Brainstem auditory-evoked responses with and without sedation in Autism and Down's syndrome

Sersen, Eugene A.; Heaney, G.; Clausen, Johs.; Belser, Richard C.; Rainbow, S.

doi:10.1016/0006-3223(90)90464-d

Cited by 30 publications

(14 citation statements)

References 16 publications

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“…In a study of 60 children with Down syndrome, Szyfter and Łącz-kowska-Przybylska [7] concluded pure tone audiometry to be unrealisable in 35 cases. Precise evaluation of the condition of the auditory organ regardless of the patient's age or mental condition became possible after objective tests, especially BAEP, were introduced into clinical practice [11,22,23].…”

Section: Discussionmentioning

confidence: 99%

Brain auditory evoked potentials in children with Down syndrome

Kręcicki¹,

Zalesska−Kręcicka²,

Kubiak³

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 99%

Brain auditory evoked potentials in children with Down syndrome

Kręcicki¹,

Zalesska−Kręcicka²,

Kubiak³

et al. 2005

International Journal of Pediatric Otorhinolaryngology

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“…Previous studies of the ABR in children with ASD primarily elicited the ABR with clicks (click-ABR) [Skoe, Krizman, Anderson, & Kraus, 2015;Spitzer, Whiteschwoch, Carr, Skoe, & Kraus, 2015]. The click-ABR, which is recorded noninvasively, reflects the activity of the subcortical auditory pathway from the distal portion of the auditory nerve to higher midbrain structures [Sersen, Heaney, Clausen, Belser, & Rainbow, 1990]. The click-ABR consists of six or seven waves that appear 10 msec after stimulation onset [Don & Kwong, 2002].…”

Section: Introductionmentioning

confidence: 99%

Atypical longitudinal development of speech‐evoked auditory brainstem response in preschool children with autism spectrum disorders

et al. 2019

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Language impairment is common in children with autism spectrum disorders (ASDs). Previous research has shown that this disability may be, in part, due to atypical auditory processing of speech stimuli. However, how speech sounds are processed in children with ASD remains largely unknown. The present study assessed the developmental pattern of auditory information processing at the level of the brainstem in preschool children with ASD using speech‐evoked auditory brainstem response (speech‐ABR). Children with ASD (N = 15) and of typical developing (TD) (N = 20), both of preschool age, were enrolled. The speech‐ABRs recorded at two different time points (T1 and T2; 9.68 months apart on average) were virtually identical in the TD group. However, in the ASD group, the wave V latency of speech‐ABR was significantly shortened and the amplitudes of wave A and C were significantly larger at T2, compared to those recorded at T1 (10.78 months apart on average). Compared to the TD group, the wave V and A latencies were prolonged at T1, whereas the wave E amplitude decreased and wave F latency prolonged at T2. There was a positive partial correlation between the language performance and the wave A amplitude in the ASD group. These results indicate that auditory processing at the subcortical level is well‐developed in the TD preschool children, but is immature and abnormal in the children with ASD at the same ages. Thus, aberrant speech processing at the brainstem level may contribute significantly to the language impairment in children with ASD at preschool ages. Autism Res 2019, 12: 1022–1031. © 2019 International Society for Autism Research, Wiley Periodicals, Inc. Lay Summary Language impairment is common in children with autism spectrum disorders (ASDs). We investigated the developmental pattern of subcortical auditory processing by monitoring changes in the speech‐evoked auditory brainstem response (speech‐ABR) over a period of 10 months in preschool children. Our results show that subcortical auditory processing is impaired and immature in children with ASD compared with age‐matched, typically developing children. The results suggest that speech‐ABR may be used as an objective measure in evaluating the language performance of children with ASD. The results also suggest that aberrant speech processing at the level of the brainstem may contribute significantly to the language impairment in preschool children with ASD.

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“…Recent publications show that wave V latency is prolonged in infants who were later diagnosed with autism spectrum disorder (ASD) [Cohen et al, ; Miron et al, ], a neurodevelopmental disorder that impairs social communication [American Psychiatric Association, ]. At older ages, some studies found prolonged wave V latency in ASD [Azouz, Kozou, Khalil, Abdou, & Sakr, ; Dabbous, ; Fujikawa‐Brooks, Isenberg, Osann, Spence, & Gage, ; Gillberg, Rosenhall, & Johansson, ; Kwon, Kim, Choe, Ko, & Park, ; Magliaro, Scheuer, Assumpção Júnior, & Matas, ; Ornitz, Mo, Olson, & Walter, ; Rosenblum et al, ; Rosenhall, Nordin, Brantberg, & Gillberg, ; Roth, Muchnik, Shabtai, Hildesheimer, & Henkin, ; Russo, Nicol, Trommer, Zecker, & Kraus, ; Sersen, Heaney, Clausen, Belser, & Rainbow, ; Skoff, Mirsky, & Turner, ; Sohmer & Student, ; Student & Sohmer, ; Tanguay, Edwards, Buchwald, Schwafel, & Allen, ; Tas et al, ; Tharpe et al, ; Ververi, Vargiami, Papadopoulou, Tryfonas, & Zafeiriou, ; Wong & Wong, ], while others found shorter wave V latency [Courchesne, Courchesne, Hicks, & Lincoln, ; Grillon, Courchesne, & Akshoomoff, ; Rumsey, Grimes, Pikus, Duara, & Ismond, ].…”

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confidence: 99%

Auditory brainstem response in infants and children with autism spectrum disorder: A meta‐analysis of wave V

2017

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Infants with autism spectrum disorder (ASD) were recently found to have prolonged auditory brainstem response (ABR); however, at older ages, findings are contradictory. We compared ABR differences between participants with ASD and controls with respect to age using a meta‐analysis. Data sources included MEDLINE, EMBASE, Web of Science, Google Scholar, HOLLIS, and ScienceDirect from their inception to June 2016. The 25 studies that were included had a total of 1349 participants (727 participants with ASD and 622 controls) and an age range of 0–40 years. Prolongation of the absolute latency of wave V in ASD had a significant negative correlation with age (R2 = 0.23; P = 0.01). The 22 studies below age 18 years showed a significantly prolonged wave V in ASD (Standard Mean Difference = 0.6 [95% CI, 0.5–0.8]; P < 0.001). The 3 studies above 18 years of age showed a significantly shorter wave V in ASD (SMD = −0.6 [95% CI, −1.0 to −0.2]; P = 0.004). Prolonged ABR was consistent in infants and children with ASD, suggesting it can serve as an ASD biomarker at infancy. As the ABR is routinely used to screen infants for hearing impairment, the opportunity for replication studies is extensive. Autism Res 2018, 11: 355–363. © 2017 The Authors Autism Research published by International Society for Autism Research and Wiley Periodicals, Inc.Lay SummaryOur analysis of previous studies showed that infants and children with autism spectrum disorder (ASD) have a slower brain response to sound, while adults have a faster brain response to sound. This suggests that slower brain response in infants may predict ASD risk. Brain response to sound is routinely tested on newborns to screen hearing impairment, which has created large data sets to afford replication of these results.

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Brainstem auditory-evoked responses with and without sedation in Autism and Down's syndrome

Cited by 30 publications

References 16 publications

Brain auditory evoked potentials in children with Down syndrome

Brain auditory evoked potentials in children with Down syndrome

Atypical longitudinal development of speech‐evoked auditory brainstem response in preschool children with autism spectrum disorders

Auditory brainstem response in infants and children with autism spectrum disorder: A meta‐analysis of wave V

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