero, sob número 118751. Critérios de seleção Foram selecionados estudos publicados na integra, sem limitação de idioma, entre 2007 e 2019. Análise dos dados: Foram analisadas as características de latência e amplitude dos componentes P1, N1, P2, N2 e P3 presentes nos PEAC. Resultados Foram localizados 193 estudos; contudo 15 estudos contemplaram os critérios de inclusão. Embora não tenha sido possível identificar um padrão de resposta para os componentes P1, N1, P2, N2 e P3, os resultados da maioria dos estudos demonstraram que indivíduos com TEA podem apresentar diminuição de amplitude e aumento de latência do componente P3. Conclusão Indivíduos com TEA podem apresentar respostas diversas para os componentes dos PEAC, sendo que a diminuição de amplitude e aumento de latência do componente P3 foram as características mais comuns.

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Auditory Brainstem Response in Children with Autism Spectrum Disorder: A Case-Control Study

Othman

Khaled

Gelaney

2022

Egyptian Journal of Ear, Nose, Throat and Allied Sciences

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Background: Autism spectrum disorder (ASD) is a group of disorders characterized by abnormal social behavior, poor communication, repetitive behaviors and atypical response to sensory information, poor auditory brainstem function in ASD could be correlated to language impairment in (ASD). Aim: The present study aimed to investigate the abnormalities in auditory brain stem response to speech stimuli among ASD children. Patients and Methods: This case-control study was carried out from January 2019 to December 2019. The study included 21 children with autism and 30 children in a normal control group, the mean age of patients and control was comparable, respectively (4.16 ± 1.09, 4.85 ± 1.42) with males predominate in both groups. We used DSM-V-TR criteria, Stanford-Binet intelligence scale V and childhood autism rating scale (CARS) for assessments. All children were assessed in the audiology unit as follows, basic audiological evaluation, tympanometry, Click evoked Auditory Brainstem Response to confirm the presence of wave V and Speech Evoked Auditory Brainstem Response (S-ABR). Data were analyzed by IBM SPSS version 20.0, using Chi-Square, Fisher's Exact Test, and the Mann-Whitney U Test. Results: ABR latency of wave V (6.36 ± 0.29) and wave A (7.41 ± 0.29 ) were detected in the patients' group, in comparison to the control group, with a significant delay (p<0.001). ABR latency of wave D in patients with mild to moderate autism was delayed in comparison to patients with severe autism with a significant difference (p= 0.03) ABR latency of wave V, A, C, and O, in patients with severe autism, was delayed in comparison to patients with mild to moderate autism with no significant difference respectively, (p=0. 85, p=0.624, P=0.94, p=0.652). ABR latency of wave E and F, in patients with mild to moderate autism, was delayed in comparison to patients with severe autism with no significant difference respectively (p=0.143, p=0.066). Conclusion: (S-ABR) is very promising in the evaluation of children with (ASD) as regards the deficit in cognitive processing, attention, auditory discrimination.

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Brainstem auditory evoked potentials in children with autism spectrum disorder

Cited by 3 publications

References 21 publications

Primitive Reflexes in Very Low Birth Weight Infants Later Diagnosed with Autism Spectrum Disorder

Primitive Reflexes in Very Low Birth Weight Infants Later Diagnosed with Autism Spectrum Disorder

Potenciais evocados auditivos corticais no transtorno do espectro do autismo: revisão sistemática

Auditory Brainstem Response in Children with Autism Spectrum Disorder: A Case-Control Study

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